ACC Long belongs to the group of mucolytic drugs, which are highly effective in the treatment of pathological conditions of the airways with difficult-to-separate mucus. In addition, for people suffering from chronic bronchitis and cystic fibrosis, this pharmacological agent is prescribed from a prophylactic point of view to relieve the frequency and severity of the exacerbation stage. As the instructions for use of ACC Long 600 mg indicate, there are some restrictions regarding the use of tablets. Therefore, before using, you must consult a doctor for advice, which will establish true reason diseases and develop an individualized treatment plan.

Composition and dosage form of ACC Long

ACC cough medicine is presented in a pharmacy in tablet form, easily soluble in water. The product is released in 6, 10, 20 pieces in one tube, placed in a package made of thick cardboard.

Thanks to acetylcysteine, the main substance of the drug, when it is used, a pronounced mucolytic effect is observed, due to which the thick pathological secret becomes as liquefied as possible and is easier to remove from the air channels. The principle of operation lies in the ability of the active component to block the disulfide bridges of mucopolysaccharide chains and activate the depolymerization of the mucoids of sputum formations. The drug ACC Long also shows its effectiveness in purulent formations.

In addition, acetylcysteine ​​has an antioxidant effect. The active substance also has a beneficial effect on the synthesis of glutathione, one of the main components of the antioxidant system and the process of cleansing the body with chemical means.

Due to the antioxidant activity, the degree of protection of cells from the harmful effects of free radical oxidation, which is inherent in a strong inflammatory lesion, increases.

One tablet medicinal product cough contains 600 mg of the main ingredient - acetylcysteine.

White tablets have one side with a flat surface, and the other with a dividing line in the center. To prepare the medicine for use, it is enough to dissolve 1 tablet in a container with 100 ml of warm water. A colorless liquid with a pronounced berry aroma.

Pharmacokinetics

ACC Long stands out with a high degree of absorption, is very quickly cleaved in the liver and creates pharmacologically active metabolic products - cysteine, diacetylcysteine, cystine and mixed disulfides. The indicator of the ability of this medication to be absorbed when ingested is estimated at 10%, this is due to the strong effect during the first penetration through the liver. Level max high rate in blood plasma observed after 1-3 hours. The percentage of binding to plasma proteins is 50%.

The output of unused metabolic products occurs through the kidneys. The half-life is not more than 60 minutes, in case of various disorders in the liver, this period is extended to 8 hours.

When using this medication, you should be aware of its penetration through the placental barrier. Information on the ability of the active ingredient to pass through the blood-brain barrier and be present in breast milk is not indicated.

Taking ACC Long is effective in pathological conditions of the respiratory apparatus, which occur with sputum secretions of a viscous concentration. It:

• laryngotracheitis;
• bronchitis of any form;
• tracheitis;
• bronchiectasis;
• lung abscesses;
• bronchial asthma;
• chronic obstructive pulmonary disease;
• inflammatory processes in bronchioles;
• cystic fibrosis;
• acute and chronic sinusitis;
• middle ear damage.

Admission Restrictions

Among the restrictions regarding the use of the drug ACC can be identified:

• excessive sensitivity to one of the components of the drug;
• children under 14;
• ulcerative lesions of the stomach and duodenum during exacerbation;
• discharge from the lungs and bronchi of blood in the form of veins in the mucus (hemoptysis);
• low amount of lactase in the body, its intolerance.

In addition, pregnant and lactating women are also not recommended to use a drug based on acetylcysteine ​​as a means to eliminate signs of respiratory conditions. The use of this medicine is allowed only if the expected benefit to the mother over the possible risk to the unborn baby.

How to use

The recommended dose for adult patients and children over 14 years old is 1 tablet (600 mg) once a day.

To eliminate attacks of the cough reflex in children under 14 years of age, use 1⁄2 daily norm, divided into 2-3 doses, but it is better to choose a different type of drug - powder, syrup.

Patients 6-14 years old are allowed to use the medicine in the form of a powder intended for the preparation of a suspension, 100 mg three times a day or 200 mg twice a day.

ACC Long for children 2-5 years old is allowed to give 100 mg of the drug up to three times a day in the form of granules used to prepare the drug.

In order for ACC Long to be better absorbed and act, it is recommended to use it after meals. Effervescent tablets or powder must be dissolved in a container of warm water and drunk as soon as possible. In some situations, if ascorbic acid is present in the medicinal product, the finished suspension can be kept for up to 2 hours. To enhance the mucolytic effect, you need to drink more water.

The duration of the therapeutic course is determined by the attending doctor, where the full clinical picture disease and age of the patient. Without medical advice, the medicine can be used for no more than 5 days.

Side effects

With the use of this cough medicine, adverse reactions rarely appeared. Among them are:

• headache;
• inflammatory lesions of the mucous membrane in the oral cavity;
• sensation of sound in one or both ears (tinnitus).

The following conditions have occasionally been noted:

• bouts of nausea, vomiting;
• indigestion;
• burning sensation in the chest;
• low blood pressure;
• increased heart rate;
• allergic reactions (skin rashes, itching, bronchospasm with bronchial hyperreactivity);
• bleeding as a result of excessive sensitivity to the active substance - acetylcysteine.

If the remedy was taken in a larger volume than indicated in the manual, then the person has bouts of nausea, vomiting, diarrhea, a burning sensation behind the sternum, and pain in the stomach.

In case of an overdose or the occurrence of negative manifestations, the use of the medicine should be discontinued and contact your doctor as soon as possible.

Special orders

Persons suffering from the following diseases should use the medicine with caution:

• ulcerative lesions of the stomach or duodenum during an exacerbation;
• pathological conditions, combined with streaks of blood in sputum formations;
• pulmonary bleeding;
• varicose veins veins of the esophagus;
• bronchial asthma;
• pathology of the adrenal glands;
• syndrome of violation of the liver and kidneys, to prevent the accumulation of nitrogen-containing substances in the body.

When assigning and applying the ACC, consideration should be given to:

• the use of a large amount of fluid during treatment can significantly enhance the mucolytic effect of acetylcysteine;
• 1 tablet of this drug - 0.01 XE, which is important to know for people with diabetes;
• ACC tablets contain sodium compounds, which should be taken into account by people on a salt-free diet;
• given the influence of the active component on the process of splitting histamine, patients with intolerance to this substance are recommended to stop using ACC Long at the first suspicion of a reaction;
• persons who have obstructive bronchitis and bronchial asthma require strict systematic control of bronchial patency;
• the tablets contain lactose, which indicates a ban this medicine persons with rare hereditary forms of galactose intolerance;
• it is not recommended to use acetylcysteine ​​simultaneously with antitussives, which can lead to suppression of the cough reflex caused by such drugs;
• acetylcysteine ​​and nitroglycerin are perfectly combined, there is an enhanced vasodilating effect in the latter;
• combine acetylcysteine ​​with antibacterial agents not desirable, as the degree of bioavailability of antibiotics is reduced.

Take antibiotics for complex treatment allowed 2 hours after the use of ACC Long.

Analogues

Among medications containing acetylcysteine, emit:

• Acetylcysteine ​​Hemofarm;
• Acetylcysteine ​​Stada;
• Fluimucil;
• Exomyuk;
• Tussik;
• Mucosolvin;
• Mukomist.

The price of tablets for 10 pieces is 362 rubles, for 20 pieces. - 553 rubles.

ACC is an effective antitussive that helps with colds, bronchitis, accumulation of viscous sputum, asthma, sinusitis. But the use of this remedy should be agreed with the doctor.

Which is used to thin sputum in diseases of the respiratory system with the formation of mucus. It has antioxidant and pneumoprotective properties, increases the synthesis of glutathione. The active substance is acetylcysteine. After ingestion, it is rapidly absorbed and metabolized in the liver to cysteine. The drug contains such excipients as ascorbic and citric acids, manitol citrate, lactorase, saccharin, flavors. Available in the form of effervescent tablets.

"ACC Long" is prescribed for the treatment of pathologies of the bronchopulmonary system, both acute and chronic, in diseases that are characterized by high education sputum and gradual worsening of expectoration. The drug is used for acute, chronic and obstructive bronchitis, bronchial asthma, cystic fibrosis, laryngitis, tracheitis, sinusitis. It is possible to prescribe a medicine for inflammation of the middle ear.

Usually, tablets for adults and children over 14 years of age should be taken at a dose of 500 to 600 milligrams per day, ACC Long for children from six to 14 is prescribed in the amount of 300 milligrams. For patients suffering from cystic fibrosis, it is possible to increase the dose of the drug to 800 milligrams. The medicine must be dissolved in water, juice, or cold tea and drunk immediately. It is recommended to take the drug after meals. Additional fluid intake has a positive effect and only enhances the mucolytic effect of ACC Long.

For uncomplicated diseases, tablets are used for seven days. In case of long-term illnesses, the duration of treatment is determined separately and only by a qualified specialist. Treatment chronic diseases may take long time or take courses up to 6 months. If you mistakenly take a smaller amount of a medicine or forget to take it at all, continue taking it as directed by your doctor.

From treatment with the drug may occur side effects. In some cases, it can be heartburn, diarrhea, headache, vomiting, nausea, tinnitus, inflammation of the oral mucosa. Extremely rare cases reported allergic reactions, rashes, bronchospasm, tachycardia, itching. If you notice any side effects, you should immediately stop taking the medicine. It is not recommended to take tablets if hypersensitivity to the components of the drug is recorded.

Simultaneously with "ACC Long" can not be used with simultaneous treatment with other cough suppressants, dangerous mucus stagnation may occur. Deliberate or erroneous overdose may cause vomiting, heartburn, diarrhea and nausea. Even with an extreme overdose of severe or life-threatening side effects not visible.

During pregnancy and lactation, you can take the medicine only on the advice of a doctor. For the treatment of newborns and young children under six years of age, tablets are not prescribed due to the rather high content of acetylcysteine.

The drug is released without a prescription in the original package of 10 tablets. The shelf life of the drug is 3 years. After the date marked on the package, it is strictly forbidden to take the pills. Store the drug in a dry place, out of the reach of children, at room temperature.

Quite a popular drug is ACC Long. Reviews about him are mostly positive. The medicine effectively fights and thins sputum. In rare cases, minor side effects may occur. Because it shouldn't be abused. It is mandatory to consult a specialist before use.

Indications for use

ACC LONG is a drug designed to thin viscous sputum and facilitate its removal from the respiratory tract.
ACC LONG applied with all diseases of the respiratory system, which are accompanied by the formation of a thick and difficult to separate secret, for example: acute bronchitis and exacerbation of chronic bronchitis, laryngitis, sinusitis, tracheitis, influenza, bronchial asthma and, as an additional therapy, cystic fibrosis.

How to take Azz Long

In the absence of other prescriptions, it is recommended to adhere to the following doses of ACC LONG.
Adults and children over 12 years of age: one effervescent tablet once a day.
The maximum duration of admission is 3-6 months with long-term treatment.
If your symptoms worsen or do not improve after 2 weeks of treatment, you should consult your doctor.
cystic fibrosis: as mentioned above. It is possible to use in children from 6 years old - one effervescent tablet once a day.
Mode of application
Dissolve the effervescent tablet in one glass of cold or warm water. The finished solution should not be mixed with other drugs. The drug can be taken regardless of food intake.

If you have overdosed on ACC LONG
So far, no severe side effects and signs of drug intoxication have been observed, even with a significant overdose.
If the dose is exceeded, irritation may occur. gastrointestinal tract(eg, nausea, vomiting, diarrhea). Children are at risk of bronchial hypersecretion (excessive sputum production). In case of a suspected overdose of ACC LONG, you should contact your doctor.
If you forget to take ACC LONG
If you miss one dose of ACC LONG or take too little dose, wait until the next dose and continue taking the drug as directed in the dosage recommendations. Do not double your dose to make up for a missed dose.
If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

Contraindications

Do not take ACC LONG if you are hypersensitive (allergic) to acetylcysteine ​​or any of the other ingredients of ACC LONG, or if you have an exacerbation of gastric ulcer or duodenum, galactose intolerance, lactase deficiency and malabsorption of glucose-galactose.
ACC LONG should not be used to treat children under 12 years of age (6 years for cystic fibrosis).

Special Warnings and Precautions for Use

When taking ACC LONG, it is not recommended to use antitussive drugs.
Due to the risk of bronchospasm in patients with bronchial asthma and bronchial hyperreactivity, caution is advised. If a hypersensitivity reaction or bronchospasm occurs, the use of the drug should be immediately discontinued and appropriate measures taken. When taking the drug, you should be careful if you suffer from bronchial asthma, if you have a history of or currently have a stomach or intestinal ulcer, as well as the risk of gastrointestinal bleeding(for example, latent peptic ulcer or esophageal varices), since taking acetylcysteine ​​​​may cause vomiting.
Taking acetylcysteine, especially at the beginning of treatment, can lead to liquefaction of bronchial secretions (sputum). In case of violation of the ability to independently cough up (suffocate enough), appropriate measures should be taken to prevent dangerous stagnation of sputum - bronchial drainage and aspiration.
Acetylcysteine ​​leads to inhibition of diamine oxidase (DAO) in vitro by 20-50%. Caution should be exercised in patients with histamine intolerance. Long-term therapy should be avoided in such patients, as ACC LONG interferes with histamine metabolism and may cause symptoms of intolerance (eg, headache, runny nose, itching).
During the use of acetylcysteine, in very rare cases, the occurrence of severe skin reactions, such as Stevens-Johnson syndrome and Lyell's syndrome, has been observed. In the event of changes in the skin and mucous membranes, you should immediately stop taking the drug and seek medical help.
The presence of a slight sulfuric odor, which may appear when the package is opened, is characteristic of the active substance. The smell quickly evaporates and does not affect the effectiveness of the drug.
The drug is not recommended for use during pregnancy and during breastfeeding.
One effervescent tablet contains approximately 6.03 mmol (138.8 mg) sodium. This should be taken into account when using the drug in patients on a controlled sodium diet (low sodium / low salt content).
Due to the presence of lactose in the composition of the drug, ACC LONG is contraindicated in patients with rare hereditary galactose intolerance, lactase deficiency or malabsorption of glucose-galactose.

Due to the presence of ascorbic acid in the composition of the drug use with caution in: deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, nephrolithiasis.
Ascorbic acid increases the risk of developing crystalluria in the treatment of short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Ascorbic acid can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH). High doses of ascorbic acid can give false-negative test results for blood hidden in the feces.

Taking other drugs

Tell your doctor or pharmacist if you are taking/using or have recently taken/have used any other medical preparations including over-the-counter drugs.
The addition of other drugs to acetylcysteine ​​preparations should be avoided. Simultaneous administration of acetylcysteine ​​and activated charcoal during intoxication therapy may reduce the effectiveness of acetylcysteine.
The reports received so far about the ability of acetylcysteine ​​or other mucolytics to inactivate antibiotics are exclusively experimental. in vitro in which the respective substances are mixed directly with each other. However, for safety reasons, oral antibiotics should be taken separately from acetylcysteine, with at least a 2-hour interval.
Simultaneous administration of acetylcysteine ​​and nitroglycerin can lead to an increase in the vasodilating and antiplatelet action of the latter.
The simultaneous use of acetylcysteine ​​and carbamazepine can lead to a decrease in carbamazepine concentrations to subtherapeutic levels. Acetylcysteine ​​is incompatible with most metal preparations and is inactivated by oxidizing agents.
Ascorbic acid-related interactions
Ascorbic acid with simultaneous use reduces the chronotropic effect of isoprenaline. With prolonged use, it can disrupt the interaction of disulfiram-ethanol. Increases the toxicity of amygdalin when taken together. Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants. Increases the concentration of benzylpenicillin and tetracyclines in the blood.
Improves intestinal absorption of iron preparations; may increase iron excretion when used concomitantly with deferoxamine, as a result of which ascorbic acid should not be taken during the first month of treatment with deferoxamine. Simultaneous intake of ascorbic acid and aluminum hydroxide may increase the absorption of aluminum.

Pregnancy and breastfeeding

Pregnancy
To date, there is not enough data on the use of acetylcysteine ​​in pregnant women. Therefore, taking ACC LONG is not recommended during pregnancy and during breastfeeding.
Breast-feeding
Data on the ability of acetylcysteine ​​to penetrate into breast milk is not available. Therefore, taking ACC LONG is not recommended during pregnancy and during breastfeeding.

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Influence on the ability to drive vehicles or work with mechanisms

Special studies the effect of the drug on the ability to drive vehicles and other mechanisms has not been conducted.

Important information about some components

One effervescent tablet contains 6.03 mmol (138.8 mg) sodium. This should be taken into account when using the drug in patients on a controlled sodium diet.
One effervescent tablet of ACC LONG contains 75 mg of ascorbic acid, which corresponds to the recommended daily intake of vitamin C.

Possible side effects

Like all medicines, ACC LONG can cause side effects, although not everyone gets them.
During treatment with ACC LONG, hypersensitivity reactions, angioedema, urticaria, itching, and rash may occur. In the event of the first signs of hypersensitivity, you should immediately stop taking the drug and seek medical help.
The following adverse reactions have been registered:
Uncommon (may affect up to 1 in 100 people): stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, fever, tachycardia, hypotension, headache, tinnitus.
Rare (may affect up to 1 in 1,000 people): dyspepsia, shortness of breath, bronchospasm.
Very rare (may affect up to 1 in 10,000 people): anaphylactic shock, anaphylactic / anaphylactoid reactions, hemorrhage.
Frequency unknown (based on the available data, the frequency of occurrence cannot be determined): swelling of the face.
Hypersensitivity reactions of the skin and respiratory system may develop in predisposed patients, bronchospasm may occur in patients with bronchial hyperreactivity and bronchial asthma (see "Special warnings and precautions for use"). Very rarely, cases of severe skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been reported in association with the use of acetylcysteine.
The decrease in blood platelet aggregation in the presence of acetylcysteine ​​has been confirmed by various studies. The clinical significance of this phenomenon has not yet been established.
Exhaled air can acquire bad smell, probably as a result of the release of hydrogen sulfide.
Reporting adverse reactions
If you experience any adverse reactions, it is recommended that you consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the instructions for use of the drug. By reporting adverse reactions, you help to get more information about the safety of the drug.

Instruction
by application medicinal product for medical use

Registration number:

P N008857-240914

Trade name of the drug:

ACC ® Long.

International non-proprietary name:

acetylcysteine.

Dosage form:

effervescent tablets.

Compound:

1 effervescent tablet contains: active substance: acetylcysteine ​​- 600.00 mg; Excipients: citric acid - 625.00 mg; sodium bicarbonate - 327.00 mg; sodium carbonate - 104.00 mg; mannitol -72.80 mg; lactose - 70.00 mg; ascorbic acid - 75.00 mg; sodium cyclamate - 30.75 mg; sodium saccharinate dihydrate - 5.00 mg; sodium citrate dihydrate - 0.45 mg; blackberry flavor "B" - 40.00 mg.

Description: round flat-cylindrical tablets of white color, with a chamfer and a risk on one side, with a blackberry odor. There may be a slight sulfur odor.
Reconstituted Solution: colorless transparent solution with a blackberry odor, a slight sulfuric odor is possible.

Pharmacotherapeutic group:

mucolytic agent.

ATX code: R05CB01.

Pharmacological properties

Pharmacodynamics
Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.
It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and thus neutralize them. In addition, acetylcysteine ​​promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics
Absorption is high. They are rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced "first pass" effect through the liver). The time to reach the maximum concentration in the blood plasma is 1-3 hours. Communication with blood plasma proteins is 50%. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (T1 / 2) is about 1 hour, liver dysfunction leads to an extension of T1 / 2 up to 8 hours. Penetrates through the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the blood-brain barrier and be excreted in breast milk.

Indications for use

Respiratory diseases, accompanied by the formation of viscous sputum difficult to separate:
acute and chronic bronchitis, obstructive bronchitis;
tracheitis, laryngotracheitis;
pneumonia;
lung abscess;
bronchiectasis, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis;
cystic fibrosis;
Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Contraindications

Hypersensitivity to acetylcysteine ​​or other components of the drug;
peptic ulcer stomach and duodenum in the acute stage;
hemoptysis, pulmonary bleeding;
pregnancy;
lactation period;
childhood up to 14 years (for this dosage form);
lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Carefully: peptic ulcer of the stomach and duodenum in history, bronchial asthma, obstructive bronchitis, hepatic and / or kidney failure, histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, diseases of the adrenal glands, arterial hypertension.

Use during pregnancy and during breastfeeding

Data on the use of acetylcysteine ​​during pregnancy and breastfeeding are limited, so the use of the drug during pregnancy is contraindicated.
If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Methods of application and doses

Inside, after eating.
Effervescent tablets should be dissolved in one glass of water. Tablets should be taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. With short-term colds, the duration of admission is 5-7 days. In chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a preventive effect.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy:
Adults and children over 14 years of age: 1 effervescent tablet 1 time per day (600 mg).

Side effect

According to the World Health Organization (WHO), adverse effects are classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
allergic reactions
infrequently: skin itching, rash, exanthema, urticaria; angioedema, lowering blood pressure, tachycardia;
very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the respiratory system
rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
From the sense organs
infrequently: noise in ears.
From the gastrointestinal tract
infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, dyspepsia.
Other
very rarely: headache, fever, isolated reports of bleeding due to hypersensitivity reactions, decreased platelet aggregation.

Overdose

Symptoms: with an erroneous or deliberate overdose, such phenomena as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.
Treatment: symptomatic.

Interaction with other drugs

With the simultaneous use of acetylcysteine ​​​​and antitussives due to the suppression of the cough reflex, sputum stagnation may occur.
When used simultaneously with antibiotics for oral use (penicillins, tetracyclines, cephalosporins, etc.), their interaction with the thiol group of acetylcysteine ​​is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except cefixime and loracarbef).
Simultaneous use with vasodilators and nitroglycerin may lead to an increase in vasodilator action.

special instructions

Note for patents with diabetes:
1 effervescent tablet corresponds to 0.001 XE.
When working with the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.
When using acetylcysteine, cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been reported very rarely. If there are changes in the skin and mucous membranes, you should immediately consult a doctor, the drug should be stopped.
In patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be administered with caution under the systemic control of bronchial patency.
Do not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Influence on the ability to drive vehicles, mechanisms

There are no data on the negative effect of the drug ACC ® Long in recommended doses on the ability to drive vehicles, mechanisms.

Special precautions for the disposal of unused medicinal product

There is no need for special precautions when discarding unused ACC ® Long.
Close the tube tightly after taking the pill!

Release form

Effervescent tablets 600 mg
Primary packaging
6, 10 or 20 effervescent tablets in a polypropylene tube.
secondary packaging
1 tube in a cardboard box along with instructions for use.

Storage conditions

In a dry, dark place at a temperature not exceeding 30 °C.
Keep out of the reach of children.

Best before date

3 years.
Do not use after the expiration date.

Holiday conditions

Without recipe.

Manufacturer

RU holder: Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia;
Produced: Hermes Artsnaimittel GmbH, Germany.

Send consumer claims to ZAO Sandoz:
125315, Moscow, Leningradsky prospect, 72, bldg. 3

Cough is an unconditioned reflex. It helps to clear the respiratory tract from phlegm, mucus, bacteria, viruses and foreign bodies. A wet cough can be a real problem if the secret is thick and hard to cough up.

In order to alleviate the condition and make the cough easier, various expectorant drugs are recommended, among them ACC Long.

In contact with

Classmates

The tool is produced by a large pharmaceutical company that has long established itself in the market. High efficiency, ease of use and availability in the pharmacy network makes ACC Long effervescent tablets the drug of choice for cough relief. Full details are in the abstract.

Composition of ACC Long 600 mg

The effectiveness of a pharmaceutical product is due to the active substances that make up the composition. To obtain the required physico-chemical characteristics, additional ingredients are included in the formulation. Instructions for use ACC Long thoroughly describes the composition.

Table 1. Components of ACC Long effervescent tablets

Name	Dosage (mg)	Action
Active ingredient
Acetylcysteine	600	Promotes liquefaction of the tracheobronchial secretion, accelerates its synthesis and removal from the lungs, promotes recovery
Additional components
Lemon acid	625	Accelerates cellular metabolism and improves cellular respiration, provides dissolution due to reaction with soda and water
sodium bicarbonate	327	Reduces the viscosity of the tracheobronchial secretion, has an expectorant effect
Soda	104	Provides dissolution of effervescent tablets in water, extends the duration of the drug
Mannitol	73	Diuretic, has a diuretic effect
Vitamin C	75	Antioxidant, takes part in metabolism, normalizes redox processes
Sodium cyclamate	31	Sweetener
Milk sugar	70	Filler
Saccharin	5	Sweetener
Sodium salt of citric acid	0.5	preservative
Berry flavor	40	Gives a berry flavor

Mechanism of action

ACC Long effervescent tablets, instructions for use of which are in each package of the product, begin to act almost immediately due to the active substance - acetylsteine.

The maximum concentration in the patient's blood is observed 60-180 minutes after taking the effervescent tablet.

Table 2. The mechanism of action of effervescent cough tablets ACC Long

Direction	Produced effect
Sputum	Destroys compounds of polysaccharides of tracheobronchial secret due to the presence of highly active organic compounds. Increases the rate of formation of mucin polymers. Helps thin mucus
Mucosal cells	Stimulates activity, stimulates the destruction of fibrin (protein)
Free radicals and oxygen metabolites	Reduces activity, helping to reduce the inflammatory process in the airways
Glutathione	Stimulates production, which helps accelerate the destruction of toxic substances in the body

Instruction ACC Long warns that acetylcysteine ​​is able to cross the placenta into the amniotic fluid. The elimination half-life of the drug is approximately 60 minutes. In case of violations in the liver, the interval is prolonged by 6–8 times. Almost completely excreted by the urinary system.

Indications

Effervescent tablets ACC 600 mg instructions for use are recommended for the treatment of diseases, the course of which is complicated by the release of thick tracheobronchial secretions. These include:

• , rhinitis, ;
• purulent inflammation of the lung;
• diseases of the respiratory system affecting the bronchi, in acute or chronic form, including obstructive ones;
• cystic fibrosis;
• inflammatory diseases of the respiratory canals, etc.

Inflammation of the lungs is also known as pneumonia. It is an inflammation of the lung tissue of various etiologies. The main cause of the development of the disease, as a rule, is an infection. Pneumonia can occupy both a small lobe and the entire lung. It is characterized by fever, cough, weakness, pain in the lungs. In the absence of timely competent treatment, it can cause death.

Instructions for use ACC 600 recommends taking effervescent tablets for otitis, rhinitis, tracheitis, pharyngitis, laryngitis. These diseases are expressed in inflammation of the mucous membranes of the ear, nose, trachea, pharynx, larynx, respectively. They develop as a result of a viral infection or under the influence of other pathogenic factors.

The list of indications for use, according to the instructions, includes a lung abscess. This is a destructive process that leads to the appearance of purulent formations in the lungs. Most often, an abscess causes infection with Staphylococcus aureus. The patient is excreted with an admixture of pus, there is a fever, general weakness, etc. An extremely dangerous disease that requires immediate intervention.

Bronchitis is one of the most common reasons for visiting a doctor. Distinguish diseases. Various factors lead to their occurrence, their manifestations also differ from each other.

Effervescent tablets ACC 600 mg instructions for use (600 - the highest dosage) recommends regardless of the type. The remedy is effective in the obstructive form, which is characterized not only by inflammation, but also by damage to the bronchial mucosa.

A hereditary disease that leads to pathologies of the endocrine glands is called cystic fibrosis (cystic fibrosis). The disease is widespread and leads to severe respiratory disorders. Cough is detected almost immediately after birth. Gradually, it becomes more intense and is accompanied by the release of thick sputum.

The appearance of wheezing, whistling, shortness of breath, chest tightness - these are some of the symptoms of bronchial asthma. This disease occurs due to allergic or immunological reactions. Leads to a chronic inflammatory process in the bronchi. Asthma therapy is aimed at the cause itself and at the relief of symptoms. ACC Long effervescent tablets are suitable for thinning sputum and stimulating its release.

You can read more about other indications for use in the instructions and ask your doctor. All of these pathologies must be treated strictly according to the recommendations of a specialist.

Instructions for use of the effervescent tablet

Annotation contains detailed information. She describes how to take ACC Long, in what quantity and for what pathologies. The tool, according to the instructions for use, has its own characteristics and contraindications.

How to take adults?

Effervescent tablets should be taken dissolved immediately after eating. It is important to consume the resulting mixture quickly, in extreme cases, no more than after 2 hours. Instruction ACC Long 600 recommends taking the remedy for a week.

In some pathologies, it is permissible to increase the period (cystic fibrosis, inflammatory diseases of the respiratory canals, etc.). May be used to prevent exacerbations in chronic diseases.

How many times a day to drink?

One of the key benefits of the drug is ease of consumption. Effervescent tablets ACC Long 600 mg instructions for use recommend taking a day once, no later than 18 hours. Before going to bed, the remedy should not be drunk.

What water to dissolve?

There are some peculiarities of accepting funds. should be added to warm boiled water. Do not mix with tea, coffee, juice. When dissolving, it is better to use a glass container. Contact with metal, rubber and oxidizing agents should be avoided.

Important information for patients

The agent is recommended to be consumed together with a large amount of liquid to enhance the mucolytic effect. Assign, according to the instructions for use, ACC Long effervescent tablets to adults and adolescents from the age of 14. When carrying and breastfeeding, a remedy can be prescribed only if the expected benefit outweighs the risk to the fetus. Contraindications include:

• individual sensitivity to the components of the drug, including lactose;
• bleeding in the lungs or blood in the sputum;
• acute peptic ulcer;
• diabetes.

What reviews does the drug receive?

Patients who used the tablets for treatment were mostly satisfied with the effect produced. The obvious benefits of ACC Long 600 mg include:

• high efficiency;
• convenient dosage form;
• fast action;
• low likelihood of side effects;
• availability in the pharmacy network;
• nice blackberry flavor.

Many consider it an advantage how many times a day to take ACC Long in case of illness. A single dose is one of the obvious advantages.

There are also a number of disadvantages:

• the remedy does not help with dry cough, and the instructions for use do not contain such information;
• the drug is quite expensive;
• there are contraindications and restrictions:
• not recommended in combination with certain drugs (a number of antibiotics).

Analogues

On the pharmacy shelves there are many products with a similar composition. Alternatively, other acetylstein-based products can be used:

• Mukobene;
• ESPA-NAC;
• Mukomist;
• Acestine;
• etc.

The analogue of ACC Long must be discussed with a specialist. Dosages and method of application may vary significantly.

The tool is produced by the same company and has the same indications for use. When answering the question of which is better, or ACC Long, you should pay attention to their main difference - the dosage. ACC 100 mg contains similar components, but in smaller quantities. According to the instructions for use, the remedy can be prescribed to children from 2 years of age. However, for adults, a single dose is not expected.

Tablets with a lower dosage of the active substance. Recommended from 2 years old. They have similar recommendations and restrictions. For adults, it is supposed to be taken 1-3 times a day.

Conclusion

1. ACC Long 600 mg is an excellent remedy for the treatment of wet cough.
2. It effectively thins mucus and stimulates its removal from the lungs.
3. It is quite convenient to take ACC: it is enough to dissolve the agent in warm water. The pleasant blackberry taste makes therapy simple and pleasant.
4. Despite all the advantages of ACC Long, you should carefully study the instructions for use before use.

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