Name: Flemoxin Solutab

Name: Flemoxin Solutab (Flemoxin Solutab)

Indications for use:
Infections caused by bacteria sensitive to amoxicillin (diseases of the genitourinary system, respiratory organs, gastrointestinal tract, soft tissue and skin infections).

Pharmachologic effect:
Broad-spectrum antibacterial agent. The active substance of Flemoxin Solutab is amoxicillin trihydrate (semi-synthetic penicillin, a beta-lactam antibacterial agent). Has bactericidal action. Effective against gram-negative and gram-positive bacteria such as: S. pneumoniae, Streptococcus pyogenes, Clostridium tetani, Neisseria gonorrhoeae, C. welchii, N. meningitidis, Moraxella catarralis, Staphylococcus aureus, Bacillus anthracis, Staphylococcus spp, Listeria monocytogenes, Haemophilus influenzae, Helicobacter pylori. Less effective against pathogens of intestinal infections: Escherichia coli, Shigella sonnei, Enterococcus faecalis, Salmonella typhi, Proteus mirabilis, Vibrio cholere. It is inactive against microorganisms that produce beta-lactamase, as well as against indole-positive Proteus, Pseudomonas, Enterobacter.

The peculiarity of the dosage form (Solutab) after oral administration ensures rapid absorption in the gastrointestinal tract and complete (over 93%) absorption. Reception during meals is not accompanied by changes in the absorption of the active substance of the product. The maximum concentration of amoxicillin in the blood plasma is detected after 60-120 minutes. after acceptance. When taking Flemoxin Solutab, there is a higher highest concentration amoxicillin in blood plasma than when taking an insoluble dosage form of this antibiotic. Acid-resistant active ingredient.

After internal administration of amoxicillin at a dose of 375 mg, Cmax in blood plasma is observed after 120 minutes (6 μg / l). The maximum concentration of amoxicillin in the product Flemoxin Solutab increases by 2 times if the dose taken is 2 times higher than 375 mg. Amoxicillin binds to plasma proteins in an amount of 20% of the administered dose. The accumulation of the antibiotic when prescribing therapeutic doses of the product occurs in bone tissue, mucous membranes, intraocular fluid, and sputum. In bile, there is an increase in the concentration of amoxicillin compared to its level in the blood by 2-4 times. Approximately 25-30% of amoxicillin (compared to the content in the blood) is determined in the umbilical vessels and within the fetal waters. Despite the insufficiently good passage of amoxicillin through the blood-brain barrier, 20% of amoxicillin from its concentration in blood plasma is determined in the cerebrospinal fluid during meningitis.

In the body, it is partially metabolized to inactive metabolites. Excreted by the kidneys: 20% - by glomerular filtration and 80% - by tubular excretion. After 8 hours after taking the product, 90% of the active substance is excreted in the urine (and unchanged - 60-70%).

AT childhood(up to 6 months, in premature babies) the half-life of amoxicillin is 3-4 hours. In the case of normal functioning of the kidneys, the half-life of the active substance is 1-1.5 hours. With impaired renal function (creatinine clearance - 15 ml / min or less), the half-life increases and can reach up to 8.5 hours with anuria. In violation of liver function, the half-life does not change.

Flemoxin Solutab method of administration and dosage:
Flemoxin Solutab has a pleasant tangerine-lemon taste. Tablets are swallowed without chewing, taken before or after a meal. You can divide the tablet into several parts and chew with water. It is also allowed to dissolve the tablet in water (in 20 ml - to obtain a syrup, in 100 ml - to obtain a suspension).

Flemoxin Solutab is prescribed for infections of bacterial origin of mild to moderate severity at a dose of 0.5-2 g per day, the daily dose is divided into 2 doses (for adults). In pediatrics, it is prescribed for children from 1 year old: from 1 year to 3 years old - 0.125 g 3 r / s or 0.25 g 2 r / s; from 3 to 6 years - 0.25 g 3 r / s or 1.375 g 2 r / s. The course of treatment is 5-7 days. For streptococcal infections, it is recommended to take the product for 10 days. Approximately for children, the product is prescribed at the rate of 30-60 mg / kg of body weight per day, divided into 2-3 doses. The dosage is prescribed by the doctor individually, depending on the age, general condition, severity of the disease and the sensitivity of microorganisms to amoxicillin.

In case of severe infections or recurrent chronic diseases, the dose is 0.75-1 g 3 times a day. In pediatrics - 60 mg / kg of body weight (divided into 3 doses.)

For the eradication of Helicobacter pylori infection: 2 g / s (divided into 2 doses).
In uncomplicated acute gonorrheal infection - 3 g per 1 dose in combination with probenicide (1 g).

In case of impaired renal function with creatinine clearance less than 10 ml / min, the dosage is reduced by 15-50%.
Reception of Flemoxin Solutab should continue after the disappearance of signs of the disease for another 2 days.

Flemoxin Solutab contraindications:
Allergic reaction to antibacterial products of the penicillin and cephalosporin series, as well as to additional substances Flemoxin Solutab.

Flemoxin Solutab side effects:
Rare side effects: itching in the anus, diarrhea, interstitial nephritis; thrombocytopenia, hemolytic anemia, agranulocytosis, skin allergic reactions in the form of a small papular rash.
Very rare: hemorrhagic and pseudomembranous colitis, Steven Johnson syndrome, erythema multiforme, angioedema, anaphylactic shock.

Pregnancy:
Flemoxin Solutab is not contraindicated in pregnant and lactating mothers.

Overdose:
An overdose of Flemoxin Solutab may have the following symptoms: vomiting, nausea, diarrhea. Due to vomiting and diarrhea, dehydration of the body and an imbalance in water and electrolyte balance can occur. In case of an overdose, enterosorbents, laxatives of the salt group, hydration measures are prescribed.

Use with other medicinal products:
There is inhibition of tubular excretion of amoxicillin when combined with phenylbutazone, probenecid, oxyphenbutazone, to a lesser extent - acetylsalicylic acid and sulfinpyrazone. This can lead to an increase in the concentration of amoxicillin in the blood plasma and an increase in its half-life.

A decrease in the effectiveness of hormonal contraceptives was found when combined with amoxicillin.
Unlike ampicillin, the combination of amoxicillin with allopurinol does not increase the incidence of skin reactions.
Neutralize the bactericidal action of amoxicillin bacteriostatic antibacterial agents(macrolides, tetracyclines, chloramphenicol).

Release form:
Tablets 125; 250; 500; 1000 mg. Tablets of white or white-yellow color, oblong shape. Engravings: for 125 mg tablets - "231"; 250 mg - "232"; 500 mg - "234"; 1000 mg - "236". On one side of the tablet - the logo of the manufacturer, on the other - the risk. In a contour shell - 20 tablets.

Storage conditions:
Do not use after the date indicated on the package. Store at room temperature.

Flemoxin Solutab composition:
Active substance: amoxicillin trihydrate.
Additional ingredients: microcrystalline cellulose, dispersed cellulose, vanillin, crospovidone, saccharin, tangerine flavor, lemon flavor, magnesium stearate.

Additionally:
It has been shown that when prescribing penicillin products to patients with lymphocytic leukemia or infectious mononucleosis, the appearance of a skin rash often develops -
exanthema (60-100%), which is not due to hypersusceptibility to the product. A similar effect in the anamnesis of life is not a contraindication to the appointment of penicillins, incl. and amoxicillin.

Reactions of allergic genesis when taking ampicillin are more common than when using penicillins, but less often than when taking ampicillin.
There is cross-resistance between cephalosporin and penicillin antibiotics.
There is a risk of superinfection, as in the case of the appointment of penicillins.
At the first sign of pseudomembranous colitis (severe diarrhea), appropriate treatment is necessary.

Attention!
Before using the medication "Flemoxin Solutab" you need to consult a doctor.
The instructions are provided solely for familiarization with " Flemoxin Solutab».

Content

The drug Flemoxin Solutab is an antibacterial and bactericidal drug, the active component of which is amoxicillin. Flemoxin Solutab is a broad spectrum antibiotic. The tool is produced by the Dutch company Astellas Pharma. Read the instructions for use of the medicine.

Composition and form of release

Flemoxin Solutab is available only in tablet format, there are no other types of funds. The composition of the drug:

Pharmacodynamics and pharmacokinetics

The drug is an antibiotic from the group of semi-synthetic penicillins. The active substance is a hydroxyl analogue of ampicillin, which has a bactericidal effect (lysis - cell destruction) against Pneumonia faecali, Staphylococcus pyogene, Streptococcus, Escherichia coli, Shigella, salmonellosis pathogens, Haemophilus influenzae Klebsiella, gonococci, meningococci, mycoplasmas. Enterobacteria that produce penicillinase are resistant to it.

Amoxicillin paired with metronidazole kills Helicobacter pylorus, can inhibit its resistance to metronidazole. The substance is cross-resistant to ampicillin. If you combine the component with clavulanic acid, then it will begin to show activity against bacteroids, legionella, pseudomonads. After oral administration, the tablets are rapidly absorbed and are not destroyed by the hydrochloric acid of the stomach. The component reaches its maximum concentration after 1-2 hours, the rate of absorption does not depend on food intake.

After metabolism by transpeptidase, amoxicillin binds to plasma proteins by 20%, is found in the liver, the half-life is 1-1.5 hours. 60% of the dose of the drug is excreted in the urine, a small amount - in the feces. In neonates and elderly patients, the excretion time is increased. The active component penetrates the brain under the condition of inflammation of the soft meninges removed by hemodialysis.

Indications for the use of Flemoxin

The instructions for use of Flemoxin Solutab say about its indications. These include:

• bronchitis, pneumonia, tonsillitis, paratonsillitis, pharyngitis;
• infections of the gastrointestinal tract, gynecological diseases, skin, soft tissues;
• gonorrhea, listeriosis, leptospirosis;
• peritonitis, cholecystitis, cervicitis, cystitis, endometritis;
• pyelitis;
• pyelonephritis, urethritis;
• exacerbation of chronic gastritis, peptic ulcer duodenum or stomach.

Method of application and dosage

Instructions for use of Flemoxin Solutab differ depending on the type of disease, the age of the patient, the severity of the infectious process, and the presence of foci. The rule of taking pills remains similar - orally, inside, with water, regardless of food. For young children, a suspension-dispersion can be prepared from a tablet.

Flemoxin Solutab for adults

For use by adults, 250-500 mg tablets per day are indicated for mild illness, up to 1 g per day for severe. The interval is 8 hours. For the relief of symptoms of acute uncomplicated gonorrhea, the instruction advises taking 3 g of the drug once in combination with Probenecid. For parenteral administration, adults intramuscularly appoint 1 g twice a day, intravenously - 2-12 g of xenobiotic per day.

Flemoxin for children

For oral administration, children under 2 years of age are prescribed 20 mg / kg body weight of tablets, 2-5 years - 125 mg once, 5-10 years - 250 mg, over 10 - 250-500 mg. Intramuscularly, 50 mg / kg of body weight per day is prescribed, a single dose of 500 g can be administered twice a day, intravenously - 100-200 mg / kg of body weight per day. Children's Flemoxin are tablets of 125 and 250 mg. They are used in pediatrics for the treatment bacterial infections respiratory system: sinusitis, otitis, tonsillitis, bronchopnemonia, bronchitis, tonsillitis.

It is better for young children to give a suspension, an older child can take the whole tablet or chew it. Due to flavorings, it does not have an unpleasant taste. The daily dosage for children is 30-60 mg / kg of body weight in 2-3 doses, with a complex course of the disease - 60 mg / kg of body weight in three doses. Treatment of mild and moderate infections lasts 5-7 days, streptococcal infection - 10 days. After relief of severe symptoms, therapy continues for another 2 days.

In the treatment of angina

The defeat of the tonsils is a sore throat. It is caused by hemolytic streptococci or staphylococci, against which Flemoxin Solutab is effective. It is important to treat the disease in time, otherwise it can be complicated by paratonsillar abscess, nephritis, tonsillogenic sepsis, myocarditis. Tablets are prescribed for follicular and lacunar tonsillitis. According to the instructions, adults take 500-700 mg twice a day. The course lasts until the symptoms are completely relieved (fever, abscesses on the tonsils, sore throat) plus two more days.

With sinusitis

Sinusitis is the inflammation of the paranasal sinuses in upper jaw. If it is caused by bacteria, the use of the antibiotic Flemoxin Solutab is justified. It is forbidden to use tablets if the disease is caused by viruses, fungi, allergies. Taking the drug helps to relieve fever, improve nasal respiration, eliminate swelling in the projection of the maxillary cavities, restore the sense of smell, stop headaches, and symptoms of general intoxication. According to the instructions, the tablets should be used within a week at a dose of 125-500 mg per day.

Flemoxin for bronchitis

According to the instructions, Flemoxin Solutab for bronchitis in children or adults is effective if the disease is of a bacterial nature. Indications for the use of tablets are heat more than 3 days in a row, signs of intoxication, difficulty breathing, increased leukocytosis. Flemoxin can be used for chronic purulent bronchitis.

With mild and moderate course of the disease, take 500-750 mg twice a day, children 3-10 years old - 375 mg twice a day. A child 1-3 years old is given 250 mg of the drug twice a day. The course of treatment lasts 5-7 days. In severe cases, the frequency of antibiotic intake increases to three per day, in the chronic stage - adults are prescribed 750-3000 mg three times a day, children - 60 mg / kg of body weight three times a day. With streptococcal lesions, the course of treatment lasts 10 days. After the symptoms are eliminated, you need to continue taking the medicine for another two days.

special instructions

Flemoxin Solutab 250 or 500 mg is prescribed with caution if you are prone to allergies. Other special instructions from the instructions:

1. The combination of amoxicillin with metronidazole is used with caution in patients under 18 years of age, and is prohibited in patients with liver disease.
2. Against the background of antibiotic therapy, alcohol intake is prohibited.
3. A history of erythroderma is not a contraindication to taking pills.
4. During therapy, the development of cross-resistance with cephalosporins, antibiotics from the penicillin group, the appearance of superinfection is possible.
5. If pseudomembranous colitis develops during treatment, the pills are canceled.
6. Patients with lymphocytic leukemia and infectious mononucleosis are more likely to develop non-allergic exanthema.

During pregnancy

Amoxicillin passes through the placenta, is found in breast milk, so the use of the drug during the bearing of a child or his breastfeeding may be used with caution and after careful weighing of benefits and risks. If the positive aspects of treatment for the mother outweigh the possible risk to the baby, then the use of the remedy is justified.

drug interaction

Flemoxin Solutab may be combined with certain medicines with caution. This is stated in the instructions for use:

1. Amoxicillin reduces the effectiveness of oral contraceptives based on estrogen.
2. The drug is an antagonist (reduces action) in relation to sulfonamides, tetracyclines, lincosamides, cycloserines, Chloramphenicol, macrolides. Shows synergism to cephalosporins, Rifampicin, aminoglycosides, Vancomycin, Cycloserine.
3. The drug enhances the effectiveness of indirect anticoagulants, inhibits the intestinal microflora, the synthesis of vitamin K.
4. Diuretics, Probenecid, non-steroidal anti-inflammatory drugs, Phenylbutazone, Allopurinol increase the concentration of the active substance in the blood plasma. Antacids, aminoglycosides, glucosamine and laxatives reduce its absorption, ascorbic acid increases it.

Side effects and overdose

Flemoxin Solutab 500 can lead to an overdose, which is manifested by nausea, vomiting, diarrhea. Her treatment consists of gastric lavage, taking saline laxatives, enterosorbents, correcting the balance of water and electrolytes. According to the instructions, possible side effects from taking the funds are:

• allergies, anaphylactic shock, urticaria, eosinophilia, erythema, joint pain, angioedema, fever, rhinitis, conjunctivitis;
• superinfection, swollen lymph nodes;
• agranulocytosis;
• anuria;
• convulsions, dizziness, peripheral neuropathy, ataxia, depression, confusion;
• disorders of hematopoiesis, nausea, interstitial nephritis, vomiting, pseudomembranous colitis, anorexia, stomatitis, diarrhea, glossitis, hepatitis, epigastric pain, constipation;
• dermatitis, erythema, necrolysis, dermatosis, impetigo;
• hyperthermia, body aches;
• jaundice.

Contraindications

Not all patients can safely take Flemoxin Solutab. The instruction highlights the following contraindications:

• Infectious mononucleosis;
• lymphocytic leukemia;
• dysentery;
• hypersensitivity to a component of the composition, penicillins, cephalosporins, nitroimidazole derivatives;
• severe infections of the gastrointestinal tract, accompanied by vomiting or diarrhea;
• hay fever;
• respiratory viral infections;
• bronchial asthma;
• allergic diathesis.

Terms of sale and storage

The drug is prescription, stored at temperatures up to 25 degrees for five years.

Analogues

Replace the drug can be means with the same or similar composition with a similar therapeutic effect. These are antibiotics.

• Amoxicillin - tablets based on the component of the same name;
• Ospamox - capsules, tablets or granules containing amoxicillin;
• Ampicillin - tablets, capsules, suspension and powder for injection based on the substance of the same name;
• Azlocillin sodium salt- tablets with the same component in the composition;
• Standacillin is a powder for the preparation of an injection solution based on ampicillin.

Price Flemoxin Solutab

You can buy the drug through pharmacies or the Internet at prices that depend on the concentration of the active ingredient per tablet and the number of pieces in the pack. Approximate cost in Moscow:

Video

The active substance Flemoxin Solutaba, as stated in the instructions for use, is represented by amoxicillin trihydrate.

Amoxicillin trihydrate is synthesized by a semi-synthetic penicillin substance with an antimicrobial, bactericidal effect on microorganisms.

Amoxicillin trihydrate is acid-stable, does not undergo destruction by the acidic contents of the stomach, and is activated immediately after ingestion in a short period of time.

The use of food, drinks does not cause a negative impact on the effectiveness of amoxicillin trihydrate, the achievement of the maximum effective concentration occurs after one hour. Due to the rapid interaction with blood transport proteins, Flemoxin is evenly distributed over the structural units of the whole body.

Flemoxin is highly effective against the following microbial organisms:

• streptococci (Str.pyogenes, Str.pneumonia);
• staphylococci (St.aureus);
• neisseria (N.meningitides, N.gonorrhoeae);
• hemophilic bacillus (H.influenza);
• clostridia (Cl.tetani, Cl.perfringens);
• helicobacter (Hel.pylori);
• listeria (Lis.monocytogenes).

The low efficacy of the drug has been proven by clinical studies in infections caused by Pr. Mirabilis, Sh.sonnei, En.faecalis, V.cholhere, Es.colli, Sal.typhii.

If we compare the drug with other antibiotics, Flemoxin is evenly distributed in the cell membranes of mucous membranes, muscle structures, musculoskeletal system, bronchopulmonary secretion, achieving effective therapeutic accessibility. The active substance is relatively poorly absorbed through the membrane of the blood-brain barrier of the brain, however, in cases of development of purulent meningitis, an infectious lesion of the anatomical structures of the central nervous system, the concentration of amoxicillin trihydrate is about 20% in the cerebrospinal fluid.

The metabolism of the drug is not much different from penicillin antibiotics.. Partially, the drug is metabolized by cells of the hepatic beams - hepatocytes, the formed metabolites of amoxicillin trihydrate do not have a toxic effect. The bacteriostatic activity of derivatives-metabolites of amoxicillin trihydrate after disintegration in hepatocytes is low.

Elimination of Flemoxin Solutab is carried out by the kidneys, of which 80% is tubular excretion, 20% is glomerular filtration of metabolites. If the patient does not have a violation of the filtration capacity of the renal tissue, the primary half-life of the drug takes no more than one and a half hours. In children with immature renal parenchyma, the elimination half-life is about three and a half hours.

note

The uniqueness of the pharmacological subspecies "Solutab" is the rapid absorption in the organs digestive system, absolute absorption (more than 94%).

Release form. Flemoxin is available in the form of white or yellowish dispersible tablets of 125, 250, 500 milligrams, 1 gram.

In addition to the active, excipients are presented in the form of:

• dispersible cellulose;
• lemon flavoring;
• crospovidone;
• saccharin;
• micro-crystalline cellulose;
• tangerine flavor additive;
• vanillin;
• magnesium stearate.

Dosing of the drug Flemoxin solutab, the instructions for use describe as follows: the drug is intended for oral administration, regardless of the time of planned food intake, before, during or after meals.

The dosage is divided into two halves, you can take the tablet completely, crush it to a powder state. Powder for children is recommended to be diluted with water to a state of suspension or syrup.

The antibiotic is prescribed strictly on the advice of the supervising doctor, which takes into account the manifestations of the patient's allergic reactions, drug intolerance to certain substances that make up the drug Flemoxin Solutab.

Instructions for use suggests adjusting the dosage of the drug depending on:

• the severity of the course of the disease;
• antibiotic sensitivity of the pathogen;
• weight;
• age;
• gender of the patient.

In cases of progression, the spread of primary inflammation for the distribution of Flemoxin to hard-to-reach localizations of the infection, three times the use of the drug is recommended. For example, with a purulent lesion of the eardrum of the outer ear. During various chronic infectious diseases, frequent relapses, severe course of the disease, to reduce the risk of complications, adults are prescribed Flemoxin gram three times, and children 65 mg / kg per day.

Indications for the use of the drug are infectious and inflammatory diseases caused by microorganisms sensitive to Flemoxin Solutab:

• lesions of the skin, subcutaneous fat, soft muscle tissue, joints;
• pathology of the urinary, reproductive systems;
• upper, lower infection respiratory tract, lung tissue;
• disorders of the digestive system.

Contraindications to the use of the antibiotic Flemoxin Solutab are few. due to the uniform distribution with the bloodstream through the organs and tissues of the body. The breakdown of amoxicillin into derivatives and metabolites significantly reduces the toxic effects on the liver and kidneys.

Absolute contraindications are:

• individual intolerance to the drug (anaphylactic shock);
• increased allergic sensitivity to the active substance of the drug (urticaria, pruritus, peeling);
• increased sensitivity to beta-lactam antibiotics, penicillins, cephalosporins, carbapenems.

The metabolism of amoxicillin by liver cells causes caution in the use of Flemoxin Solutab in the following conditions:

• alcohol abuse;
• chronic alcoholism;
• cirrhosis;
• acute and chronic liver failure;
• acute and chronic hepatitis;
• cholelithiasis;
• cholecystitis.

Excretion of the drug by the kidneys requires compliance with the dose of the drug, since a violation of the filtration function of the kidneys leads to the accumulation of the active substance and its metabolites, the risk of overdose increases.

Pathology from the kidneys:

• acute and chronic renal failure;
• pyelonephritis;
• glomerulonephritis;
• circulatory disorders.

• lactation period;
• pregnancy;
• polyvalent hypersensitivity to xenobiotics;
• diseases of the gastrointestinal tract in history;
• lymphocytic leukemia;
• kidney failure;
• infectious mononucleosis;
• allergic reactions in history.

For pregnant women or mothers during lactation, doctors prescribe the drug only in cases where the expected predicted benefit of treatment for a woman outweighs the risk of developing side effects in a fetus or infant. Flemoxin Solutab is excreted in small amounts with breast milk, this can lead to sensitization in a child, the development of allergic reactions.

Antibiotic Flemoxin Solutab and its therapeutic effect

The therapeutic bactericidal effect of the antibiotic Flemoxin Solutaba consists in the complete destruction of the infectious focus formed by gram-negative or gram-positive bacteria. After entering the human body, an acid-resistant antibiotic destroys most groups of infectious microorganisms, except for individual bacterial species capable of synthesizing the enzyme penicillinase.

Flemoxin Solutab is not used when the body is infected with indole-positive groups of the Proteus; in this case, a change in the drug is required for treatment.

The bactericidal effect of amoxicillin has been proven by domestic and foreign clinical studies.

Treatment of prostatitis with the antibiotic Flemoxin Solutab is widely used in urological practice. This is due to the rapid elimination of the inflammatory process of the prostate tissue, the removal of inflammatory edema, and the complete destruction of the pathogen. The effectiveness of the drug is achieved by individual selection of the daily dosage, a long course of therapy.

As a rule, with an infectious lesion of the prostate gland, antibiotic Flemoxin Solutab is prescribed to men with a course of at least 14 days, depending on the titer of pathogenic bacteria, general symptoms.

The drug quickly relieves the symptoms of general intoxication:

• weakness;
• lethargy;
• headache;
• chills;
• general malaise;
• temperature;
• pain when urinating;

Symptoms begin to disappear after the second dose of the drug, with an unfavorable prognosis of infection, the appointment of additional symptomatic therapy, anti-inflammatory nonsteroidal drugs. In acute prostatitis, the antibiotic Flemoxin Solutab is prescribed after bacterial seeding to accurately identify the pathogen.

The use of the drug for the treatment of other diseases, such as upper respiratory infections, is used quite often among general practitioners and otolaryngologists.

Good bioavailability of the drug in the mucous membranes of the nasopharynx allows you to treat diseases such as:

• purulent rhinitis;
• sinusitis (sinusitis, ethmoiditis, frontal sinusitis);
• polyposis;
• adenoiditis;
• sharp and chronic tonsillitis;
• various types of angina.

The antibiotic Flemoxin Solutab is prescribed both in childhood and in adulthood., after operations of the nasopharynx for a preventive effect, reducing the risk of infection. After opening the paratonsillar abscess, the drug is prescribed by a doctor to prevent secondary infection.

Flemoxin Solutab: dosage for adults and children

After the appointment of the drug Flemoxin Solutab, the dosage is determined by the attending physician, based on several criteria. Self-administration of drugs leads to the emergence of resistance in bacteria to antibiotics, persistent antibiotic resistance, which leads to the development of various complications and life-threatening pathologies.

This is due to non-compliance with dosing, fractional intake during the day, violation of the course of taking amoxicillin trihydrate. At inflammatory diseases mild and moderate severity, doctors recommend using Flemoxin Solutab regardless of meals according to the scheme, depending on the course of the disease:

• with mild adults, children from ten years old, 375-500 mg 3 times / day;
• with moderate adults, children from ten years old, 500-750 mg 2 times / day;
• children from three to ten years old with a lung, 250 mg 3 times / day;
• children from three to ten years old with moderate 375 mg 2 times / day;
• children of the first three with a lung, 125 mg 3 times / day;
• children of the first three years with moderate severity are prescribed 250 mg 2 times / day.

On average, the calculation of the drug per day is 25-31 mg amoxicillin per kilogram of the child's weight.

The resulting dosage is recommended to be divided into two or three doses., which improves the bioavailability of Flemoxin Solutab, increases its effectiveness, and the overall therapeutic effect. A triple dose is especially indicated for severe infections.

After the doctor's recommendations, the dosage of amoxicillin trihydrate can be increased to 65-80 mg per kilogram, this happens with extremely severe infections that are difficult to classical treatment. In such situations, pediatricians often combine Flemoxin Solutab in a dosage according to age with other representatives of antibiotic drugs.

In elderly people, amoxicillin trigdrate is dosed after a carefully collected anamnesis for pathology of the kidneys or the hepatocellular system. Depending on the degree of renal failure, which develops in many elderly people, the doctor adjusts the daily dose of the drug.

This avoids pathological toxic effects on body tissues, the occurrence of side effects. If there are complaints of feeling unwell, nausea, vomiting associated with the last use of the drug, it is urgent to seek advice from the supervising doctor to cancel it.

Pregnant women and mothers during lactation are prescribed Flemoxin Solutab after adjusting the dosage, assessing the rationality of the intake. Wide distribution in the tissues of the mother's body leads to the penetration of the active substance through the uteroplacental bloodstream to the fetus.

This significantly increases the development of allergic reactions in a child after birth. Teratogenic effect on the fetus when taking the drug during pregnancy according to the results of foreign clinical research not found.

Flemoxin Solutab: how to take, analogues, prices

Amoxicillin trigdrate is widely used among men suffering from prostatitis, which leads to a high absorption of Flemoxin Solutab by the prostate tissue. How to take this drug is advised in detail by a urologist immediately after laboratory tests, a general examination of the patient.

Prostatitis is characterized by a recurrent course with frequent exacerbations during the year. This is due to the poor absorption of the drugs used, antibiotics of the penicillin group. The positive effects in patients of the drug Flemoxin Solutab, which can be taken individually - orally in the form of tablets, powder for syrup or suspension, are achieved due to the complete destruction of bacterial cells.

The high effectiveness of the drug is evidenced by the long-term remission of prostatitis without exacerbations after administration. The next relapse, as a rule, develops after hypothermia of the patient, secondary infection, and acute respiratory viral infections.

note

The drug is especially effective in the treatment of prostatitis caused by Neisseria or Escherichia coli. A pronounced bactericidal effect blocks the production of microbial enzymes, completely eliminates the consequences of an infection of the prostate tissue.

In the treatment of otitis media, otolaryngologists prefer the drug because of its absorption by the tissues of the outer, middle and inner ear. While other antibiotics are not able to qualitatively fight the infection, Flemoxin Solutab blocks the reproduction of bacteria, quickly eliminates the unpleasant symptoms of otitis media.

In the treatment of bronchitis, the drug is used to quickly get rid of a wet cough with a discharge of purulent viscous sputum. Suitable for the prevention of exacerbations of chronic obstructive pulmonary disease. Does not violate the mucociliary clearance of the ciliated epithelium of the bronchi, does not cause allergic reactions. Administered with caution to patients bronchial asthma to avoid allergic reactions.

The analogues of the original drug are:

• Hyconcil.
• Gramox-D.
• Amoxicar.
• Grunamox.
• Amoxicillin.
• Ospamox.
• Gonoform.
• Danemox.
• Amosin.
• Ecoball.

Analogues are much cheaper, for example, the Austrian drug Hikoncil in capsules of 250 mg costs about 30 rubles. The domestic drug Amosin Synthesis in capsules of 250 mg costs 68 rubles.

Prices on original drug fluctuate depending on the region, form of release, dosage of the drug. The cost of the drug Flemoxin Solutab Ortat in tablets of 125 mg N20 starts from 230 rubles per pack. For a dosage of the drug 1000 mg of the same manufacturer, you can pay up to 560 rubles.

Antibiotics of the penicillin group, and in particular amoxicillin, are highly effective drugs for the treatment of bacterial infections of the respiratory tract, tk. extend their activity to a fairly wide range of pathogens. This is, in fact, a well-known fact. The original amoxicillin-based drug Flemoxin Solutab (hereinafter referred to as Flemoxin) from the Dutch pharmaceutical plant Astellas Europ is of particular interest: in addition to a wide spectrum of antibacterial action, it has pharmacokinetic and pharmacodynamic characteristics (bioavailability, absorbability, etc.) ), which, together with a unique dosage form - dispersible (soluble) tablets with apricot flavor - makes it popular among various age groups. To date, flemoxin is a first-line antibiotic in the treatment of acute infectious and inflammatory diseases of the ear / throat / nose and lower respiratory tract.

Flemoxin has a bactericidal effect against Gram-positive and Gram-negative bacteria such as Streptococcus pneumonia, Streptococcus pyogenes, Clostridium tetani, Neisseria meningitidis, Neisseria gonorrhoeae, Staphylococcus aureus (not producing the beta-lactamase enzyme), Listeria monocytogenes, Bacillus anthracis, Helicobacter pylori. The drug under certain conditions can be effective against Escherichia coli, Enterococcus faecalis, Salmonella typhi, Proteus mirabilis, Shigella sonnei, Vibrio cholerae.

Taking flemoxin does not make sense for infections caused by bacteria that produce beta-lactamase, as well as Pseudomonas spp., Indole-positive Serratia spp., Proteus spp., Enterobacter spp.

Flemoxin is stable in the acidic environment of the stomach. When taken orally, it is very quickly, regardless of food intake, absorbed and distributed in the body. Available only in the form of dispersible tablets, which are allowed to be swallowed, divided into parts or chewed, while drinking water. As for the main method of using Flemoxin tablets - dissolution, water is used for this in a volume of 20 ml (final product - syrup) or 100 ml (suspension). By general recommendations adults and children over the age of 10 years use 500-750 mg of the drug twice or 375-500 mg three times a day. With the features of the use of the drug in specific diseases, as well as in young children, see the leaflet. The duration of antibiotic therapy for mild and moderate infections is about 5-7 days, and in cases of infections caused by Streptococcus pyogenes - 10 days. disappearance clinical manifestations disease is by no means a signal for the immediate withdrawal of the drug: it should be taken for another 2 days. If the use of flemoxin is accompanied by severe diarrhea, then the presence of pseudomembranous colitis can be assumed. In such cases, the drug must be canceled.

Pharmacology

Bactericidal acid-resistant broad-spectrum antibiotic from the group of semi-synthetic penicillins. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria.

Active against gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing β-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori.

Less active against Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae.

Not active against microorganisms producing β-lactamase, Pseudomonas spp., Proteus spp. (indole-positive strains), Serratia spp., Enterobacter spp.

Penicillinase-producing strains are resistant to the action of amoxicillin.

Pharmacokinetics

Suction

After oral administration, amoxicillin is absorbed quickly and almost completely (93%), and is not destroyed in the acidic environment of the stomach. Eating has practically no effect on the absorption of the drug. After ingestion of 500 mg of amoxicillin, C max of the active substance, which is 5 μg / ml, is observed in blood plasma after 2 hours. With an increase or decrease in the dose of the drug by 2 times, C max in blood plasma also changes by 2 times.

Distribution

Plasma protein binding is 17%. Amoxicillin penetrates the mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In the amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicillin does not penetrate well through the BBB; however, in inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma.

A small amount is excreted in breast milk.

Metabolism

Amoxicillin is partially metabolized in the liver, most of its metabolites are not microbiologically active.

breeding

Amoxicillin is excreted by 50-70% by the kidneys unchanged (by tubular excretion - 80% and glomerular filtration - 20%), by the liver - 10-20%.

In the absence of impaired renal function, T 1/2 of amoxicillin is 1-1.5 hours. In premature babies, newborns and children under 6 months - 3-4 hours.

Pharmacokinetics in special clinical situations

T 1/2 amoxicillin does not change in violation of liver function.

In case of impaired renal function (CC ≤ 15 ml / min), T 1/2 amoxicillin increases and reaches 8.5 hours with anuria.

Amoxicillin is removed from the body during hemodialysis.

Release form

Dispersible tablets from white to light yellow, oval, with the company logo and the digital designation "236" on one side and a score dividing the tablet in half on the other side.

Excipients: dispersible cellulose - 34.8 mg, microcrystalline cellulose - 50.5 mg, crospovidone - 50.4 mg, vanillin - 1 mg, tangerine flavor - 9.1 mg, lemon flavor - 11.1 mg, saccharin - 13.1 mg, magnesium stearate - 6 mg.

5 pieces. - blisters (4) - packs of cardboard.

Dosage

The drug is taken orally. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml) with a pleasant fruity taste.

The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

In the case of infectious and inflammatory diseases of mild to moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years old are prescribed 500-750 mg 2 times / day or 375-500 mg 3 times / day; children aged 3 to 10 years are prescribed 375 mg 2 times / day or 250 mg 3 times / day; children aged 1 to 3 years are prescribed 250 mg 2 times / day or 125 mg 3 times / day.

The daily dose of the drug for children (including children under 1 year old) is 30-60 mg / kg / day, divided into 2-3 doses.

In the treatment of severe infections, as well as in hard-to-reach foci of infection (for example, acute otitis media), a three-time dose is recommended.

In chronic diseases, recurrent infections, severe infections, adults are prescribed 0.75-1 g 3 times / day; children - 60 mg / kg / day, divided into 3 doses.

In acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid.

In case of infections of mild and moderate severity, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.

The drug should be continued for 48 hours after the disappearance of the symptoms of the disease.

Overdose

Symptoms: dysfunction of the gastrointestinal tract - nausea, vomiting, diarrhea; The consequence of vomiting and diarrhea may be a violation of the water and electrolyte balance.

Treatment: prescribe gastric lavage, activated charcoal, saline laxatives; apply measures to maintain water and electrolyte balance, hemodialysis.

Interaction

Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone inhibit the tubular secretion of penicillins, which leads to an increase in T 1/2 and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) show synergism when taken simultaneously.

Possible antagonism when taken with some bacteriostatic drugs (eg, chloramphenicol, sulfonamides).

Simultaneous use of amoxicillin with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.

Antacids, glucosamine, laxatives medicines, aminoglycosides, food reduce absorption. Ascorbic acid increases absorption.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); enhances the absorption of digoxin.

The simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.

Side effects

From the digestive system: rarely - a change in taste, nausea, vomiting, diarrhea, dysbacteriosis, stomatitis, glossitis; in some cases - a moderate increase in the activity of hepatic transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis.

From the urinary system: the development of interstitial nephritis, crystalluria.

From the hemopoietic system: leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia.

From the nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic convulsions.

Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash, urticaria, skin flushing, erythematous rashes, rhinitis, conjunctivitis, erythema multiforme exudative (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions, similar to serum sickness, toxic epidermal necrolysis, allergic vasculitis, acute generalized exanthematous pustulosis; in some cases - anaphylactic shock, angioedema.

Other: difficulty breathing, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections;
• infections of the genitourinary system;
• infections of the digestive tract;
• skin and soft tissue infections.

Contraindications

• hypersensitivity to the components of the drug;
• hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.

With caution, the drug should be used with polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, a history of gastrointestinal diseases (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and lactation, allergic reactions (including in history).

Application features

Use during pregnancy and lactation

The use of the drug Flemoxin Solutab ® during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.

In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization phenomena in an infant.

Application for violations of kidney function

Use in children

It is used in children according to indications according to the dosing regimen.

special instructions

The drug should be prescribed to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of non-allergic exanthema.

The presence of erythroderma in history is not a contraindication for the appointment of the drug Flemoxin Solutab ® .

Cross-resistance with penicillins and cephalosporins is possible.

The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibiotic therapy.

At treatment of mild diarrhea against the background of course treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals can be used. Treatment necessarily continues for another 48-72 hours after the disappearance clinical symptoms diseases.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods contraception.

Influence on the ability to drive vehicles and control mechanisms

No adverse effect of the drug on the ability to drive was reported. vehicles or working with machinery.