It is usually not used as a single drug in the treatment inflammatory diseases liver. The drug Sofosbuvir appeared on the world market in 2013 under trade name"Sovaldi"

But the effectiveness of these drugs largely depends on the degree of liver fibrosis. Sofosbuvir is the first drug of its kind that can cure hepatitis C of any genotype.

About the drug

The medicine "Sofosbuvir" is an antiviral tablet that suppresses the replication (multiplication) of viruses. In 2013, the US Drug Administration approved the use of the drug in non-injection therapy for viral hepatitis. The combination of Sofosbuvir with other drugs allows you to treat a disease of any severity without the use of Interferon Alpha, which often causes adverse reactions.

Manufacturer

Gilead Science is an American pharmaceutical company that produces the original Sofosbuvir tablets under the trade name Sovaldi. After clinical trials and confirmation of the effectiveness of the drug, the manufacturer announced that it would issue licenses to many countries in Europe and Asia to produce the antiviral drug.

Glead Science is the official manufacturer of Sofosbuvir, which has been issued a license for the production of drugs by the Indian companies Natco Pharma and Zydus.

SOFOVIR, MYHEP and Hepcinat are the most famous generics of Sofosbuvir, which are produced by Indian pharmaceutical companies. The medicines have undergone all kinds of clinical tests and tests, on the basis of which the most effective schemes treatment of viral hepatitis.

Natco Pharma is the most famous pharmaceutical manufacturer in India, which has received a license to produce a new antiviral drug. Natco is an advanced pharmaceutical company with high-tech equipment. She became famous for her numerous developments and research in the field of pharmaceuticals.

The Indian manufacturer received permission to produce and sell the new generic Harvoni, which includes Ledipasvir and Sofosbuvir. The innovative drug is used to treat hepatitis C genomes 1 and 4. In 2015, Natco Pharma released another antiviral drug, Natdac, which was developed on the basis of Daclatasvir.

Zydus is the fourth largest Indian drug manufacturer and has a license to manufacture Sofosbuvir. All medications produced by the company are certified according to international standards and are therefore absolutely safe. Zydus specializes in the promotion of generic drugs, which in their therapeutic properties are not inferior to the original drugs.

Release form and composition of the drug

The drug for hepatitis is available in the form of tablets coated with a special glaze. They have a bitter taste, so the protective coating prevents irritation of the esophageal mucosa during oral administration of the medicine. Sofosbuvir contains the following components:

• magnesium stearate;
• titanium dioxide;
• colloidal silicon dioxide;
• polyvinyl alcohol;
• croscarmellose sodium;
• mannitol;
• red iron oxide;
• sofosbuvir;
• polyethylene glycol.

"Sofosbuvir tablets" 400 mg take 1 tablet no more than twice a day. The course of treatment largely depends on the degree of fibrosis of the liver tissue and varies from 12 to 24 weeks.

News from around the world confirms the effectiveness of the drug, the therapeutic effect of which was determined experimentally. In 2013, a direct-acting antiviral drug was included by WHO in the list of medications necessary for the treatment of patients with viral hepatitis.

Operating principle

The mechanism of action of the drug is based on the inhibition of nucleic acids contained in pathogens. In other words, the drug Sofosbuvir contains substances that inhibit the synthesis of RNA polymerase, which prevents the replication (self-copying) of viral RNA. When entering the body of an infected person, the components of the drug block the production of enzymes necessary for the reproduction of pathogenic agents.

Completion of complex therapy with the use of Sofosbuvir allows one to achieve a sustainable virological response in the treatment of patients in 92% of cases.

According to doctors, “Sofosbuvir 400” is advisable to use when hepatitis transitions to chronic form. It can be used in the treatment of liver diseases accompanied by malignancy of hepatocytes (hepatocellular carcinoma) or immunodeficiency virus.

Instructions for use

Treatment with Sofosbuvir should be carried out under the supervision of specialists with experience in the treatment of viral hepatitis. It is recommended to use the drug in combination with other medications with hepatoprotective and anti-inflammatory effects.

Instructions for use of Sofosbuvir

The antiviral agent should be taken once a day, 1 tablet (400 mg) with meals, with plenty of water. It is not recommended to cut the tablet, dissolve it in water, or crush it. The pills have an unpleasant bitter taste and therefore can irritate the esophageal mucosa if their protective shell is damaged.

Mode of application

When undergoing antiviral therapy, you must strictly follow your doctor's recommendations. As a rule, at the beginning of treatment, taking the medicine causes nausea or vomiting in patients. If vomiting occurs within 2 hours after taking the drug, you need to take an additional pill.

There is no description of the drug produced by Glead Science in Russian. But the Indian generic Sofosbuvir most often has package inserts translated into Russian. For this reason, the medicine is used exclusively on the recommendation of the attending physician, taking into account the characteristics of the course of the disease.

Duration of use

Treatment with an antiviral drug is carried out for 12 weeks or more. The duration of therapy is determined by the intensity of inflammatory processes in the liver and the genotype of the disease. In most cases, hepatitis C genotype 1 is treated for no more than 12 weeks, but if there is no expected therapeutic result, therapy can be extended for 1 or more weeks.

Drug interactions

Treatment original tablets Sovaldi is always accompanied by taking additional medications. But if the patient suffers from concomitant pathologies (hypertension, diabetes, HIV), the treatment regimen has to include medications from other pharmacological groups. The use of additional medications is permitted only in situations where, according to medical data, the benefit many times outweighs the possible complications.

“Hepcinat”, “Grateziano” and “Viropak” are analogues of the original drug, certified according to international standards.

According to expert reviews, the instructions for Sofosbuvir do not contain comprehensive information about the drug. In this regard, disappointing news is increasingly appearing about the deterioration of the health of patients who combine taking pills with other medications. Doctors categorically do not recommend combining the use of Sovaldi with glycoprotein inducers, which include Phenytoin, Rifamycin, Carbamacepin, etc.

Only the attending physician can determine the compatibility of Sofosbuvir with other medications. As practice shows, it is not always possible to combine the drug even with those medications that were previously included in the standard hepatitis treatment regimen.

This applies in particular to Boceprevir.

The compatibility of Sofobuvir with other drugs depends on the principle of action and pharmacological properties the latter. When undergoing a 12-week course of treatment, it is contraindicated to take antiarrhythmic drugs (Amiodarone), because they can cause irreversible processes in the body and even the death of the patient.

Interaction with alcohol

Is it possible to combine Sofosbuvir and alcohol? The manufacturer categorically does not recommend drinking alcoholic beverages during the course of therapy. Ethanol, which is contained in alcohol, reduces the effectiveness of the drug and negatively affects the functioning of the liver.

The constant circulation of ethanol in the body leads to the development of visceral lesions and an increase in the concentration of gamma-HT serum in the blood, which negatively affects the therapeutic effect of the drug. In other words, sofosbuvir and alcohol are incompatible things. Patients who abuse alcohol reduce the effectiveness of antiviral treatment by 40% or more. Complete abstinence from alcoholic beverages leads to a significant improvement in treatment results and, as a result, regression of inflammation in the liver.

Features of therapy

The Sofosbuvir treatment regimen is determined by the stage of development of viral hepatitis, the degree of parenchymal fibrosis and associated complications. If you follow the recommendations of a specialist, it is allowed to combine the drug with anticoagulants, antihypertensive drugs and calcium channel blockers. Treatment of hepatitis occurring against the background of HIV infection is carried out with the help of antiviral drugs and some immunosuppressants.

Standard therapy regimen

The standard treatment regimen for hepatitis C with Sofosbuvir includes medications that have an antiviral effect against respiratory sensitisation and parenteral viruses:

Form of the disease	Possible treatment regimens	Duration of treatment
hepatitis C genotype 1	"Sofosbuvir" - "Ribavirin" - "Peginterferon"	12 weeks
hepatitis C genotype 2	"Sofosbuvir" - "Ribavirin" ("Simeprevir")	12 weeks
hepatitis C genotype 3	"Ledipasvir" - "Viropak" - "Daklatasvir"	12 weeks
hepatitis C genotype 4	"Peginterferon" - "Sofobuvir" - "Ribavirin"	12-24 weeks
hepatitis C complicated by cirrhosis of the liver	"Sovaldi" - "Ledipasvir" - "Ribavirin"	24 weeks
hepatitis C complicated by HIV infection	"Sofosbuvir" - "Ribavirin" - "Daklatasvir"

As a rule, Sofosbuvir and Ribavirin form the basis for the treatment of viral hepatitis of almost all genotypes. If the effectiveness of treatment is relatively low, additional drugs are used, such as Peinferon, Ledipasvir, Simeprevir, etc.

Sofosbuvir 400 mg is taken in courses of 12, 16 and 24 weeks, 1 tablet per day. The duration of therapy depends on the rate of regression of viral inflammation and the functioning of the liver.

Hepatitis C genotype 3 is often complicated by cirrhosis, so hepatoprotectors may additionally be included in the treatment regimen. In addition, patients are advised to adhere to a dietary regimen that reduces the load on the detoxification organs.

After treatment with Sofosbuvir, the patient must undergo all necessary laboratory tests. If the test results show that the viral load on the liver is zero, the remaining period of therapy is doubled. In other words, the patient should be treated for 2/3 of the course with a zero viral load. According to most experts, this prevents relapses of inflammation and complications.

Diet for hepatitis

Proper nutrition can reduce the load on the liver affected by inflammation and thereby increase the effectiveness of therapy. First of all, the patient must completely abstain from alcohol. It contains ethanol, which has a pronounced toxic effect. An increase in the concentration of toxins in the bloodstream leads to the death of hepatocytes and, as a consequence, the development of cirrhotic processes.

The therapeutic diet includes natural products that do not contain preservatives, synthetic colors or flavor enhancers. Changing the diet requires willpower from the patient, but compliance with it really has a significant impact on the state of health and the dynamics of recovery.

With hepatitis, sugar consumption should be kept to a minimum, as it puts a strain on the pancreas, which promotes the replication of viral RNA.

Based on medical news and reviews from patients who have undergone pathology treatment, the following foods should be excluded from the diet:

• flour products;
• conservation;
• wheat;
• fruit juices;
• dairy products;
• artificial sweeteners;
• fat meat;
• confectionery.

According to nutritionists, unhealthy foods should be replaced with fresh vegetables and fruits, lean meats and soy cheese. Whole wheat bread is a good alternative to flour products. Carbonated drinks and alcohol can be replaced with lemonade (still), herbal teas, etc.

How to distinguish an original from a fake

News about the effectiveness of the new antiviral drug reached not only doctors and patients, but also scammers. In this regard, counterfeits have appeared on the Russian market over the past few years, which are not analogues of the original drug and do not have the stated therapeutic effect. Original drug"Sovaldi" can be purchased in an online pharmacy from the official manufacturer, as well as in regular pharmacies in major cities of the country.

To avoid becoming victims of scammers, before purchasing you need to check not only the drug, but also the seller who sells it. How to distinguish an original from a fake? First, check that the seller has the necessary documents:

1. certificates confirming the right to sell pharmaceutical products;
2. licenses allowing the distribution of a specific drug within the country;
3. information about the official dealer and supplier medical supplies with contact phone number and actual address;
4. export-import documents with which you can confirm the legitimacy of the delivery.

How to distinguish a fake by visual inspection? Manufacturers strive to take all kinds of safety measures that have helped prevent the purchase of non-original medicine. To avoid buying a fake, during a visual inspection you need to pay attention to the following points:

• the presence of holographic foil on the neck of the drug;
• tightness and integrity of packaging;
• identity of serial numbers on the packaging and jar of tablets;
• instructions for use of the medicine, written in English.

Failure to comply with the above points most often indicates falsification of medical products.

Side effects and contraindications

Sovaldi very rarely causes side effects. As a rule, unwanted reactions occur when several antiviral agents are used simultaneously. When undergoing drug therapy, patients most often complain of:

Side effects of Sofobuvir most often occur in patients who do not follow recommendations for the use of antiviral agents. Undesirable reactions can be prevented if the drug is taken in a dosage strictly determined by the doctor.

It should be noted that Sovaldi and its analogues have contraindications for use that must be taken into account. It is not advisable to use medications during pregnancy and lactation, as well as for persons under 18 years of age. Hepatic and renal failure- direct contraindications to the use of potent drugs. Antiviral therapy should be used with caution in elderly people suffering from chronic diseases.

Opinion of doctors and patients

News about the effectiveness of the antiviral drug spread throughout the world over several years. According to reviews from doctors, Sofosbuvir is the only medication of its kind, the use of which in 98% of cases guarantees recovery from hepatitis C. Sovaldi is a safe medicine that eliminates foci of inflammation in parenchymal tissue, but has virtually no contraindications for use .

In general, the opinion of experts coincides with the reviews of patients who were treated for hepatitis C with Sofosbuvir:

• Vladimir, 24 years old. I was diagnosed with hepatitis of the third genotype just at the moment when generics began to appear in pharmacies. I was able to purchase the drug without any problems and complete the entire course of treatment. Fortunately, I managed to recover before the symptoms of the disease made themselves felt.
• Olga, 27 years old. Now I am being treated with the Indian drug Sofosbuvir, so far there are no complaints. Sometimes it makes me feel nauseous, but compared to possible complications hepatitis is just flowers. I was very afraid that the treatment would give me a runny nose, because the drug was new and I didn’t have any friends who could know anything about it. I recently took tests, which revealed that the viral load on the liver has decreased by half, and yet I have been taking the medicine for no more than 3 weeks. The doctor said that one course of therapy would be enough to completely cure hepatitis.

Treatment with the original antiviral drug and generics requires compliance with precautions and dosages recommended by experts. The effectiveness of therapy depends on the stage of development of hepatitis and its genotype. Early diagnosis and proper preparation of a treatment regimen allows you to completely eliminate the virus and prevent the formation of fibrous adhesions in the parenchymal tissue. Timely use of Sovaldi, moderate physical exercise And proper nutrition promotes rapid regression of inflammation and restoration of liver function.

Sofosbuvir and Daclatasvir - antiviral drugs, used to treat viral hepatitis C of all genotypes. One Sofosbuvir tablet contains the active ingredient sofosbuvir in an amount of 400 mg. Daclatasvir – tablets containing 60 mg active substance daclatasvir.

Excipients

The original medicine includes both main components and additional ones, the role of which is to form the tablet shell and enhance the effect of taking the active substance.

Description of the composition of the Sofosbuvir tablet shell:

• polyethylene glycol;
• iron oxide;
• titanium dioxide;
• talc;
• alcohol.

Tablet:

• croscarmellose sodium;
• colloidal silicon dioxide;
• magnesium stearate;
• mannitol;
• microcrystalline cellulose.

Important. The drug is not monotherapy and is combined with other medications, in particular with Daclatasvir.

Description of the composition of Daclatasvir tablet:

• film shell with a green tint;
• daclatasvirdihydrochloride;
• magnesium stearate;
• cellulose;
• silica;
• croscarmellose sodium.

The original instructions in Russian suggest taking a complex of drugs according to the regimen prescribed by the doctor. In this case, patient reviews of treatment are positive in 90% of cases, regardless of the genotype of the virus that causes the disease.

Dosage form

Both drugs are available in tablet form.

Sofosbuvir is an oval-shaped tablet with a brown tint. Daclatasvir – round tablets in a film shell of a greenish tint.

Pharmacodynamics

The active substance Daclatasvir is an inhibitor of viral protein 5A (NS5A) and performs a protective function. It prevents the virus from damaging healthy cells. It is prescribed in combination with other antiviral drugs, in particular with Sofosbuvir, which is an inhibitor of the NS5B protein, which blocks not only the reproduction of the pathogen, but also its spread. As a result, the replication process stops, which leads to the death of the virus. Drug therapy has been shown clinical researches and patient reviews, it is effective in almost all cases.

Pharmacokinetics

The drugs + Daclatasvir are absorbed almost immediately after ingestion. The medicine should be taken with meals, with plenty of water. Sofosbuvir and Daclatasvir, official instructions regulates dosage regimens and duration of treatment, does not require dosage changes in the presence of other diagnosed diseases. The advisability of taking it, completely stopping the drug or changing the general treatment regimen is possible if the patient is diagnosed with cirrhosis of the liver, HIV infection, or individual intolerance.

Indications for use

Both active ingredients are included in many drugs, both original, Sovaldi, Daklinza and generics. Among them are Sofovir Sofosubvir, Daclahep Daclatasvir. Generics are not inferior in quality and properties, which is confirmed by the official instructions for use of Sofosbuvir and Daclatasvir. Their demand is quite explained by their cost. The price for original products is too high and is not affordable for everyone. Generics are much cheaper.

The main indications for taking the medicine are:

• diagnosed hepatitis C 1 – 4 genotypes;
• the presence of chronic hepatitis C with coinfection with HIV;
• chronic hepatitis C with liver cirrhosis;
• persons over 18 years of age with clear indications.

Contraindications for use

Sofosbuvir and Daclatasvir should not be taken in the following cases:

• pregnant women;
• during lactation;
• patients whose age is less than eighteen years old, since the effect of the drug on children’s and youth’s bodies has not been identified;
• individual intolerance to one of the substances;
• if the patient is already taking medicine, which contains one of the active substances.

Women of reproductive age should take the drug with caution. If you need to take any medications in parallel, consult your doctor first, as the effect of therapy may be reduced.

Side effects

Even if the instructions for Sofosbuvir are fully followed, side effects may occur in the form of the following symptoms:

• dizziness or headache;
• weakness;
• loss of appetite;
• drowsiness;
• dry skin;
• diarrhea;
• irritability;

When the first symptoms appear, be sure to notify your doctor. It may be necessary to adjust the course of treatment or discontinue the medicine altogether.

Treatment regimen for chronic hepatitis C

Sofosbuvir and Daclatasvir, the instructions in Russian show the method of administration, have a fairly simple prescription regimen. If indicated, one tablet is prescribed once a day at approximately the same time. In some cases, the doctor prescribes a third drug, Ribavirin, to accompany the complex.

The main treatment regimen is indicated in the tables:

Table 1

table 2

Table 3

Equipment

The drug is packaged in individual packages of 28 tablets each. Along with the medicine, instructions are provided in the kit.

Storage conditions

The generic is stored in a dark, dry place, out of reach of small children, for the time specified by the manufacturer on the packaging. After the expiration date, the use of the drug is prohibited.

Where can I buy drugs to treat hepatitis C?

Today you can buy a generic drug in Russia at an affordable price. You can order medications on the website or by phone. Please check delivery times when ordering. There are several generics in stock that contain this combination.

Price of medicines

Our company's assortment includes high-quality drugs for the treatment of hepatitis C. Each client can choose exactly what he needs. Prices are indicated in the catalogue. Follow our news as we regularly hold promotions for the purchase of a course of therapy.

Hepatitis C is dangerous disease, which can lead to irreversible consequences. On initial stages Symptoms of the disease hardly appear, so in most cases the disease is detected in a chronic form.

The disease is caused by the HCV virus, which multiplies in the human body using special enzymes. It is sofosbuvir that can stop the synthesis of the genetic chains of the virus. The new generation drug is available in tablet form. It is only effective in combination with other antiviral drugs. It is not used as monotherapy.

Sofosbuvir is a new generation drug that is radically different from its predecessors. You should pay attention to the main advantages of modern medicine:

• Duration of therapy: the course varies from three to six months depending on the course of the disease.
• After 12 weeks, a sustained virological response is usually observed.
• Efficiency is 99%.
• Manifestation side effects in rare cases.
• Minimal number of contraindications.
• Treatment is possible in difficult situations (in the presence of liver cirrhosis or human immunodeficiency virus).
• Affordable price, thanks to which every patient has a chance of salvation.

The treatment regimen for hepatitis C involves the use of sofosbuvir in combination with other antiviral drugs, which can be prescribed by a specialized specialist.

Several years ago, the principles of treatment for hepatitis C changed dramatically - in 2011, new direct-acting antiviral drugs were patented abroad.

Composition and dosage form

The drug is available in the form of coated tablets, thanks to which they dissolve directly in the stomach.

Sofosbuvir contains:

• active substance, that is, sofosbuvir;
• colloidal silicon dioxide;
• magnesium stearate;
• croscarmellose sodium;
• mannitol;
• microcrystalline cellulose.

The shell includes:

• polyethylene glycol;
• titanium dioxide;
• iron oxide;
• talc;
• alcohol.

Indications

Sofosbuvir is prescribed as part of complex antiviral therapy:

Contraindications

• Age up to 18 years;
• Women during pregnancy and lactation (the effect of the drug on the fetus and the body of young children has not been studied);
• Patients with hypersensitivity to the active ingredient.

The drug is prescribed with caution:

• women of childbearing age, since its effect on reproductive functions unknown for certain;
• patients who have undergone surgery (after liver transplantation), since the effectiveness and safety of sofosbuvir in this case has not been established.

Limitations in use

Patients diagnosed with liver or kidney failure, as well as patients over 65 years of age, undergo antiviral therapy under the constant supervision of the attending physician throughout the course.

Severe renal failure and terminal stage chronic renal failure

Treatment regimens and dosage

The drug is used exclusively with other drugs, in no case as monotherapy. The tablets are taken orally once a day, preferably during meals with plenty of liquid.

The daily dose is 400 mg/1 tablet. It is not recommended to reduce the dose of the drug. The course of treatment is 12-24 weeks.

Treatment regimen for Hepatitis C for all genotypes:

Genotype 1

For genotypes 1a and 1b, in the absence of liver cirrhosis and previous treatment, a course of 12 weeks is prescribed. The most effective combinations of drugs (95-99%) are:

• Sofosbuvir and Daclatasvir;
• Sofosbuvir and Ledipasvir;
• Sofosbuvir and Velpatasvir.

In the presence of compensated cirrhosis and the absence of previous therapy, the following regimens should be followed:

• Sofosbuvir and Daclatasvir: course - 24 weeks;
• Sofosbuvir and Ledipasvir: course - 12 weeks;

Genotype 2

In the absence of cirrhosis and prescribing therapy for the first time, one should be guided by the following combinations:

• Sofosbuvir and Daclatasvir: course - 12 weeks;
• Sofosbuvir and Velpatasvir: course - 12 weeks.

If compensated cirrhosis is detected and there is no previous treatment, the most optimal options the following are considered:

• Sofosbuvir and Velpatasvir: course - 12 weeks.
• Sofosbuvir and Daclatasvir: course - 24 weeks.

Genotype 3

If a third genotype is detected, experts recommend using the same combinations of drugs as for the second genotype of the virus. The duration of therapy depends on the presence or absence of cirrhosis, as well as on the lack of early treatment.

Genotype 4

If the patient has not previously taken any drugs against hepatitis C, the course duration will be 12 weeks. The following combinations are recommended:

• Sofosbuvir and Ledipasvir.

The presence of cirrhosis does not affect the effectiveness of the chosen regimen.

Genotype 5

The greatest effectiveness is achieved when using the following combinations:

• Sofosbuvir and Veltapasvir;
• Sofosbuvir and Ledipasvir.

A 12-week course is prescribed for patients who have not previously undergone treatment and in the absence of cirrhotic changes.

Genotype 6

In this case, the same treatment regimens are used as for the fifth genotype of the virus. As practice shows, the combination of sofosbuvir and velpatasvir is 100% effective in such cases. Tandem with ledipasvir helps in 96% of cases. The regimens can be used in the presence or absence of cirrhosis.

Treatment of patients with liver cancer awaiting organ transplantation

To prevent re-infection with the virus in the postoperative period (after transplantation), the recommended period of taking the Sofosbuvir + Ribavirin drug complex is no more than 48 weeks or before the operation, if it is planned for an earlier date.

All of the above diagrams are presented for reference. In each case, drugs are prescribed individually, taking into account the type of virus, the characteristics of the course of the disease and the patient’s condition.

Side effects

In rare cases, side effects occur:

• Nausea and vomiting;
• Headache;
• Decreased appetite;
• Irritability and anxiety;
• Fast fatiguability;
• Intestinal upset and bloating;
• Dry skin;
• Anemia;
• Sleep problems.

In most cases, adverse reactions disappear on their own within a week. If your health worsens, you should consult your doctor.

In the event of severe body reactions associated with taking Ribavirin, its dosage may be reduced or the drug may be discontinued until they disappear or the intensity level decreases.

Below is a table showing when you should stop taking ribavirin:

Laboratory data Reduce ribavirin dose to 600 mg per day Discontinue ribavirin

Hemoglobin levels in patients without cardiovascular disease<10 г/дл <8,5 г/дл

Hemoglobin level in patients suffering from cardiovascular diseases Decrease in hemoglobin by more than 2 g/dl after 4 weeks of treatment Despite taking a lower dose of the drug for 4 weeks, the hemoglobin level is less than 12 g/dl

Important. In case of discontinuation of drugs included in the treatment complex, Sofosbuvir is also discontinued.

Interaction with other medications

Taking Sofosbuvir in parallel with other medications may result in a decrease in the effectiveness of antiviral therapy or cause a negative reaction in the patient. If you need to take other medications, be sure to notify your doctor.

Important. Prescription in combination with drugs such as verapamil, nicardipine, nifedipine and felodipine is carried out under ECG monitoring.

Reception with Telaprevir and Boceprevir is undesirable.

If the patient has a history of other chronic diseases that require constant use of certain medications, a mandatory consultation with a doctor is necessary.

Overdose

To date, cases of drug overdose have not been described. The maximum dose that was administered to volunteers in the clinical study (1200 mg) did not cause undesirable effects. The identified side effects did not differ in frequency and severity from those that occur in patients with standard use of the drug.

A specific antidote for an overdose of Sofosbuvir is not used (absent). If this problem occurs, the doctor prescribes symptomatic treatment, provides observation, clinical and (if necessary) hardware examination.

Equipment

The drug is available in the form of tablets, which are packaged in polymer jars. One package contains 28 tablets. Sold in original containers with protective film on the neck. Instructions for use are included.

Storage conditions

The medicine must be stored at a temperature of +15 +30 degrees Celsius in a dry place out of reach of children. It is recommended to avoid direct sunlight

Best before date

The release date and shelf life (2 years) are indicated by the manufacturer on the packaging. It is strictly forbidden to use the medicine after the expiration date.

If the integrity of the packaging or protective film is damaged, the use of the drug is unacceptable.

You can check all details regarding ordering and delivery with our managers by phone. The price of Sofosbuvir is indicated on the website. Exact information can be obtained immediately before ordering.

How to purchase the drug?

Currently in Russia at an affordable price you can visit our company’s website. We provide delivery throughout the country, so the location of our customers does not matter to us. We work without prepayment, so you can be confident in our integrity. Delivery throughout the country is carried out by EMS Russian Post and takes 3-7 working days.

Orders can be placed on the website around the clock. We work every day, seven days a week, so as soon as possible after receiving your application, our operators will contact you to clarify details. On our website you can buy sofosbuvir inexpensively, both as part of a complex drug and as a monodrug. If you have any questions, please contact us at the telephone number provided.

Price: where is the best place to shop?

The World Health Organization has approved sofosbuvir as a drug against viral hepatitis C. Unfortunately, the cost of the original medicine is enormous, so only a few can afford it. Indian generics are drugs that are affordable for Russians. The cost of the course varies from several hundred to two thousand dollars, depending on the drugs chosen.

The price of sofosbuvir also depends on what strategy the doctor chooses for a particular patient. This component is produced by several pharmaceutical companies in India, so its price varies depending on the trade name. In any case, we offer the best price for sofosbuvir in Moscow and throughout Russia. Call, place orders, receive medications, undergo therapy and get well!

Sofosbuvir and daclatasvir are antiviral substances included in the most common treatment regimen for hepatitis C. The main advantage is the possibility of using the combination for the most common HCV genotypes. At the same time, taking medications is not accompanied by significant side effects, and the main list of contraindications includes only a few diseases.

Sofosbuvir has become a second-generation direct-acting antiviral drug. At first, the drug was used in combination with ribavirin, and sometimes interferon was added to the therapy protocol. Thus, it was possible to achieve a successful virological response in 60-80% of cases. However, it was still impossible to avoid frequent adverse reactions.

Daclatasvir has been approved for use in Europe and the USA since 2014 and 2015, respectively. Almost immediately, experts suggested taking the drug in tandem with sofosbuvir. As a result, we received a 98-100% cure without significant adverse reactions. For a long time, the regimen was the only treatment method, but despite the emergence of a new generation of drugs, sofosbuvir and daclatasvir still remain the most commonly used drugs for hepatitis C.

The time frame for obtaining approval for the use of sofosbuvir in the United States has become and continues to be the shortest in the history of the Food and Drug Administration (FDA). Within six months from the date of registration, 30,000 patients in the United States received treatment with sofosbuvir.

Manufacturers

The right to produce the original drug with the active ingredient sofosbuvir (trade name Sovaldi, Sovaldi) belongs to the American pharmaceutical company Gilead Sciences. In 2014, the patent holder announced that the license for the right to produce medicines based on sofosbuvir would be transferred to other corporations, but sales should be carried out only in developing countries (today this list includes 91 countries).

The manufacturer of the original drug based on daclatasvir (trade name Daklinza) adheres to a similar policy. This is the Bristol-Myers Squibb company, USA. Thus, sofosbuvir and daclatasvir are now produced by Indian and Egyptian pharmaceutical companies, and generics produced in Venezuela are also available.

All Sovaldi and Daklinza analogues available for order in Russia and most CIS countries are presented in the table. Preparations containing sofosbuvir with daclatasvir:

Generic name	Manufacturing company
Sofosbuvir
Sofokast + Dacikast	Aprazer, India
Hepcinat + Natdac	Natco Pharma (Natco company), India
Sovihep + Dacihep	Zydus Heptiza (Zydus), India
Resof + Hepcfix	Dr. Reddy's (Doctor Reddys), India
Virso + Qurdac	Strides Shasun (Strides), India
Sofovir + Daclahep	Hetero (Hetero), India
Lucifos + Lucidac	Lucius Pharmaceuticals (Lucius), India
Myhep + Mydecla	Mylan, India
Viropack + Daclavirocirl	Marcyrl Pharmaceuticals (Marcyrl), made in Egypt
Sofolanork + Daklanork	Mash Premiere (Mash Premier), Egypt
Gratisovir + Daktavira	Pharco Pharmaceuticals (Farco), Egypt
Augispov + Augidacla	Aug Pharma, Egypt

Which manufacturer is better

Given the variety of generics on the market, patients often wonder which manufacturer is better. Many doctors suggest choosing medications manufactured by Natco. It is the first pharmaceutical company to develop a fixed combination of sofosbuvir and daclatasvir (sold under the trade name Hepcinat Plus). But, on the other hand, drugs from Natco are almost one and a half times more expensive than other generics.

Many hepatologists, in response to the question of which manufacturer to choose, advise taking a course of Myhep and Mydekla. These drugs are produced by Mylan, part of which is owned by the American pharmaceutical corporation. Hetero's medicines disappeared from the market for a while because minor technological process violations were discovered, but the company's management promptly eliminated them.

It is difficult to name the best generic drug manufacturer. All Indian analogues are produced under the strict control of Gilad and Bristol-Myers Squibb.

Instructions for use

The instructions for use contain all the important information regarding how to take sofosbuvir and daclatasvir in combination therapy for hepatitis C. All indications for use are listed and treatment regimens are described. Additionally, data from clinical studies published in specialized medical journals and the WHO website are provided. The annotation also indicates how these tablets work against hepatitis C, and provides other features of antiviral therapy (AVT).

Release form

Available in tablet form.

Description and composition of the drug

Sofosbuvir is included in monopreparations in a dose of 400 mg. The same amount of the substance is contained in combination medications. As for Daclatasvir, generics are produced in only one dosage - 60 mg. But the original is additionally available with a mass fraction of the active component of 30 mg and 90 mg (a dose change is necessary if you take daclatasvir and some other drugs that affect its pharmacokinetics at the same time). The description of the drugs also includes a list of auxiliary ingredients.

Pharmacodynamics

Treatment with sofosbuvir and daclatasvir causes eradication (destruction) of the hepatitis C pathogen in almost 100% of cases. This effect is due to the principle of how the combination of drugs works.

Mechanism of action of drugs

Sofosbuvir, along with daclatasvir, have a similar effect on the processes of replication (reproduction) of the hepatitis C pathogen. Antiviral components directly affect non-structural proteins involved in both the division of the pathogen's RNA and the construction of new virions (RNA polymerases). The use of two drugs simultaneously provides a comprehensive effect on the virus.

Daclatasvir blocks the division of viral RNA, and sofosbuvir in the form of a metabolite breaks the chain of construction of the HCV genome.

Pharmacokinetics

The main pharmacokinetic characteristics of the combination of antiviral agents are shown in the table.

Sofosbuvir	Daclatasvir
Absorption
It takes approximately 2 hours to reach maximum concentrations of unchanged sofosbuvir. Bioavailability exceeds 90%	The maximum concentration is achieved on average in 1.5-2 hours. Bioavailability practically does not exceed 65%
Distribution
In unchanged form, it is 60-65% protein bound; the metabolite does not interact with serum proteins	Fully binds to plasma proteins
Biotransformation
It occurs in the liver. The compound formed acts in the body, stopping the replication of HCV	Carried out with the participation of liver enzymes
Elimination
Mainly excreted in urine, slightly excreted in feces and carbon dioxide from the lungs	Mainly excreted through the intestines, slightly through renal excretion
Pharmacological characteristics in certain categories of patients
Since sofosbuvir is excreted mainly through the kidneys, damage to the urinary system affects the pharmacological properties of the drug. Liver damage does not affect the pharmacokinetics of sofosbuvir	Severe kidney damage alters the pharmacokinetics of daclatasvir. Liver damage affects the pharmacological properties of the drug

Active ingredients

The international nonproprietary name of daclatasvir is Daclatasvir. Belongs to the group of inhibitors of the non-structural protein NS5A. The INN of sofosbuvir is sofosbuvir. According to pharmacological systematics, it is an inhibitor of the non-structural protein NS5B.

Indications for use

Sofosbuvir and daclatasvir are prescribed for the treatment of chronic hepatitis C. Indications for use include therapy of 1 genotype (subtypes a and b), as well as 2-4 types of pathology. Taking medications is allowed in cases of combined HCV and HIV.

note

Contraindications

The list of strict restrictions on taking medications includes:

• individual allergic reactions;
• severe kidney damage (pathology stage is determined by creatinine clearance);
• age up to 18 years.

The FDA has assigned sofosbuvir, like daclatasvir, a grade B risk in pregnancy. This means that the use of the drug in animals was not accompanied by an embryotoxic effect. But the effect on the development of the fetus and the woman’s body during pregnancy is unknown. Therefore, the list of contraindications also includes pregnancy and lactation.

Dosage and how to take

Medicines are taken 1 tablet once a day (with an interval of 23-26 hours, you can take it in the evening), regardless of meals. Dosage: 400 mg of sofosbuvir and 60 mg of daclatasvir. If drugs are taken that affect the bioavailability of daclatasvir, its dose is either increased to 90 mg or reduced to 30 mg.

Sometimes the treatment regimen is supplemented with ribavirin. The doctor tells you how to take all medications together. Ribavirin should be dosed correctly by weight, on average the daily amount of medication is from 0.8 to 1.2 g. This dose is divided into 2 doses - preferably in the morning and in the evening, with an interval of 12 hours.

Hepatitis C treatment plan

A correctly selected course of treatment guarantees almost 100% recovery. The hepatitis C treatment regimen proposed by WHO and FDA specialists is presented in the table.

Type of virus, liver condition, anamnesis and other features of the course of the disease	Rules and duration of taking sofosbuvir simultaneously with daclatasvir
1 genotype without cirrhosis or at the stage of compensated cirrhotic damage to the liver parenchyma	Daclatasvir + sofosbuvir for 12 weeks
1 genotype against the background of decompensated cirrhosis or after liver transplantation	Sofosbuvir + daclatasvir + ribavirin for 12 weeks
2 genotype	Sofosbuvir + daclatasvir for 12 weeks without cirrhosis. Concomitant decompensated cirrhosis can be cured by extending therapy to 16 or 24 weeks
Treatment of genotype 3 without cirrhosis	Sofosbuvir + daclatasvir for 12 weeks
Type 3 HCV due to cirrhosis, after liver transplantation	Sofosbuvir + Daklinza + ribavirin for 12 weeks

Important

Previously, the sofosbuvir + daclatasvir regimen was also used for the fourth genotype of HCV. But after frequent cases of treatment failure, current WHO recommendations provide for the use of fixed combinations of sofosbuvir with ledipasvir or velpatasvir.

Side effects

Side effects when using sofosbuvir together with daclatasvir are extremely rare. Many symptoms are reversible and disappear, if not on time, then soon after stopping taking the pills.

Patients are warned about the possibility of:

• headaches;
• dizziness;
• slight deterioration in health, weakness, asthenia.

Antiviral drugs that directly affect the pathogen have practically no effect on the stomach. Side effects are much more pronounced when taking ribavirin together.

In addition to these adverse reactions, consequences of antiviral therapy may include:

• psychoemotional disorders;
• insomnia;
• skin rash and itching.

The severity of adverse reactions depends not only on the treatment regimen, but also on associated factors. These are liver conditions (for example, A4 fibrosis or cirrhosis contribute to digestive disorders), co-infections, age, lifestyle, etc.

Compatibility with other drugs

There are a number of restrictions regarding the possibility of combining daclatasvir and sofosbuvir with medications. Some drugs (including certain antibiotics) negatively affect the pharmacological properties of antiviral agents.

Drug compatibility table with sofosbuvir and daclatasvir

Drugs	Features of interaction
Antiretroviral drugs	Sometimes a dose adjustment of daclatasvir is required
Antiarrhythmic drugs, Nifedipine	Prescribed with caution
Anticoagulants, including Aspirin	Prescribed under laboratory control
Anticonvulsants	Contraindicated
Products containing St. John's wort	Contraindicated
Drugs metabolized by CYP enzymes	Dose adjustment of daclatasvir is necessary
Statins	Admission is possible only under strict indications

Important

For questions about compatibility with other drugs, it is better to seek help from a doctor.

Alcohol compatibility

Many patients are interested in whether alcohol is allowed during treatment. But doctors warn that such interaction is contraindicated. The compatibility of these drugs and ethanol has not been studied, but alcohol is contraindicated for any liver damage.

Pregnancy and lactation

Safety and risk for fetal development have not been established. It has not been determined whether the active substances or their metabolites pass into breast milk. Therefore, the answer to the question whether it is possible to take medications while carrying a child or breastfeeding is negative.

Pregnancy after treatment

According to the results of experiments on rodents, the drugs do not affect conception and fertility. However, the issue of pregnancy after treatment must be discussed with a doctor.

special instructions

Patients with impaired renal function, decompensated cirrhosis, and cardiovascular disorders, especially those taking Amiodarone, require constant monitoring.

Important

Diet during the treatment of hepatitis C, regardless of the regimen, is mandatory.

How to monitor treatment

What tests should I take to evaluate the effectiveness of therapy? To determine how quickly taking the pills has an effect and whether the correct treatment regimen has been prescribed, PCR tests are prescribed at 4 and 12 weeks of using the medication. Ideally, the result of the first PCR should be negative; normally, it should decrease compared to the original one.

What is prohibited during treatment

During therapy, as well as for some time after its completion, the patient should:

• do not smoke (compatibility with marijuana is also not allowed);
• do not eat incompatible foods (fatty, fried, smoked, coffee, etc.);
• exclude alcohol;
• observe work and rest schedules;
• avoid the influence of stress factors.

The doctor will tell you in detail what diet is necessary when taking sofosbuvir and daclatasvir. Usually the patient is prescribed food according to table No. 5.

Overdose

To avoid overdose, you must strictly adhere to the dosage time prescribed by your doctor. The possibility of taking it if missed depends on the pharmacokinetics of the drugs. Ribavirin can be taken within the next 6 hours after the scheduled time, sofosbuvir, daclatasvir - within 10 hours. If the dose is exceeded, you must go to the hospital.

Storage conditions and shelf life

Tablets are stored at room temperature and discarded after the expiration date indicated on the package.

Discontinuation of therapy

All prescribed antiviral drugs are taken together and stopped after the course of therapy. But many patients have a question, what next? Recovery after treatment involves taking hepatoprotectors, following the principles of proper nutrition, giving up bad habits and playing sports.

Probability of relapse after treatment

Properly selected therapy reduces the risk of relapse after treatment to almost zero. But to exclude this possibility, the patient’s task is to regularly donate blood for PCR. Detection of the virus means that either therapy did not help, or re-infection occurred. According to clinical studies, the risk of relapse does not exceed 1-2%.

Non-structural analogues

There are no Russian drugs with direct antiviral action yet. Of the American analogues, sofosbuvir + daclatasvir regimens can offer:

• Epclusa;
• Harvoni;
• Maviret;
• Viqueiro Pak;
• Zepatir.

These analogues are registered in Russia, but there is a chance for treatment either under a quota for free therapy, or if there is financial opportunity. Indian generics can replace Epclusa and Harvoni. An abstract in Russian is attached only to medicines registered in the Russian Federation.

Benefits of the antiviral combination

This type of treatment regimen for hepatitis C is actively in demand, since the course of treatment rarely exceeds 12 weeks and has virtually no contraindications. Side effects when taken are rare. The rules of treatment are simple: it is enough to take 2 tablets per day (or one when using combined Indian drugs). Original medicines are completely replaceable with generics, for the production of which purified substances are used.

Cost and where to buy

The price of a course of treatment with original drugs is measured in tens of thousands of dollars. Thus, a package of Sovaldi (28 tablets) can be purchased in Moscow for 150,000-170,000 rubles (you will need at least 3 such boxes), Daklinza (also 28 tablets) for 55,000-60,000 rubles. The cost of generics including delivery is much lower.

On average, treatment with generics (a course of 12 weeks) costs $600-750 (it is profitable to purchase several packages at once).

The drug Sofosbuvir is the first drug for the treatment of chronic hepatitis C, which is radically different from its predecessors. It was with the advent of Sofosbuvir that viral hepatitis C was no longer considered an incurable disease, the treatment of which can only achieve long-term remission, but not complete recovery.

In 2013, the pharmaceutical company Gilead began producing the original drug, the main active ingredient of which is Sofosbuvir. This drug has been approved and approved for use by the FDA. Numerous clinical trials of Sofosbuvir have demonstrated:

• excellent performance (100% virological response in almost all patients);
• short duration of use (only 12 weeks of the full course versus 24 and 48 in the case of interferon therapy);
• high safety profile and good tolerability.

The Sofosbuvir treatment regimen has been included in all treatment protocols for chronic hepatitis C. Currently, Indian and Egyptian pharmaceutical companies produce generics - drugs with the same active ingredient, that is, Sofosbuvir, but at a much lower price. Reducing the cost of a course of antiviral therapy makes the possibility of a complete cure available to more people infected with HCV.

Composition and release form

Sofosbuvir is available only in tablet form containing 400 mg of active substance. It is characterized by high bioavailability - 92%, which ensures rapid penetration into all organs and tissues, including the liver. As a result of certain biochemical transformations, Sofosbuvir breaks down into active metabolites, which provide a stable and long-lasting antiviral effect.

The half-life of Sofosbuvir and its metabolites is 27 hours, that is, a tablet per day is enough to maintain the necessary antiviral effect.

The main active ingredient and its active metabolites are excreted mainly in feces (80%) and to a much lesser extent in urine. Thus, there is no need to adjust the dosage of Sofosbuvir in patients suffering from chronic renal pathology.

The original drug and its generic analogues contain only one dosage of Sofosbuvir - 400 mg. Only the number of tablets in the package differs: 28 or 30 pieces for generics, 28 tablets in a pack of the original Sovaldi, as well as the price of a specific brand. The composition of the drug does not change in different brands.

Given the excellent pharmacokinetic characteristics of Sofosbuvir, there is no need to create an injection form of the drug. The effectiveness of the standard dosage precludes the advisability of creating a larger dosage of this drug.

Storing the drug does not involve any difficulties: the bottle or cardboard box should be kept at room temperature, average air humidity and away from direct sunlight.

How the drug works

The mechanism of action of Sofosbuvir is to act on a certain enzyme - polymerase. This NS5B enzyme is responsible for the processes of formation of new viral particles and the assembly of new viral RNA from them. Since Sofosbuvir is an inhibitor of this enzyme, the above-described actions of the virus become impossible: new particles are not formed. Thus, the patient’s body is gradually cleared of the hepatitis C pathogen and the person recovers completely.

The effect of Sofosbuvir is assessed by quantitative and qualitative tests for detecting viral RNA in the patient’s blood. If, after completing the full course of antiviral treatment, RNA is not detected in the blood of a patient with chronic hepatitis C, then this is regarded as a complete virological response and is interpreted as recovery. Along with the virological, the biochemical is assessed - the normalization of intracellular liver enzymes. In addition, the patient himself feels an improvement in his own condition, as all the symptoms of the disease gradually disappear.

It is important to repeat biochemical and virological tests six months and a calendar year after completion of treatment.

Taking into account the peculiarities of the action of Sofosbuvir, its almost 100% effectiveness, the examination results do not change, which indicates a stable biochemical and virological response.

When is the drug prescribed?

Sofosbuvir is used as part of a combination treatment of chronic hepatitis C. Experts in the field of infectious hepatology emphasize that the use of Sofosbuvir as a monotherapy is inappropriate; it can only be used in combination with other drugs with a direct antiviral effect.

The indication for the use of Sofosbuvir is chronic viral hepatitis C (various genotypes).

Treatment with Sofosbuvir can be prescribed to any patient over 18 years of age, with newly diagnosed chronic hepatitis C, or after an unsuccessful episode of treatment with other drugs.

Common treatment regimens

How long you need to take Sofosbuvir, and which antiviral agents are best to combine it with, will be decided by your attending physician. Attempts at self-treatment can significantly harm the patient’s health. Even detailed instructions for use cannot reflect all the nuances of combination antiviral therapy and possible drug interactions.

Modern international protocols for the treatment of chronic hepatitis C recommend the use of Sofosbuvir 400 mg according to the following regimens:

patient category	other antiviral agents for complex therapy	duration of antiviral treatment
patients with identified HCV genotype 1a and 1b	+ IFN pegylated Ribavirin	12 weeks
	+ Simeprevir IFN pegylated Ribavirin	12–36 weeks
	+	12 weeks
	+ Ledipasvir	12 weeks
	+ Velpatasvir	12 weeks
patients with identified genotype 2 and 3 HCV	+ IFN pegylated Ribavirin	12 weeks
	+ Daclatasvir	12 weeks
	+Velpatasvir	12 weeks
patients with identified HCV genotype 4	+ IFN pegylated Ribavirin	12 weeks
	+ Ledipasvir	12 weeks
	+ Simeprevir	12 weeks
	+ Daclatasvir	12 weeks
	+Velpatasvir	12 weeks
patients with identified HCV genotype 5 or 6	+ IFN pegylated Ribavirin	12 weeks
	+ Ledipasvir	12 weeks
	+ Daclatasvir	12 weeks
	+ Velpatasvir	12 weeks
(any HCV genotype)	+ IFN pegylated Ribavirin	12 weeks
patients with compensated cirrhosis (HCV genotype 1 or 4)	+ Simeprevir	24 weeks
	+ Simeprevir Ribavirin	12 weeks

Patients awaiting liver transplantation receive antiviral therapy until surgery. Patients with compensated liver cirrhosis receive specific treatment according to the same regimens as other patients, that is, depending on the genotype of the hepatitis C virus. People with associated HCV and HIV infection can receive such treatment if the expected benefit outweighs the expected risk.

Contraindications

There are absolute and relative contraindications to the use of Sofosbuvir. Absolute situations are those that cannot change over time, and relative ones are those that undergo transformation accordingly.

The safety profile and clinical effectiveness of Sofosbuvir in patients with decompensated liver cirrhosis and severe chronic renal failure have not been studied, therefore its use is prohibited.

Use during pregnancy and childhood

Both categories of patients are absolute contraindications for the use of Sofosbuvir.

Pediatric patients (under 18 years of age) cannot be treated with this antiviral drug, since the effectiveness of the drug and the safety profile have not been studied.

The active substance Sofosbuvir has a pronounced embryotoxic and teratogenic side effect, therefore such antiviral therapy is strictly prohibited for patients at any stage of gestation. Even after completing a course of antiviral therapy, a woman must use reliable contraception for 6 months.

The same recommendations apply to a male patient whose sexual partner may become pregnant. Sofosbuvir penetrates into sperm and, during sexual intercourse, into the woman’s body. Where irreparable serious changes can occur.

Side effects

Reviews from patients indicate that Sofosbuvir is well tolerated. It is extremely rare that a dose adjustment of this drug is required, and cases of discontinuation of therapy due to poor tolerability are rare.

As already mentioned, Sofosbuvir is not used as monotherapy, but only in combination with other antiviral drugs. Therefore, it is more correct to assess the risk of possible side effects depending on the combination with other drugs; specific options are given in the instructions.

Extensive studies have been conducted in the United States and European countries on the tolerability of therapy with modern antiviral drugs. Most often, patients noted the following signs of changes in their own condition during treatment with Sofosbuvir:

Rare side effects associated with the use of Sofosbuvir include:

• mental disorders (suicide attempt);
• severe hematological disorders (up to pancytopenia);
• prolonged and severe bradycardia (during treatment with amiodarone).

Taking Sofosbuvir with certain other medicines can cause serious changes in the human body. Combination use has not always been studied in human volunteers, but assumptions are made based on a detailed description of the mechanism of action.

A detailed description of a possible decrease in effectiveness is given in the instructions for the drug; it is necessary for specialists in the appropriate medical profile. The patient only needs brief information that Sofosbuvir is not recommended to be combined with:

The patient must notify his doctor if he is taking anything from the above list before starting antiviral therapy.

Nutrition during treatment

Almost all patients with chronic hepatitis C know about the need to follow a diet. This is necessary in order to reduce the damaging effect on liver tissue to the minimum possible. The main damage is caused by the hepatitis C virus, and various toxic products, including alcohol, can increase this effect.

The details of the treated diet should be discussed with the attending physician: for one patient it is enough to adjust his lifestyle, while for another he will have to radically change his eating habits. Any patient needs to understand that it is absolutely forbidden to combine alcohol and antiviral drugs, as this can nullify all achieved treatment results.

The general principles of dietary nutrition for chronic hepatitis C are as follows:

• portions should be small;
• It is better to eat little by little, but often, than rarely and in large portions;
• all food should be at room temperature, not too hot and not too cold;
• Only such culinary processing options as stewing and boiling are allowed, fried foods are prohibited;
• Hot, smoked, spicy dishes should be excluded;
• You should give preference to cereals, seasonal vegetables and fruits, as well as low-fat dairy products.

After completing the course of antiviral therapy, the patient can return to a normal diet.

Cost and where to buy the drug

One of the main questions that arises for a patient with CHC is... To cure this infectious disease, it is important to carry out the full course of treatment; if it is interrupted ahead of schedule, the virus will appear in the blood again. Therefore, the issue of estimated cost is very important.

Currently, only the original drug Sovaldi is registered in the Russian Federation. This Sofosbuvir is very expensive: 55–65 thousand US dollars for the entire course. It can be bought in pharmacies across the country.

For patients with an average income, the way out of the situation is a generic drug made in India or Egypt. Their price starts from 150 US dollars for 1 bottle of the drug (1 month of therapy). The problem is that it is difficult to distinguish a medicine from a counterfeit, so the purchase must be made from.

Generics are not registered by the pharmaceutical committee, so you cannot buy them at a pharmacy. The purchase can be made on an online resource or from a medical representative. Before purchasing, it is advisable to look on the World Wide Web to see what tablets from a particular manufacturer look like and how to check its authenticity (special holograms, type of bottle, etc.).

List of Sofosbuvir analogues

Among the generics sold in the Russian Federation are the following:

The possibility of purchasing this or that medicine must be checked with your doctor. Analogues of Sofosbuvir in Russia can be bought in almost any major city.