Lindinet contraceptives are an effective monophasic contraceptive. Contraceptive pills Lindinet Lindinet 20 instructions for use reviews from women
Compound Lindinet 20(1 tablet):
- – 0.02 mg;
- – 0.075 mg;
- Magnesium stearate – 0.2 mg;
- povidone – 1.7 mg;
- corn starch – 15.5 mg;
Compound Lindinet 30(1 tablet):
- ethinyl estradiol – 0.03 mg;
- gestodene – 0.075 mg;
- sodium calcium edetate – 0.065 mg;
- Magnesium stearate – 0.2 mg;
- colloidal silicon dioxide – 0.275 mg;
- povidone – 1.7 mg;
- corn starch – 15.5 mg;
- lactose monohydrate – 37.165 mg.
Both pharmaceutical forms are supplied in the form of tablets, the shell of which has the following components:
- sucrose – 19.66 mg;
- – 8.231 mg;
- macrogol 6000 – 2.23 mg;
- titanium dioxide – 0.46465 mg;
- povidone – 0.171 mg;
- yellow quinoline dye (D+S yellow No. 10 – E 104) – 0.00135 mg.
Release form
In pharmacy kiosks, the drug is presented in the form of round, biconvex tablets, which are coated with a light yellow coating on both sides. There are no inscriptions or symbols. At the break, the tablet is white or close to white in color with a light yellow edging of the shell.
pharmachologic effect
Lindinet belongs to the group of monophasic combined oral medications based on sex hormones , accordingly, is used primarily for the purpose of contraception. The main therapeutic effect of the drug is associated with several mechanisms of action, including a decrease in the secretion of gonadotropic hormones , actively preventing ovulatory processes and inhibiting the maturation of follicles in the ovaries.
First of all, it should be noted that ethinylestradiol , one of the biologically active components, is a synthetic analogue of follicular hormone , which, together with the hormones of the corpus luteum, is involved in the regulation menstrual cycle women, significantly slowing it down at certain stages.
Another active ingredient is gestodene is a progestogen 19-nortestosterone derivative and is a stronger and more selective version of natural secreted by the corpus luteum. This component is used in ultra-low quantities, due to which it does not realize its androgenic potential (the chemical basis for gestodene is a variation of the male sex hormone) and has the weakest effect on the carbohydrate and lipid metabolism of the body.
In addition to the central mechanisms of action directly on sex hormones, the drug exerts contraceptive properties indirectly through peripheral components. Under the influence of a pharmaceutical drug, susceptibility decreases to the blastocyst, which makes the process of implantation of the initial forms of the fetus almost impossible. The density and viscosity of the mucus localized in the cervix also increases, which becomes largely impenetrable for sperm making active movements towards the female egg.
Lindinet not only has contraceptive effects, the pharmaceutical drug promotes active prevention some gynecological diseases and more. In particular, the possibility of the appearance of functional ovarian cysts And . Reduces the risk of occurrence in the mammary glands, congestive inflammatory processes practically disappear. Favorable properties medicine also apply to skin , since their general condition improves and the degree of manifestation decreases (with regular use, dermatological defects disappear completely).
Pharmacodynamics and pharmacokinetics
Pharmacokinetic properties of gestodene
After oral administration, the active component is absorbed quite quickly and almost completely from gastrointestinal tract, because its bioavailability is about 99%, and the maximum concentration of 2-4 ng/ml is observed after 1 hour.
In the bloodstream gestodene contacts And specific globulin SHBG , only 1-2% of the amount of the active ingredient remains in free form. The pharmacokinetics of gestodene largely depends on the level of SHBG and the concentration of estradiol, because the amount of the selective transporter increases 3 times under the influence of the sex hormone. Constant use of oral contraceptives also contributes to the active saturation of gestodene; with daily use, the concentration increases by 3-4 times.
The active component undergoes the main stages of biochemical transformation in the liver, after which only in the form of metabolites is excreted in the urine (60%) and feces (40%). The half-life of the active component is biphasic and takes about 1 day, since the average plasma clearance ranges from 0.8 to 1 ml/million/kg.
Pharmacokinetic properties of ethinyl estradiol
The second active component has slightly lower absorption rates - due to presystemic conjugation and primary metabolism, the absolute bioavailability of the pharmacological component from the digestive tube is only 60%, and the maximum concentration of 30-80 pg/ml is achieved after 1-2 hours.
On the distribution side, ethinyl estradiol, on the contrary, outperforms gestodene, because 98.5% of the active substance binds to nonspecific albumin. Also, the active component induces an increase in SHBG levels, which has a beneficial effect on the overall effectiveness of the oral contraceptive. A constant average level of ethinyl estradiol is established by 3-4 days after the start of the therapeutic course, and it is 20% higher than after a single dose of Lindinet tablet.
Biotransformation of the active substance occurs in the liver and is aromatic hydroxylation with the formation of methylated and hydroxylated metabolic products in free form or in the form of conjugates with sulfates or glucuronides. Metabolic clearance from blood plasma ranges from 5-13 ml.
Ethinyl estradiol is excreted only in the form of metabolic products with urine and bile in a ratio of 2:3. The half-life, like that of gestodene, is biphasic and is about 1 day.
Indications for use
- contraception;
- functional disorders of the menstrual cycle.
Contraindications
- individual hypersensitivity to the pharmaceutical drug or its components;
- risk factors for arterial or venous thrombosis;
- moderate to severe;
- transient ischemic attack or as a harbinger of thrombosis;
- surgery with prolonged immobilization;
- with a pronounced increase in blood triglycerides;
- dyslipidemia ;
- severe liver disease ( hepatitis , cholestatic jaundice and etc);
- Gilbert, Dubin-Johnson, Rotor syndrome;
- neoplasm localized in the liver;
- otosclerosis or a history of it in a previous pregnancy or after taking glucocorticosteroids;
- smoking over the age of 35;
- hormone-dependent malignant tumors genitals and mammary glands;
- vaginal bleeding of unknown origin;
- period of lactation and childbearing.
Side effects
Adverse effects of treatment requiring immediate cancellation pharmaceutical therapy:
- From the outside of cardio-vascular system: arterial hypertension, , , deep vein thrombosis of the lower extremities, , venous or arterial thromboembolism hepatic, mesenteric, retinal or renal vessels.
- From the outside sense organs: hearing loss caused by otosclerosis .
- Other: porphyria , hemolytic-uremic syndrome, exacerbation of reactive , Sydenham's chorea .
Side effects, after the appearance of which the advisability of further use of the drug is decided in individual order:
- From the outside reproductive system: acyclic bleeding from the vagina of unknown etiology, , colpocytological change in vaginal mucus, inflammatory diseases, , pain, breast enlargement, galactorrhea .
- From the outside central nervous system: hearing loss, , , mood lability.
- Dermatological reactions: or exudative erythema , unclear rash, chloasma, increased .
- From the outside digestive system : epigastric pain, nausea and vomiting, Crohn's disease , nonspecific ulcerative , jaundice and the itching that is caused by it, cholelithiasis , liver adenoma, hepatitis.
- From the outside metabolic processes: fluid retention in the body, decreased tolerance to carbohydrates, increased levels of triglycerides or blood glucose, weight gain.
- Other allergic reactions.
Instructions for use of Lindinet (Method and dosage)
Lindinet 20, instructions for use
Birth control pills are used orally once a day, without chewing and with a sufficient amount of water, regardless of meals. If possible, you should take the pills at the same time of day for 21 days, then take a break for 7 days, and then resume using contraceptives. That is, the next tablet should be used 4 weeks from the start of the course on the same day of the week. During the break there will be observed uterine bleeding, which corresponds to menstruation in a normal cycle.
A course of conservative contraception should be started from the 1st to the 5th day of the menstrual cycle, if other oral contraceptives have not been used before. Otherwise, the 1st tablet must be taken after taking the last dose of the previous pharmaceutical preparation containing hormones, on the 1st day of bleeding after discontinuation.
Transition from progestogen-containing agents Lindinet requires the use of an additional method of contraception in the first week. The date of first use of a new contraceptive should be consistent with the pharmaceutical form of the previous drug:
- in the form of mini-tablets - on any day of the menstrual cycle;
- in case of injections - on the eve of the last injection;
- implant - the day after its removal.
Lindinet 30, instructions for use
Since this pharmaceutical form is an enhanced version of Lindinet 20 with a higher concentration of ethinyl estradiol, it is recommended to be prescribed after abortion , so that the restoration of physiological hormonal levels occurs much faster and less painfully.
If the abortion was performed in 1st trimester of pregnancy , then there is nothing to worry about. Taking oral contraceptives can be started immediately after gynecological manipulation and there is no need to use additional methods of contraception.
If the abortion or childbirth occurred during 2nd trimester of pregnancy , then taking the pharmaceutical drug can be started only on the 21-28th day after the obstetric surgery. If the course of conservative protection is started later, a barrier method of contraception should be used in the first week. If full sexual intercourse took place before starting to take the drug, then before taking birth control you need to make sure that there is no new pregnancy.
Skipping an oral contraceptive pill
If the next dose of the tablet was missed, then the missing amount of the pharmaceutical drug in the bloodstream must be replenished as quickly as possible. With a delay that duration does not exceed 12 hours , the clinical effects of the contraceptive are not reduced and the need for additional protection by other methods of contraception automatically disappears. Subsequent tablets are taken according to the usual regimen.
If a woman misses a pill and did not make up for her loss within 12 hours , then the pharmacological effectiveness of the drug is reduced, which requires special measures and precautions. First of all, you should resume taking the drug as soon as possible and continue to take it as usual. It is recommended to use any other methods of contraception for a week after the missed period.
This situation may become more complicated if There are less than 7 tablets left in the package . How to take it in this case - start the next pack without observing the required one-week break, which is carried out only after the end of the 2nd pack of contraceptives. It should be noted that while using the 2nd pack, spotting or even breakthrough bleeding may be observed, which can indirectly indicate the presence of pregnancy. If hemorrhages have not stopped after the end of the 2nd pack, then before continuing to take birth control you should consult a doctor and rule out the presence of a developing fetus in the womb.
Overdose
Taking an excess amount of contraceptive is accompanied by the following symptoms:
- nausea;
- vomit;
- vaginal bleeding in small quantities.
Specific pharmaceutical antidote for medicinal product no, therefore symptomatic therapy of individual clinical manifestations of intoxication is used.
Interaction
The contraceptive properties of a pharmaceutical drug are reduced when used with drugs such as , , , barbiturates, Primidon , , Phenylbutazone , Phenytoin , , Oxcarbazepine .
Therefore, if it is necessary to use these drugs together with Lindinet, it is necessary to use additional non-hormonal contraceptives for 7 days (it is recommended to visit an additional consultation with your doctor and clarify the period for certain). It is also possible to experience spotting or breakthrough bleeding, menstrual irregularities, or some other side effects.
In conditions increased peristalsis or diarrhea the residence time of the contraceptive drug in the lumen of the gastrointestinal tract is reduced, which significantly reduces the absorption properties of the hormonal contraceptive. Any drug that shortens the stay of Lindinet in the digestive tube leads to a decrease in the concentration of active components in the blood, and accordingly to a decrease in their beneficial effect.
Drug interactions at the suction stage are modeled on the combined use of a contraceptive with, since biologically active substances are equally subject to sulfation in the intestinal wall, which inhibits metabolic chains and increases the bioavailability of ethinyl estradiol.
Terms of sale
The purchase of medicines is permitted only using a prescription form.
Storage conditions
The pharmaceutical product must be stored in a dry place, protected from direct sunlight, inaccessible to young children at a temperature not exceeding 25 degrees Celsius.
Best before date
special instructions
Pregnancy after using hormonal contraceptives
Oral hormonal contraception is a group of pharmaceuticals based on synthetic analogues of female sex hormones (estrogen and progesterone), which prevent the onset of ovulation, preventing the very possibility of fertilization. Of course, a large audience of women is convinced that using them for contraception is harmful, since a normal, physiological pregnancy will most likely not occur after drug changes in hormonal levels. However, this is one of the myths about this group of drugs.
After stopping taking hormonal contraceptives and completing a course of conservative contraception, the effects of the drugs gradually disappear. The only peculiarity is that when planning pregnancy You should find out the exact timing of the optimal moment for fertilization in the antenatal clinic or from your personal gynecologist. After all, every time a woman takes a pill for a headache, she does not worry about the health of her unconceived child; in this case, the situation is almost identical.
When can you not use barrier methods of contraception?
Lindinet is a reliable hormonal contraceptive drug, which can be determined from a special indicator of the number of pregnancies that occurred during a course of oral contraception in 100 women for 1 year. For this pharmaceutical product, it is only 0.05, if you use the contraceptive correctly and only according to the application plan. However, the pharmacological effects of Lindinet do not fully develop immediately, but only by the 14th day from the start of taking the tablets, because in the first 2 weeks It is recommended to use barrier methods of contraception.
Lindinet 20 and Lindinet 30 - what's the difference?
A large number of visitors to pharmaceutical forums for women ask the following series of questions: “Lindynet 20 and 30 - what is the difference?”, as well as whether the drugs are interchangeable and, finally, which is better of the two forms of the contraceptive drug. The difference in forms of the same contraceptive lies in concentrations one of the active components is ethinyl estradiol. In oral tablets, the level can be 0.02 mg and 0.03 mg, respectively, which in biochemical terms does place them in different categories.
Lindinet 20 has a softer pharmacological effect and to a lesser extent helps to increase the selective transporter of SHBG, which makes it possible to use it for contraception, however for therapeutic needs , as a rule, a stronger form of the drug is required, which is why Lindinet 30 is used. How the more concentrated form of the drug differs from weaker tablets is not advertised, since sometimes for individual indications it is necessary to use Lindinet 30 even as a contraceptive, which may be perceived by the woman as an unfair burden with a hormonal drug.
It is strictly contraindicated to replace pharmaceutical forms of a drug on your own, because a qualified specialist who prescribes contraceptives or therapeutic agents relies on the results clinical trials, their interpretation and many years of experience in their field, and not on an approximate idea of the biomechanism female body. If any side effects or other adverse effects occur, you should seek advice and resolve the issue on an individual basis.
Since Lindinet is produced in Hungary, its cost in pharmacy kiosks is much lower than that of the drug produced jointly by French and German pharmacists, but this in no way indicates the effectiveness of the former, therefore the choice of a contraceptive should be entrusted to a qualified specialist, because he based on individual performance hormonal balance and some other medical aspects.
Which is better: Novinet or Lindinet 20?
Novinet – monophasic oral contraceptive, which, in addition to ethinyl estradiol, contains a synthetic progestogen , which somewhat changes the mechanism of action of the contraceptive drug. Like all artificial pharmaceutical components of this nature, desogestrel has a high affinity for progesterone receptors located in the hypothalamic-pituitary region, on which its effects are based. In sufficiently small quantities, it is able to “turn on” the negative feedback mechanism, which results in a sharp inhibition of the release and production of gonadotropins and a complete blocking of ovulation.
Since Novinet includes such a potent pharmaceutical component as one of the active ingredients, its price is accordingly almost twice as high as that of Lindinet. However, with certain individual indications or contraindications, a woman does not have the opportunity to use a cheaper contraceptive, which makes it possible to include Novinet in a conservative course of contraception.
Alcohol and Lindinet
Biochemical studies have proven that small amounts of alcohol do not affect the effectiveness of oral contraception. Moderate dosages of alcoholic beverages are considered to be up to 3 glasses of wine or 50 grams of cognac, but no more, since an increase in the amount of alcohol in the blood increases the risk of possible pregnancy.
Latin name: Lindynette
ATX code: G03AA10
Active substance: Ethinyl estradiol
Manufacturer: Gedeon Richter, Hungary
Conditions for dispensing from a pharmacy: On prescription
Lindinet 20 is one of the low-hormone oral contraceptives.
Indications for use
Lindinet 20 tablets are taken for contraceptive purposes, as well as to regulate impaired menstrual function.
Compound
One hormonal contraceptive tablet contains two main components, which are ethinyl estradiol and gestodene, their mass fraction is 0.02 mg and 0.075 mg, respectively.
Additionally there are the following substances:
- Povidone
- Magnesium stearate
- Corn starch
- Silicon dioxide in colloidal form
- Lactose monohydrate
- Sodium calcium edetate.
Medicinal properties
A contraceptive based on ethinyl estradiol and gestodene inhibits the process of synthesis of gonadotropic hormones by the pituitary gland, which helps slow down the maturation of follicles.
The estrogen component of birth control pills is represented by ethinyl estadiol, which is one of the synthetic analogues produced in human body the hormone estradiol, which is actively involved in the regulation of menstrual function together with progesterone.
Gestodene is the second component of the contraceptive; it is classified as a derivative of 19-nortestosterone; in terms of its potency, it is significantly superior to both the natural hormone, progesterone, and its synthetic analogue, levonorgestrel. Due to the fact that the activity of this gestagenic component of Lindinet is quite high, it is used in low doses. Due to this, there is no significant effect on the metabolism of fats and carbohydrates, and its androgenic properties do not appear.
The action of the contraceptive is associated with the work of both central and peripheral mechanisms that inhibit the process of follicle maturation, thereby reducing the susceptibility of the endometrial uterine layer to the blastocyst itself. At the same time, the viscosity of the discharge (namely cervical mucus) increases, which significantly reduces the likelihood of conception.
If you drink Lindinet 20 constantly (as the description for the drug indicates), you can observe the therapeutic effect of the contraceptive - the circulatory cycle is normalized, and the risk of developing certain gynecological ailments, including cancer, is reduced.
Ethinyl estradiol is almost completely absorbed by the mucous membranes of the gastrointestinal tract. 1-2 after taking the tablets (according to the instructions), its highest concentration in the blood is observed. The bioavailability rate is 60%. Communication with albumin is 98.5%.
As a result of aromatic hydroxylation, the formation of methylated and hydroxylated metabolites occurs. The elimination process takes place with the participation of the renal system and intestines, the half-life is 24 hours. In this case, a stable level of ethinyl estradiol is recorded on days 3-4.
Gestodene also quickly undergoes the process of absorption in the gastrointestinal tract, highest scores of this substance in the blood is reached after 60 minutes. The bioavailability of the gestagenic component of the drug reaches 99%.
The amount of gestodene in the blood decreases slowly, the half-life of metabolic products is 24 hours. A stable level of gestodene is observed in the 2nd half of the MC.
Release form
Hormonal pills are round, light cream in color, placed in blister packs of 21 pcs. There may be 1 or 3 blisters inside the pack. packaging with instructions.
Lindinet 20: instructions for use
Price from 381 to 2059 rubles.
The use of the hormonal drug Lindenet should be done every day at the same time to ensure their contraceptive effect. It is worth noting that Lindinet 30 is also accepted, the instructions for use are similar.
If a hormonal drug is used for the first time, then the first tablet is taken from 1 MC to 5 MC. It is necessary to take Lindinet 20 for 21 days, after which a seven-day withdrawal of the hormonal drug is provided, it is on these days that menstruation begins. Taking hormones from a new blister pack starts at 8 days. regardless of whether the withdrawal bleeding has completed or not.
Switching from another COC
The Lindinet 20 tablet will need to be taken the next day after the woman took the last COC pill from the blister. The beginning of the first menstruation proceeds as usual.
Switching from mini-pills, hormonal injectables, intrauterine systems, or implants
Hormone therapy can be started on any day of the MC if you have taken the mini-pill. When using earlier implants - on the day of removal, injection of hormones - on the day of the intended injection.
In case of switching from single drugs, it will be necessary to use barrier contraceptive measures so that the woman does not become pregnant during the first cycle of use.
After an early abortion (1st trimester)
Hormonal therapy with birth control pills should begin on the same day of surgery. Let the woman drink them according to the standard regimen; there is no need to use protection, since in this case you will not get pregnant. After an abortion, long-term hormone therapy is indicated.
After an abortion in later stages (2nd trimester)
The first Lindinet 20 tablet should be taken after 28 days. (one month) without using any additional contraceptive measures. If you take the contraceptive drug later than the specified period, for 7 days. You should additionally protect yourself from pregnancy.
If, before taking contraceptives, a woman had unprotected sexual intercourse, she should start using hormonal pills after ruling out possible pregnancy, or do something different - take the Lindinet 20 pill for the first time directly on the first day of the MC (when her own menstrual cycle begins).
Regimen for skipping pills
If you missed taking the tablets, there is no need to stop taking them; take the missed Lindinet 20 tablet as soon as you remember.
If gaps in taking pills do not exceed 12 hours, then the contraceptive effect works, barrier protection measures are not used. All subsequent tablets are taken as usual; skipping the drug does not affect the contraceptive effect.
If a woman happens to miss another dose of contraception, and the time interval exceeds 12 hours, hormonal pills are not as effective. The woman must take the pill she missed; subsequent ones are taken according to the standard regimen. Additionally, barrier methods of protection are used for 7 days. from the moment when there was a pass.
If a pill was missed and there are less than 7 pills left in the package, it is best that the woman does not take a break from taking hormonal pills. Skipping pills during the third week of contraceptive therapy does not significantly reduce its effectiveness.
It is worth considering that if you take these contraceptives continuously, you will not have periods, but breakthrough vaginal bleeding may occur while using tablets from a new blister. If after two months of continuous use of pills (including a cycle when there was a skip) menstrual-like bleeding does not occur, you should definitely rule out pregnancy while taking Lindinet 20. What to do next, consult a gynecologist, he will offer several options for solving the problem.
What to do if vomiting or diarrhea starts
If you experience vomiting or diarrhea while taking pills, and more than 3-4 hours have passed since taking the drug, this can be compared to skipping a pill, and the likelihood of pregnancy increases. What to do - take the same measures as in the case of a missed pill. If a woman does not want to change her contraceptive regimen, take Lindinet 20 tablet from a new blister.
How to postpone your period
If, with long-term use of a hormonal drug, there is a need to delay menstruation, take hormonal pills without the usual seven-day break. You can delay menstruation for any number of days, up to the end of the pills from the second blister. You should not exclude the possibility of spotting or breakthrough bleeding (this reaction of the body is considered normal). After the end of the seven-day break, you can drink Lindinet 20 as usual. What to do if you need to stop taking Lindinet, consult your gynecologist.
Use during pregnancy and pregnancy
Hormonal pills are not prescribed during pregnancy. If there is a need to use a contraceptive during lactation, you should stop breastfeeding.
Contraindications
You should not take this hormonal drug if:
- Excessive sensitivity to the components of the contraceptive
- Pathologies caused by impaired liver function
- Pathological neoplasms in the liver
- Tendency to thrombus formation, as well as thromboembolism
- Serious pathologies of the cardiovascular system (including myocardial infarction)
- Sickle cell anemia
- Presence of estrogen-dependent neoplasms
- Uterine bleeding of unknown origin
- Diabetes mellitus, which occurs against the background of microangiopathy
- Idiopathic jaundice
- Manifestations of herpes
- Pregnancy
- Otosclerotic changes
- Over 35 years of age (as the likelihood of developing side effects increases significantly with age).
Precautionary measures
Particular caution should be exercised in the presence of such pathological conditions and diseases:
- Severe migraine-like headaches
- Oncological process in the mammary glands
- Frequent epileptic seizures
- Pathologies of the functioning of the gallbladder (including cholelithiasis)
- Increased blood pressure
- Immobilization
- Depressive state
- Recovery period after major surgery
- Diabetes
- Cholestatic jaundice
- Various forms of liver failure.
If the patient is over 35 years old and smokes, it is worth consulting with a specialist about the possibility of switching to Lindinet 30. It is worth noting that the woman’s age and the amount of hormones taken directly affects the contraceptive effect. After 40 years, it is worth choosing other means of contraception.
Cross-drug interactions
In accordance with the instructions for Lindient 20 and 30 inducers of liver microsomal enzymes, antibacterial drugs significantly reduce the level of estrogen in the blood, which increases the likelihood of pregnancy. Is it possible to get pregnant during this period? Yes, the probability is quite high. During the entire treatment period and over the next 7 days. upon its cessation, it is necessary to resort to the use of additional contraceptive measures.
Liver enzyme inhibitors, in turn, help increase the concentration of estrogen components in the blood.
Drugs that increase gastrointestinal motility reduce the absorption of components of hormonal pills.
Ascorbic acid slows down the process of sulfation of estrogen components and increases their bioavailability.
The hormonal agent affects the metabolic processes of cyclosporine and theophylline in the body, which can cause an unexpected reaction from various organs and systems.
You should not drink preparations with St. John's wort, as heavy menstruation (bleeding) may begin during herbal treatment.
Patients with diabetes mellitus should adjust the dosage of hypoglycemic drugs taken.
It is worth noting that the same cross-interactions occur if Lindinet 30 birth control pills are taken.
Side effects
While taking birth control pills, unwanted reactions may develop:
- CVS: very rarely, thromboembolism or thrombosis may develop against the background of increased blood clotting, a sharp increase in blood pressure
- Gastrointestinal tract: severe nausea and vomiting, development of hepatocellular adenoma, possible hepatitis
- Reproductive system: decreased libido, heavy periods, impaired secretion of vaginal discharge
- Endocrine system: weight change, feeling of tightness in the chest
- CNS: emotional instability, tendency to depressive states (against the background of long-term hormonal therapy), frequent headaches, lethargy, increased fatigue, migraine (very severe headache).
You may also experience: painful sensations in the lower abdomen, the occurrence of chloasma (if you are prone to it, you should avoid prolonged exposure to the sun), intolerance to contact lenses, swelling, manifestations of allergies, symptoms of impaired glucose tolerance. This reaction can develop as a result of long-term use of hormones.
Overdose
If a woman has taken increased dosages of the drug, the following symptoms may be observed: nausea and vomiting, headache. An overdose may result in heavy periods.
Symptomatic therapy is recommended. What to do - consult a doctor (he will advise you to discontinue the drug) and take the prescribed medications. After this, there is a significant improvement in the general condition and cessation of bleeding. It is worth noting that there is no specific antidote.
Storage conditions and shelf life
Hormonal pills are stored at an average temperature not exceeding 30 C. The shelf life of the contraceptive is 3 years.
Analogues
Bayer Pharma, Germany
Price from 500 to 2142 rub.
Logest is similar in composition to Lindinet 20 and is a low-dose contraceptive. It is taken in the same way, it has similar contraindications, and can cause side effects similar to Lindinet. A pack contains 1 (21 tablets) or 3 (63 tablets) blister sheets. packaging.
Pros:
- The pills work effectively (block the onset of ovulation)
- Regulates MC
- Used to treat some hormone-dependent gynecological diseases.
Minuses:
- High price
- High risk of side effects
- Not prescribed if the woman is over 35 years old.
- active ingredients: gestodene, ethinyl estradiol;
- excipients: sodium calcium edetate, colloidal silicon dioxide, magnesium stearate, corn starch, povidone, lactose monohydrate.
Contraceptive pills Lindinet: instructions
Take one tablet orally once a day at a specified time for 21 days. After a week's break (withdrawal bleeding occurs) in taking the pills, contraception can be continued. The first Lindinet tablet should be taken on days 1-5 of the menstrual cycle. If you miss a scheduled pill, you should take it as quickly as possible.
Lindinet-20 and Lindinet-30
Lindinet-20 (microdized) and Lindinet-30 (low-dose) differ in the amount of the ethyl estradiol component; the dosage of gestodene (75 mcg) in both drugs is the same.
Indications for use:
- hormonal contraception;
- treatment of dishormonal disorders, uterine bleeding, anovulatory menstrual cycles;
- correction and prevention of hyperplastic processes in the reproductive organs.
Contraindications:
- individual intolerance to the components of the drug;
- history of arterial/venous thrombosis;
- atrial fibrillation, coronary artery/cerebral vascular disease;
- severe uncontrolled arterial hypertension;
- migraine, stroke, myocardial infarction;
- family history of venous thromboembolism;
- prolonged immobilization, diabetes mellitus with signs of angiopathy;
- cholestatic jaundice, pancreatitis, dyslipidemia;
- liver disease, cholelithiasis;
- otosclerosis, hormone-dependent tumor neoplasms of the mammary glands/genital organs;
- vaginal bleeding of unknown etiology;
- lactation, pregnancy.
Risk factors:
- age over 35-40 years, thrombosis, smoking;
- hemolytic uremic syndrome, obesity;
- severe trauma, thrombophlebitis, repeated depressive episode;
- ulcerative colitis, Crohn's disease, systemic lupus erythematosus.
Oral contraceptives Lindinet: side effects
- porphyria, horse racing blood pressure, short-term hearing loss;
- hemolytic-uremic syndrome;
- thrombosis of the veins of the lower extremities, Sydenham's chorea;
- acyclic bleeding, amenorrhea as a result of drug withdrawal;
- candidiasis, changes in libido;
- galactorrhea, pain in the mammary glands;
- diarrhea, lower abdominal pain, nausea;
- drug-induced hepatitis, ulcerative colitis, cholelithiasis;
- hair loss, erythema, rash;
- depressive episodes, migraines, headaches, dizziness;
- changes in body weight, fluid retention, decreased sensitivity to carbohydrates;
- allergic reactions.
Overdose:
No serious cases of overdose have been recorded; vomiting, nausea, and mild vaginal bleeding are possible. There is no specific antidote; symptomatic therapy is indicated.
Contraceptive Lindinet: reviews and drugs similar in action
Lindinet is one of the best modern oral contraceptives; more than 50% of women in need of contraception prefer Lindinet. The drug reliably prevents conception, regulates the menstrual cycle, and several times reduces the risk of malignant tumors of the endometrium and ovaries. Contraceptives similar in action: , .
Positive reviews:
- reduces the frequency of functional uterine bleeding;
- reduces the risk of mastopathy formation;
- provides a minimum of hormonal load on the body;
- does not cause complications, is easily tolerated;
- softens the manifestations of premenstrual syndrome, regenerates the endometrium.
Negative feedback:
- does not protect against HIV infection and sexually transmitted diseases.
Lindinet: reviews from doctors
Experts note the high contraceptive reliability of the drug Lindinet 20/30 (Pearl index 0.05). The use of Lindinet birth control pills prevents unplanned pregnancy, corrects the menstrual cycle, and restores the balance of sex hormones. The drug has a minimum of adverse reactions/complications and a number of protective/therapeutic properties. Recommended by gynecologists as a reliable oral contraceptive for all categories of women, including those with medical conditions.
Last update of the description by the manufacturer 07/13/2015
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Active substance:
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Compound
| Film-coated tablets | 1 table |
| active substances: | |
| ethinylestradiol | 0.02 mg |
| gestodene | 0.075 mg |
| Excipients | |
| core: sodium calcium edetate - 0.065 mg; magnesium stearate - 0.2 mg; colloidal silicon dioxide - 0.275 mg; povidone - 1.7 mg; corn starch - 15.5 mg; lactose monohydrate - 37.165 mg | |
| shell: quinoline yellow dye (D+S yellow No. 10 - E104) - 0.00135 mg; povidone - 0.171 mg; titanium dioxide - 0.46465 mg; macrogol 6000 - 2.23 mg; talc - 4.242 mg; calcium carbonate - 8.231 mg; sucrose - 19.66 mg |
Description of the dosage form
Pills: round, biconvex, covered with a light yellow shell, both sides without inscription.
At the break: white or almost white, with a light yellow edging.
pharmachologic effect
pharmachologic effect- estrogen-gestagenic, contraceptive.Pharmacodynamics
A combined agent, the effect of which is determined by the effects of the components included in its composition. Inhibits the pituitary secretion of gonadotropic hormones. The contraceptive effect of the drug is associated with several mechanisms. The estrogenic component of the drug is a highly effective oral drug - ethinyl estradiol (a synthetic analogue of estradiol, which participates together with the corpus luteum hormone in the regulation of the menstrual cycle). The gestagenic component is a derivative of 19-nortestosterone - gestodene, which is superior in strength and selectivity to not only the natural hormone of the corpus luteum progesterone, but also modern synthetic gestagens (levonorgestrel). Due to its high activity, gestodene is used in very low dosages, in which it does not exhibit androgenic properties and has virtually no effect on lipid and carbohydrate metabolism.
Along with the indicated central and peripheral mechanisms that prevent the maturation of an egg capable of fertilization, the contraceptive effect is due to a decrease in the susceptibility of the endometrium to the blastocyst, as well as an increase in the viscosity of the mucus located in the cervix, which makes it relatively impenetrable for sperm. In addition to the contraceptive effect, the drug, when taken regularly, also has a therapeutic effect, normalizing the menstrual cycle and helping to prevent the development of a number of gynecological diseases, incl. tumor nature.
Pharmacokinetics
Gestodene
Suction. When taken orally, it is quickly and completely absorbed. After taking one dose, Cmax in plasma is measured after an hour and is 2-4 ng/ml. Bioavailability is about 99%.
Distribution. It binds with albumin and sex hormone binding globulin (SHBG). 1-2% are in a free state, 50-75% are specifically bound to SHBG. The increase in SHBG levels caused by ethinyl estradiol affects the level of gestodene, leading to an increase in the SHBG-bound fraction and a decrease in the albumin-bound fraction. V d of gestodene - 0.7-1.4 l/kg.
Metabolism. Corresponds to steroid metabolism. Average plasma clearance is 0.8-1 ml/min/kg.
Excretion. The blood level decreases in two stages. The half-life in the final phase is 12-20 hours. It is excreted exclusively in the form of metabolites - 60% in urine, 40% in feces. T1/2 metabolites - approximately 1 day.
Stable concentration. The pharmacokinetics of gestodene largely depends on the level of SHBG. Under the influence of ethinyl estradiol, the concentration of SHBG in the blood increases 3 times; with daily use of the drug, the level of gestodene in plasma increases 3-4 times and in the second half of the cycle reaches a state of saturation.
Ethinyl estradiol
Suction. When taken orally, it is absorbed quickly and almost completely. Cmax in the blood is measured after 1-2 hours and is 30-80 pg/ml. Absolute bioavailability » 60% (due to presystemic conjugation and primary metabolism in the liver).
Distribution. Easily enters into a nonspecific relationship with blood albumin (about 98.5%) and causes an increase in SHBG levels. Average V d - 5-18 l/kg.
Metabolism. It is carried out mainly due to aromatic hydroxylation with the formation of large quantities of hydroxylated and methylated metabolites, partly in free, partly in conjugated form (glucuronides and sulfates). Plasma clearance » 5-13 ml/min/kg.
Excretion. Serum concentration decreases in 2 stages. T1/2 in the second phase » 16-24 hours. Excreted exclusively in the form of metabolites in a ratio of 2:3 with urine and bile. T 1/2 metabolites » 1 day.
Stable concentration. It is established by the 3-4th day, while the level of ethinyl estradiol is 20% higher than after taking a single dose.
Indications for the drug Lindinet 20
Contraception.
Contraindications
individual hypersensitivity to the drug or its components;
the presence of severe or multiple risk factors for venous or arterial thrombosis (including complicated lesions of the heart valve apparatus, atrial fibrillation, cerebral vascular disease or coronary artery disease);
uncontrolled moderate or severe arterial hypertension with blood pressure 160/100 mmHg. Art. and more);
precursors of thrombosis (including transient ischemic attack, angina), incl. in the anamnesis;
migraine with focal neurological symptoms, incl. in the anamnesis;
venous or arterial thrombosis/thromboembolism (including deep vein thrombosis of the leg, embolism pulmonary artery, myocardial infarction, stroke) currently or in history;
the presence of venous thromboembolism in relatives;
major surgery with prolonged immobilization;
diabetes mellitus (with the presence of angiopathy);
pancreatitis (including a history), accompanied by severe hypertriglyceridemia;
dyslipidemia;
severe liver diseases, cholestatic jaundice (including during pregnancy), hepatitis, incl. history (before normalization of functional and laboratory parameters and within 3 months after these parameters return to normal);
jaundice due to taking drugs containing steroids;
gallstone disease currently or in history;
Gilbert, Dubin-Johnson, Rotor syndrome;
liver tumors (including history);
severe itching, otosclerosis or progression of otosclerosis during a previous pregnancy or while taking corticosteroids;
hormone dependent malignant neoplasms genitals and mammary glands (including suspicion of them);
vaginal bleeding of unknown etiology;
smoking over the age of 35 (more than 15 cigarettes per day);
pregnancy or suspicion of it;
lactation.
Carefully: conditions that increase the risk of developing venous or arterial thrombosis/thromboembolism (age over 35 years, smoking, hereditary predisposition to thrombosis - thrombosis, myocardial infarction or disorder cerebral circulation at a young age from one of the closest relatives); hemolytic uremic syndrome; hereditary angioedema; liver diseases; diseases that first appeared or worsened during pregnancy or against the background of previous use of sex hormones (including porphyria, herpes of pregnant women, minor chorea - Sydenham's disease, Sydenham's chorea, chloasma); obesity (body mass index more than 30); dyslipoproteinemia; arterial hypertension; migraine; epilepsy; valvular heart defects; atrial fibrillation; long-term immobilization; extensive surgery; surgical intervention on lower limbs; severe injury; varicose veins veins and superficial thrombophlebitis; postpartum period (non-lactating women - 21 days after birth; lactating women - after completion of the lactation period); presence of severe depression, incl. in the anamnesis; changes in biochemical parameters (activated protein C resistance, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, lupus anticoagulant); diabetes mellitus not complicated by vascular disorders; systemic lupus erythematosus (SLE); Crohn's disease; ulcerative colitis; sickle cell anemia; hypertriglyceridemia (including family history); spicy and chronic diseases liver.
Use during pregnancy and breastfeeding
The use of the drug during pregnancy and breastfeeding is contraindicated.
Side effects
Side effects that require immediate discontinuation of the drug:
Arterial hypertension;
Hemolytic-uremic syndrome;
Porphyria;
Hearing loss caused by otosclerosis.
Rarely found - arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism); exacerbation of reactive SLE.
Very rare - arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins; Sydenham's chorea (passing after discontinuation of the drug).
Other side effects, less severe, but more common - the advisability of continuing to use the drug is decided individually after consultation with a doctor, based on the benefit/risk ratio.
From the reproductive system: acyclic bleeding/ bloody issues from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, the development of inflammatory processes in the vagina (for example, candidiasis), changes in libido.
From the mammary glands: tension, pain, breast enlargement, galactorrhea.
From the gastrointestinal tract and hepatobiliary system: nausea, vomiting, diarrhea, epigastric pain, Crohn's disease, ulcerative colitis, hepatitis, liver adenoma, the occurrence or exacerbation of jaundice and/or itching associated with cholestasis, cholelithiasis.
From the skin: erythema nodosum/exudative, rash, chloasma, increased hair loss.
From the side of the central nervous system: headache, migraine, mood changes, depression.
Metabolic disorders: fluid retention in the body, change (increase) in body weight, increased triglycerides and blood sugar, decreased tolerance to carbohydrates.
From the senses: hearing loss, increased sensitivity of the cornea when wearing contact lenses.
Other: allergic reactions.
Interaction
The contraceptive effect of oral contraceptives is reduced with simultaneous use of rifampicin, breakthrough bleeding and menstrual irregularities become more frequent. Similar, but less studied, interactions exist between contraceptives and carbamazepine, primidone, barbiturates, phenylbutazone, phenytoin and presumably griseofulvin, ampicillin and tetracyclines. During treatment with the above drugs, simultaneously with oral contraception, it is recommended to use an additional method of contraception (condom, spermicidal gel). After completion of the course of treatment, the use of an additional method of contraception should be continued for 7 days, in the case of treatment with rifampicin - for 4 weeks.
Interactions associated with drug absorption
During diarrhea, the absorption of hormones decreases (due to increased intestinal motility). Any drug that shortens the time a hormonal agent remains in the large intestine leads to low concentrations of the hormone in the blood.
Interactions related to drug metabolism
Intestinal wall. Drugs that undergo sulfation in the intestinal wall like ethinyl estradiol (for example, ascorbic acid) inhibit metabolism and increase the bioavailability of ethinyl estradiol.
Metabolism in the liver. Inducers of microsomal liver enzymes reduce the level of ethinyl estradiol in the blood plasma (rifampicin, barbiturates, phenylbutazone, phenytoin, griseofulvin, topiramate, hydantoin, felbamate, rifabutin, oxcarbazepine). Liver enzyme blockers (itraconazole, fluconazole) increase the level of ethinyl estradiol in the blood plasma.
Effect on intrahepatic circulation. Some antibiotics (for example, ampicillin, tetracycline), by interfering with the intrahepatic circulation of estrogens, reduce the level of ethinyl estradiol in plasma.
Effect on the metabolism of other drugs
By blocking liver enzymes or accelerating conjugation in the liver, mainly increasing glucuronidation, ethinyl estradiol affects the metabolism of other drugs (for example, cyclosporine, theophylline), leading to an increase or decrease in their plasma concentrations.
The simultaneous use of St. John's wort preparations is not recommended ( Hypericum perforatum) with Lindinet 20 tablets (due to a possible decrease in the contraceptive effect of the active ingredients of the contraceptive, which may be accompanied by breakthrough bleeding and unwanted pregnancy). St. John's wort activates liver enzymes; after stopping the use of St. John's wort, the effect of enzyme induction may persist for the next 2 weeks.
Concomitant use of ritonavir and a combined contraceptive was associated with a 41% decrease in the mean AUC of ethinyl estradiol. During treatment with ritonavir, it is recommended to use a drug with a higher ethinyl estradiol content or a non-hormonal method of contraception. It may be necessary to adjust the dosage regimen when using hypoglycemic agents, because oral contraceptives may decrease carbohydrate tolerance and increase the need for insulin or oral antidiabetic agents.
Directions for use and doses
Inside, without chewing, drinking plenty of water, regardless of meals.
Take 1 tablet. per day (at the same time of day if possible) for 21 days. Then, after taking a 7-day break from taking the tablets, resume oral contraception (i.e. 4 weeks after taking the 1st tablet, on the same day of the week). During the 7-day break, uterine bleeding occurs as a result of hormone withdrawal.
First dose of the drug: Taking Lindinet 20 should start from the 1st to the 5th day of the menstrual cycle.
Switching from a combined oral contraceptive to taking Lindinet 20. 1st table Lindinet 20 is recommended to be taken after taking the last hormone-containing tablet of the previous drug, on the 1st day of withdrawal bleeding.
Transition from progestogen-containing drugs (mini-tablets, injections, implant) to taking Lindinet 20. The transition from mini-pills can be started on any day of the menstrual cycle; in the case of an implant - the day after its removal; in case of injections - on the eve of the last injection.
In this case, in the first 7 days of taking Lindinet 20, it is necessary to use an additional method of contraception.
Taking Lindinet 20 after an abortion in the first trimester of pregnancy. You can start taking contraceptives immediately after an abortion, and there is no need to use an additional method of contraception.
Taking Lindinet 20 after childbirth or after an abortion in the second trimester of pregnancy. You can start taking the contraceptive on days 21-28 after childbirth or abortion in the second trimester of pregnancy. If you start taking a contraceptive later, in the first 7 days, it is necessary to use an additional, barrier method of contraception. In the case where sexual intercourse took place before the start of contraception, before starting to take the drug, you should exclude the presence of a new pregnancy or wait until the next menstruation.
Missed pills. If the next scheduled dose of the tablet was missed, then you should make up for the missed dose as soon as possible. If the delay does not exceed 12 hours, the contraceptive effect of the drug is not reduced, and there is no need to use an additional method of contraception. The remaining tablets are taken as usual.
If there is a delay of more than 12 hours, the contraceptive effect may be reduced. In such cases, you should not make up for the missed dose, continue taking the drug as usual, but in the next 7 days you must use an additional method of contraception. If at the same time there are less than 7 tablets left in the package, then take the tablets from the next package without taking a break. In such cases, uterine withdrawal bleeding occurs only after the completion of the 2nd pack; While taking tablets from the 2nd package, spotting or breakthrough bleeding is possible.
If, upon completion of taking the tablets from the 2nd package, withdrawal bleeding does not occur, then pregnancy should be excluded before continuing to take the contraceptive.
Measures to be taken in case of vomiting and diarrhea. If vomiting occurs in the first 3-4 hours after taking another tablet, the tablet is not completely absorbed. In such cases, you should act in accordance with the instructions described in paragraph Missed pills.
If the patient does not want to deviate from her usual contraceptive regimen, the missed pills should be taken from another package.
Delay of menstruation and acceleration of the onset of menstruation. In order to delay menstruation, take pills from a new package without taking a break. Menstruation can be delayed at will until all the tablets from the 2nd package are gone. If menstruation is delayed, breakthrough or spotting uterine bleeding is possible. You can return to your usual pill intake after a 7-day break.
In order to achieve an earlier onset of menstrual bleeding, you can shorten the 7-day break by the desired number of days. The shorter the break, the more likely it is that breakthrough or spotting bleeding will occur while taking tablets from the next package (similar to cases with delayed menstruation).
Overdose
Taking large doses of the contraceptive was not accompanied by the development of severe symptoms.
Symptoms: nausea, vomiting, and in young girls, slight vaginal bleeding.
Treatment: symptomatic, there is no specific antidote.
special instructions
Before starting to use the drug, it is recommended to collect a detailed family and personal history and subsequently undergo a general medical and gynecological examination every 6 months (examination by a gynecologist, examination of a cytological smear, examination of the mammary glands and liver function, monitoring of blood pressure, cholesterol concentrations in the blood, urine analysis). These studies must be repeated periodically due to the need for timely identification of risk factors or contraindications that have arisen.
The drug is a reliable contraceptive drug - the Pearl index (an indicator of the number of pregnancies that occurred during the use of a contraceptive method in 100 women over 1 year) with correct use is about 0.05. Due to the fact that the contraceptive effect of the drug from the start of administration is fully manifested by the 14th day, it is recommended to additionally use non-hormonal methods of contraception in the first 2 weeks of taking the drug.
In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception. The woman's health condition must be carefully monitored.
If any of the following conditions/diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:
Diseases of the hemostatic system;
Conditions/diseases predisposing to the development of cardiovascular and renal failure;
Epilepsy;
Migraine;
The risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
Diabetes mellitus not complicated by vascular disorders;
Severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B 6 can be used for correction);
Sickle cell anemia, because in some cases (for example, infections, hypoxia), estrogen-containing drugs for this pathology can provoke thromboembolism;
The appearance of abnormalities in laboratory tests assessing liver function.
Thromboembolic diseases
Epidemiological studies have shown that there is an association between taking oral hormonal contraceptives and an increased risk of arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic diseases has been proven, but it is significantly less than during pregnancy (60 cases per 100 thousand pregnancies). When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.
The risk of arterial or venous thromboembolic disease increases:
With age;
When smoking (heavy smoking and age over 35 years are risk factors);
If you have a family history of thromboembolic diseases (for example, parents, brother or sister). If you suspect a genetic predisposition, you should consult a specialist before using the drug;
For obesity (body mass index above 30);
For dislipoproteinemia;
For arterial hypertension;
For diseases of the heart valves complicated by hemodynamic disorders;
With atrial fibrillation;
For diabetes mellitus complicated by vascular lesions;
With prolonged immobilization, after major surgery, surgery on the lower extremities, severe trauma.
In these cases, temporary cessation of use of the drug is assumed. It is advisable to stop no later than 4 weeks before surgery, and resume no earlier than 2 weeks after remobilization.
The risk of venous thromboembolic diseases increases in women after childbirth.
Diseases such as diabetes mellitus, SLE, hemolytic-uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, increase the risk of developing venous thromboembolic diseases.
Biochemical abnormalities such as resistance to activated protein C, hyperhomocysteinemia, protein C and S deficiency, antithrombin III deficiency, and the presence of antiphospholipid antibodies increase the risk of arterial or venous thromboembolic diseases.
When assessing the benefit/risk ratio of taking the drug, it must be borne in mind that targeted treatment of this condition reduces the risk of thromboembolism.
Signs of thromboembolism are:
Sudden chest pain that radiates to the left arm;
Sudden shortness of breath;
Any unusually severe headache that continues for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of half the body, movement disorders, severe unilateral pain in the calf muscle, acute abdomen.
Tumor diseases
Some studies have reported an increased incidence of cervical cancer in women who took hormonal contraceptives for a long time, but the results of the studies are inconsistent. Sexual behavior, infection with the human papillomavirus and other factors play a significant role in the development of cervical cancer.
A meta-analysis of 54 epidemiological studies found that there was a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but the higher detection rate of breast cancer may have been associated with more regular medical screening. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be considered one of many risk factors. However, women should be made aware of the possible risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian, endometrial and colon cancer).
There are few reports of the development of benign or malignant tumor liver in women taking hormonal contraceptives for a long time. This should be kept in mind when diagnosing abdominal pain, which may be associated with an increase in liver size or intra-abdominal bleeding.
The woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.
The effectiveness of the drug may decrease in the following cases: missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.
If the patient is simultaneously taking another drug that may reduce the effectiveness of birth control pills, use additional methods contraception.
The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they run out in the next package. If at the end of the 2nd cycle menstrual-like bleeding does not begin or acyclic bleeding does not stop, you should stop taking the pills and resume it only after pregnancy has been ruled out.
Chloasma
Chloasma can occasionally occur in women who have a history of it during pregnancy. Those women who are at risk of developing chloasma should avoid contact with sun rays or UV while taking the pills.
Changes in laboratory parameters
Under the influence of oral contraceptive pills - due to the estrogen component - the level of some laboratory parameters (functional indicators of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.
After acute viral hepatitis, it should be taken after normalization of liver function (no earlier than 6 months). In case of diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease (without stopping the drug, it is necessary to use additional non-hormonal methods of contraception). Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35 years of age) and the number of cigarettes smoked. During lactation, milk secretion may decrease; in small quantities, the components of the drug are excreted in breast milk.
The effect of the drug on the ability to drive a car and operate machinery. Studies have not been conducted to study the possible effect of Lindinet 20 on the ability to drive a car or other machines.
I have been using Lindinet for a long time, for me it is the best type of contraception! Very convenient and how nice))
I started with Lindinet 20, but then some kind of failure occurred after the withdrawal, most likely the dose of the hormone was small, and I had to switch to Lindinet 30. What can I say about the differences? While taking 20, my stomach did not hurt before my period. Since 30, still It hurts. Sometimes it hurts a lot, sometimes not so much, but it’s still better than before taking contraceptives. Then I couldn’t get out of bed at all.
Do you know what the huge advantage of this product is for me? The discharge during menstruation is minimal! I don’t buy pads at all, I use daily pads. My period lasts 3 days, literally a few drops per day.
Second plus: if for some reason you need to prevent your period, then it is very simple to do this: after drinking 21 tablets, you do not take a seven-day break, but start drinking the next pack immediately. I do this periodically, no problems have arisen. PMS on the days of your expected period doesn’t bother you either. In general, it’s very, very convenient. You need to be prepared that when your period does come (at the end of the second pack), it may be heavier than usual.
Dear girls! If you decide to use hormonal contraceptives, be prepared for the fact that it may not be possible to make love without lubrication! I use this and this as a lubricant. Just don’t try to combine the first with condoms! Unless, of course, you want a baby.
I do not include instructions, because they are HUGE! You can find them on the Internet
I will only include the most important ones.
And now I’ll tell you how I once bought Lindinet 30. So, I decided to buy myself 3 packs, in reserve. I went to one of the cheapest pharmacies, bought 1 pack for 543 rubles. I thought it was a little expensive, so I didn’t buy 2 more .And in the evening, when I was walking with my loved one, I looked into another pharmacy, and there... There, one pack (from one batch) cost 327 rubles, but this pack was the last, and they gave me another (from another batch) it cost 407 r.. Such is the fun in our pharmacies!
So don’t rush to take it right away, it’s better to find out the price of the medicine in different pharmacies.
Happy shopping and good sex to everyone!)))))