Penicillin- a legendary drug. It began the era of antibiotics, which saved millions of human lives. This remedy is still used in the treatment of certain infections. Today it is fashionable to criticize antibiotics, attributing to them all conceivable and inconceivable shortcomings. But with the advent of penicillin, the world changed forever and certainly became a better place.

Who discovered Penicillin?

At the beginning of the 20th century, a means to combat infections became a necessity. The population grew, especially in industrial cities. And with such crowding, any infection threatened a large-scale epidemic.

Scientists already knew a lot about bacteria, the causative agents of the most common and dangerous diseases were isolated and studied, and some drugs were used. But there was no truly effective medicine.

At the end of the 20s of the last century (1881 - 1955), he actively studied pathogenic microorganisms, including staphylococci - the cause of many diseases.

History of discovery

The literature, including fiction, colorfully describes that the Scottish scientist was careless and did not deactivate the bacterial cultures immediately after working with them. And one day he noticed that the growing mold had dissolved the colonies in one of the Petri dishes.

You need to understand that this was not ordinary mold, but brought from a neighboring laboratory. It turned out that it belongs to the genus Penicillium (penicillum). There were doubts about its variety, but experts determined that it was penicillium notatum.

Fleming began growing this fungus in bottles of nutrient broth and conducting tests. It turned out that even with strong dilution, this antiseptic is able to suppress the growth and reproduction of not only staphylococcus, but also other pathogenic cocci (gonococcus, pneumococcus), and diphtheria bacillus. At the same time, cholera virions, typhus and paratyphoid pathogens did not respond to the action of penicillium notatum.

But the main questions were how to isolate a pure substance that destroys bacteria, how to maintain its activity for a long time? - There was no answer to them. Fleming tried to use the broth topically - for treating purulent wounds, for instillation into the eyes and nose (for rhinitis). But massive research has reached a dead end.

In the 40s, attempts to isolate pure penicillin were continued by the so-called Oxford group of microbiologists. Howard Walter Florey and Ernest Chain obtained a powder that could be diluted and injected.

Research was spurred by the Second World War. In 1941, the Americans joined the research and invented a more effective technology for producing penicillin. This medicine was necessary at the fronts, where any wound and even just abrasion threatened blood poisoning and death.

The Soviet government asked the Allies to provide a new medicine, but received no response. Then the Institute of Experimental Medicine, headed by Z. V. Ermolyeva. Several dozen variants of the Penicillium fungus were studied and the most active one was isolated - Penicillium crustosum. In 1943, domestic “penicillin-crustosin” began to be produced on an industrial scale.

This drug turned out to be more effective than the American one. Flory himself visited Moscow to verify this. He, too, wanted to get the original culture of our antibiotic. He was not refused, but was given Penicillium notatum, already known in the West.

Modern concept of antibiotics

Antimicrobial drugs today are divided into many groups. According to the production method they are divided into:

1. Biosynthetic - natural - they are isolated from cultures of microorganisms;
2. Semi-synthetic - they are obtained by chemical modification of substances secreted by microorganisms.

The classification by chemical composition is widely used:

• β-lactams - penicillin, cephalosporin, etc.;
• Macrolides - erythromycin, etc.;
• Tetracyclines and so on.

Antibiotics are also divided according to their spectrum of action: broad spectrum, narrow spectrum. By predominant effect:

1. bacteriostatic - stop bacterial division;
2. bactericidal - destroy adult forms of bacteria.

Modern penicillin and natural antibiotics

Today the ancestor of all antibiotics is called benzylpenicillin. This is a β-lactam natural bactericidal drug. In its pure form it does not have a wide spectrum of action. Some types of gram-negative bacteria, anaerobes, spirochetes and some other pathogens are sensitive to it.

Most of the “claims” that people now like to make about all antibiotics can be attributed to natural penicillins:

1. They often cause allergies - immediate and delayed reactions. Moreover, this applies to any products that contain penicillin, including cosmetics and food products.
2. The toxic effect of penicillins on the nervous system, mucous membranes (inflammation occurs), and kidneys has also been described.
3. When some microorganisms are suppressed, others can multiply enormously. This is how superinfections arise - for example,.
4. This medicine must be administered in injections - it is destroyed in the stomach. In addition, the drug is eliminated quickly, requiring frequent injections.
5. Many strains of microorganisms have or are developing resistance to its action. People who misuse the antibiotic are often to blame.

But it is important to understand that such (and a wider) list of undesirable effects of penicillins appeared thanks to their excellent study. All these disadvantages do not make this drug “poisonous” and do not cover up the obvious benefits that it still brings to patients.

Suffice it to say that all international medical organizations have recognized the possibility of treating pregnant women with penicillin.

To expand the spectrum of action of a natural antibiotic, it is combined with substances that destroy bacterial defenses - β-lactamase inhibitors (sulbactam, clavulonic acid, etc.). Long-acting forms have also been developed.

Modern semi-synthetic modifications help overcome the disadvantages of natural penicillin.

Antibiotics of the penicillin group

Natural penicillins:

• benzylpenicillin (penicillin G);
• phenoxymethylpenicillin (penicillin V);
• benzathine benzylpenicillin;
• benzylpenicillin procaine;
• benzathine phenoxymethylpenicillin.

Semi-synthetic penicillins:

Extended spectrum of action -

Against Pseudomonas aeruginosa -

• Ticarcillin;
• Azlocillin;
• Piperacillin;

Against staphylococcus -

• Oxacillin;

Combined with beta-lactamase inhibitors -

• Ampicillin/sulbactam.

How to dilute penicillin

Whenever an antibiotic is prescribed, the doctor must indicate the exact dose and dilution ratio. Trying to “guess” them on your own will lead to dire consequences.

The dilution standard for penicillin is 100,000 units per 1 ml of solvent (this can be sterile water for injection or saline). Different solvents are recommended for different drugs.

For the procedure you will need 2 syringes (or 2 needles) - for dilution and for injection.

1. Following the rules of asepsis and antiseptics, open the ampoule with the solvent and draw the required amount of liquid.
2. Puncture the rubber cap of the bottle with penicillin powder with a needle at a 90-degree angle. The tip of the needle should appear no more than 2 mm from the inside of the cap. Add the solvent (required amount) into the bottle. Disconnect the syringe from the needle.
3. Shake the bottle until the powder is completely dissolved. Place the syringe on the needle. Turn the bottle upside down and draw the required dose of medication into the syringe. Remove the bottle from the needle.
4. Change the needle to a new one - sterile, closed with a cap. Give an injection.

It is necessary to prepare the drug immediately before the injection - the activity of penicillin in the solution decreases sharply.

I was interested in the question: is it possible to obtain antibiotics at home? For example, penicillin?
Curious how dependent we are on society??? In 2010, could an ordinary person help himself cope with sore throat, pneumonia, sepsis, etc.? creating enough medicine without the risk of poisoning? I'm not a doctor, but I'll try to figure it out...

Penicillin ( Benzylpenicillin) is the first antibiotic, that is, an antimicrobial drug obtained from the waste products of microorganisms.

Family Mucedinaceae. Class imperfect fungi.
Among the mushrooms widespread in nature, green racemose molds belonging to the genus Penicillium, many species of which are capable of producing penicillin, are of greatest importance for medicinal purposes. Penicillin aureus is used to produce penicillin. This is a microscopic mushroom with septate branched mycelium that makes up the mycelium. On artificial nutrient media it forms giant colonies. On the 12-14th day of growth on Czapek agar medium, the colonies are velvety, 30-40 mm in diameter, sometimes with scattered aerial hyphae, greenish-blue, then green, with a white edge during the growth period; with age, acquiring a brownish tint, with abundant colorless or yellow drops of exudate on the surface. The reverse side of the colony is yellow or brownish-yellow. The surrounding agar turns yellow. Special hyphae develop on the mycelium - conidiophores, which carry spores. In the production of penicillin, only selected strains that do not produce a yellow pigment are currently used. Most of these strains originate from a pigmentless mutant of this species, obtained by the action of ultraviolet rays on a pigment-forming strain. Derivatives of this strain, obtained by exposing it to ethyleneamine followed by selection, have the ability to produce up to 3-4 thousand units of penicillin in 1 ml of culture liquid. The morphological characteristics of these strains are as follows: the colony on the 12-14th day reaches 10-15 mm in diameter, strongly folded, convex or crater-shaped. The growing edge is very narrow and steep. A creamy-white colony with a faint greenish tint is not formed; the agar surrounding the colony is not colored. The mycelium is thickened with shortened swollen cells.
Penicillin is prepared as follows. The culture is carried out on media containing corn extract, which increases the yield of penicillin. The best carbohydrate for culture fluid is lactose. Adding phenylacetic acid and phenylacetamide to the nutrient medium at a concentration of 0.02-0.08% significantly increases the yield of penicillin, since these substances are included in the antibiotic molecule. Penicillin is grown using the submerged culture method in special fermenters with a capacity of several tons. Penicillin is extracted from the culture liquid by sequential treatment with organic solvents and weakly alkaline salt solutions, from which it then crystallizes in the form of sodium and potassium salts.
The active antimicrobial substances contained in the culture liquid of penicillin producers are a mixture of various penicillins. Different types of penicillin have the same main core and different side chains (radicals). All of them are heterocyclic compounds, the molecules of which are based on a bicyclic system built from fused thiazolidine and p-lactam rings. Currently, over 10 natural penicillins containing various radicals are known. Industrial (medicinal) penicillin contains predominantly benzylpenicillin. Currently, it is also used in medical practice phenoxymethylpenicillin (penicillin - PAA), which is not destroyed by gastric juice and can be administered orally. Its precursor is phenoxymethylacetic acid, which is added to the culture medium.
Penicillin is a highly effective antibacterial agent, widely used in medical practice for the treatment of diseases caused by streptococcus, staphylococcus, meningococcus, pneumococcus, gonococcus and other pathogenic aerobic bacteria. It is used in the form of sodium, potassium and other salts for sepsis and wound infection, pneumonia, acute and subacute septic endocarditis, purulent skin infection, septicemia and pyaemia, osteomyelitis, tonsillitis, gonorrhea, syphilis and other diseases. The most effective is intramuscular and intravenous administration of benzylpenicillin. It is also injected into serous cavities, joints, abscesses, fistulas for poliomyelitis; bandages soaked in penicillin are applied to infected wounds and ulcers; it is recommended for rinsing and in tablet form for sore throats. Phenoxypenicillin is used orally in tablet form in the same cases as benzylpenicillin. Well-purified penicillins are practically non-toxic.
Preparations - crystalline penicillin (sodium and potassium salts of benzylpenicillin), penicillin - calcium salt, novocaine salt of penicillin, etc.

Conclusion: I wouldn’t risk doing this at home... of the dozens of varieties of mushrooms, most are toxic... it’s difficult to get the right one and clean it.

Curious... about a sore throat... not sure about the authenticity
“Penicillin stopped acting on staphylococci more than 50 years ago - then strains resistant to penicillin appeared (the so-called PRSA - penicillin-resistant strains of Staphylococcus aureus or penicillin-resistant Staphylococcus aureus). Thus, at present, the vast majority of all strains of Staphylococcus aureus are resistant to penicillin. Over time, a number of other antibiotics ceased to act on staphylococci - this microorganism became resistant (resistant) to them. Such bacteria are called MRSA (methicillin-resistant Staphylococcus aureus), and they are resistant to all antibiotics of the penicillin group, as well as same as a whole range of antibacterial drugs from other groups."

You can read it in great detail and interestingly here... Biological encyclopedia Based on the publications: "The Life of Animals" in 6 volumes (Publishing House "Prosveshchenie": M., 1970, edited by professors N.A. Gladkov, A.V. Mikheev) and “The Life of Plants” in 6 volumes (Publishing house “Prosveshchenie”, M., 1974, edited by A. L. Takhtadzhyan, editor-in-chief, corresponding member of the USSR Academy of Sciences, Prof. A. A. Fedorov).

In conditions of extreme survival, any wound can take months to heal, frostbite will certainly lead to gangrene, and mild inflammation can cause blood poisoning, so you don’t even need to mention such serious diseases as pneumonia.

However, nature has taken good care of us, providing a wide range of natural antibiotics and medicinal herbs, the magical effects of which, unfortunately, today are mostly known only to shamans and village grannies.

Propolis

There is no misfortune that this natural antibiotic with a very wide spectrum of action cannot help with. It will strengthen the immune system, heal wounds with burns, frostbite and cracks, kill all types of fungi, even meat coated with this unique waste product of bees can not spoil after a long stay in the scorching sun. Do you have a problem? Propolis will solve it. Therefore, if, finding yourself in an extreme situation, you still decide to climb into the hive with the bees and take their honey, do not forget to take propolis at the same time (it smells like incense when burning). Depending on the location of the disease, there are several ways to prepare propolis-based medicines at home:

Ointment: To make a medicinal ointment based on propolis, we will need 15-20 grams of propolis for 100 grams of any oily base (olive or any other unrefined vegetable oil is best), after which the mixture must be boiled in a water bath for an hour, stirring occasionally with a wooden with a stick. You can replace the oily base with butter by adding 5 ml of water, in which case the boiling time is reduced to 15 minutes. Before use, it is advisable to filter the solution through 2 layers of gauze. Store in a dark container in a dark, cool place.

Oral tincture: Let 10 grams of propolis steep in 100 ml of water (50 degrees C) for 24 hours and you will get a pleasant-smelling yellowish aqueous solution with a shelf life of up to one week in a cool place. The daily safe dose is 2 tablespoons 4 times a day an hour before meals.

And may the power of the bees be with you.

Treatment with penicillin, which was the first antibiotic discovered and was widely used at the beginning of the last century, will get rid of a bacterial infection or kill you if you are allergic to it. However, if you find yourself far from the nearest settlement and become seriously ill (not with a viral disease), this may be the only natural antibiotic that can still save your life.

How to get penicillin. Instructions: To get penicillin, you don’t have to go far, just open the refrigerator and find cheese with green mold, but it’s not a fact that this mold will be the penicillin fungus, and even if it is, the concentration of antibiotic in it is unlikely to be enough for use in as a treatment for bacterial infections, otherwise in case of illness, doctors would simply stupidly prescribe to eat mold. If there are no other options, and even magic propolis did not help you, you can get penicillin as follows:

Take a piece of bread or a slice of citrus and leave it to deteriorate in an environment of 21 degrees Celsius. After the greenish-bluish mold appears, cut the bread or lemon into pieces, placing them in a pre-sterilized conical flask, in the dark at 21 degrees Celsius, for five days.

It is very likely that after five days without antibiotics for a bacteriological disease, you are unlikely to need penicillin, however, nevertheless, prepare a nutrient medium for future mold colonies by dissolving the following ingredients in half a liter of cold water in the sequence indicated here: 44 grams of Lactose (you can replace with glucose, sucrose, etc., while ensuring their continuous supply), 25 g corn starch, 3 g sodium nitrate, 0.25 g magnesium sulfate, 0.5 g monocalcium phosphate, 2.75 g glucose monohydrate, 0.044 g zinc sulfate and 0.044 manganese sulfate. Now add cold water so that the total volume is 1 liter, and use perchloric acid to adjust the pH of the culture between 5.0 and 5.5.

Pour the nutrient medium into bottles, such as milk bottles, sterilize them, then add a teaspoon of mold spores. To obtain penicillin, all that remains is to let the bottles brew for 7 days, under the same conditions, then filter the liquid with the nutrient medium and freeze it as soon as possible to avoid decomposition of the finished penicillin.

It is better to treat with penicillin immediately and ONLY if there is no suitable alternative. As a strong antibiotic, it is capable of combating both blood poisoning and any bacteriological pathogen, but one must be aware that the penicillin obtained in the manner described above will contain admixtures of toxic types of mold, and it is very likely that these strains can slow down, and or even completely prevent the release of penicillin, which will lead to even greater bacteriological infection of your body. In addition, it must be borne in mind that penicillin is an allergen and can cause anaphylactic shock in some people, which in extreme conditions is tantamount to death.

“When I woke up at dawn on September 28, 1928, I certainly did not plan to revolutionize medicine with my discovery of the world’s first antibiotic or killer bacteria,” he wrote in his diary. Alexander Fleming, the man who invented penicillin.

The idea of ​​using microbes to fight germs dates back to the 19th century. It was already clear to scientists that in order to combat wound complications, we must learn to paralyze the microbes that cause these complications, and that microorganisms can be killed with their help. In particular, Louis Pasteur discovered that anthrax bacilli are killed by the action of certain other microbes. In 1897 Ernest Duchesne used mold, that is, the properties of penicillin, to treat typhus in guinea pigs.

In fact, the date of invention of the first antibiotic is September 3, 1928. By this time, Fleming was already famous and had a reputation as a brilliant researcher; he studied staphylococci, but his laboratory was often untidy, which was the reason for the discovery.

Penicillin. Photo: www.globallookpress.com

On September 3, 1928, Fleming returned to his laboratory after a month of absence. Having collected all the cultures of staphylococci, the scientist noticed that mold fungi appeared on one plate with the cultures, and the colonies of staphylococci present there were destroyed, while other colonies were not. Fleming attributed the mushrooms that grew on the plate with his cultures to the genus Penicillium, and named the isolated substance penicillin.

During further research, Fleming noticed that penicillin affected bacteria such as staphylococci and many other pathogens that cause scarlet fever, pneumonia, meningitis and diphtheria. However, the remedy he isolated did not help against typhoid fever and paratyphoid fever.

As Fleming continued his research, he discovered that penicillin was difficult to work with, production was slow, and penicillin could not survive in the human body long enough to kill bacteria. Also, the scientist could not extract and purify the active substance.

Until 1942, Fleming improved the new drug, but until 1939 it was not possible to develop an effective culture. In 1940, a German-English biochemist Ernst Boris Chain And Howard Walter Flory, an English pathologist and bacteriologist, were actively involved in trying to purify and isolate penicillin, and after some time they were able to produce enough penicillin to treat the wounded.

In 1941, the drug was accumulated on a sufficient scale for an effective dose. The first person to be saved with the new antibiotic was a 15-year-old boy with blood poisoning.

In 1945, Fleming, Florey and Chain were awarded the Nobel Prize in Physiology or Medicine "for their discovery of penicillin and its beneficial effects in various infectious diseases."

The value of penicillin in medicine

At the height of World War II in the United States, the production of penicillin had already been put on the conveyor belt, which saved tens of thousands of American and allied soldiers from gangrene and amputation of limbs. Over time, the method of producing the antibiotic was improved, and since 1952, relatively cheap penicillin began to be used on an almost global scale.

With the help of penicillin, you can cure osteomyelitis and pneumonia, syphilis and puerperal fever, and prevent the development of infections after wounds and burns - previously all these diseases were fatal. During the development of pharmacology, antibacterial drugs of other groups were isolated and synthesized, and when other types of antibiotics were obtained.

Drug resistance

For several decades, antibiotics became almost a panacea for all diseases, but even the discoverer Alexander Fleming himself warned that penicillin should not be used until the disease is diagnosed, and the antibiotic should not be used for a short time and in very small quantities, since under these conditions Bacteria develop resistance.

When pneumococcus that was not sensitive to penicillin was identified in 1967, and antibiotic-resistant strains of Staphylococcus aureus were discovered in 1948, scientists realized that.

“The discovery of antibiotics was the greatest benefit for humanity, the salvation of millions of people. Man created more and more new antibiotics against various infectious agents. But the microcosm resists, mutates, microbes adapt. A paradox arises - people are developing new antibiotics, but the microcosm is developing its own resistance,” said Galina Kholmogorova, senior researcher at the State Research Center for Preventive Medicine, candidate of medical sciences, expert of the National Health League.

According to many experts, the fact that antibiotics lose their effectiveness in fighting diseases is largely to blame for the patients themselves, who do not always take antibiotics strictly according to indications or in the required doses.

“The problem of resistance is extremely large and affects everyone. It causes great concern among scientists; we can return to the pre-antibiotic era, because all microbes will become resistant, not a single antibiotic will act on them. Our inept actions have led to the fact that we may find ourselves without very powerful drugs. There will simply be nothing to treat such terrible diseases as tuberculosis, HIV, AIDS, malaria,” explained Galina Kholmogorova.

That is why antibiotic treatment must be treated very responsibly and a number of simple rules must be followed, in particular:

Surprisingly, only a few years ago the use of whiskey in cocktails was considered extremely bad taste. According to many tasters, this is a senseless spoilage of exquisite alcohol, which is unique and beautiful only in its pure form.

However, time passed, and young bartenders went against the bigwigs of bar culture and, with enviable regularity, produced amazing mixes, the alcoholic base of which was whiskey. One of the most successful experiments was the Penicillin cocktail, invented by the famous New York bartender Sam Ross in 2005.

According to the colleagues of the famous mixologist, he made a discovery and said a new word in the difficult matter of creating alcoholic cocktails. Let's look at the complex technology for preparing this strong drink.

The process of making an original mix from Sam Ross will not cause you any difficulties or problems. Follow the described instructions exactly and you will be able to pleasantly surprise your guests and loved ones with the indescribable taste and incomparable aroma of the intoxicating drink.

According to the author of this alcohol, special attention should be paid to the choice of whiskey, the main task of which is to balance and harmonize the rich aromas of honey and ginger - Scottish blended alcohol is best suited.

Also pay close attention to the order in which the mix is ​​“assembled”: citrus fruits are added first, sweet ones come next, and alcoholic components come last. Ice is added only as a last resort, as it quickly begins to melt and reduces the taste of the drink.

Required Ingredients

1. First of all, let's prepare honey syrup. To do this, mix honey and water in a 3:1 ratio in an enamel pan. Bring the liquid to a boil and simmer over medium heat for at least 3 minutes, constantly and intensively stirring the mixture and removing any foam that has formed from the surface. After this, remove the syrup from the heat and allow it to cool naturally to room temperature, while stirring the mass from time to time with a wooden spoon.
2. Peel the fresh ginger root and grate it on a fine grater, then put the resulting pulp in a gauze cloth folded in 3-4 layers and carefully squeeze out the juice.
3. Squeeze the lemon juice in any convenient way, then filter it through a gauze filter or a fine strainer.
4. Now pour the ingredients into the shaker one by one: first fresh lemon juice, then honey syrup, and then ginger juice.
5. Shake the components for 5-7 seconds.
6. Add a couple of ice cubes and blended alcohol.
7. Shake the ingredients again for at least 10 seconds.
8. Pour the resulting liquid mixture through a strainer directly into a chilled glass like a rocks glass.
9. Pour single malt alcohol on top in a thin stream and do not stir the mix under any circumstances.
10. Carefully place the remaining ice cubes and a spiral decoration of lemon zest into the strong drink.
11. We enjoy Penicillin alcohol through a straw, sipping the liquid in small sips.

Simplified Penicillin cocktail recipe

Not everyone is a fan of long and painstaking preparation of cocktails. For such cases, a simplified version of the Penicillin cocktail was invented, which anyone can repeat.

Required Ingredients

Manufacturing sequence

1. Wash the lemon thoroughly and wipe dry with a paper towel.
2. Carefully cut a beautiful spiral from a clean citrus to decorate the mix.
3. Carefully squeeze the juice from a whole lemon, removing the seeds and pulp.
4. Grate the required amount of fresh ginger root on a fine grater.
5. Alternately add fresh lemon juice, chopped ginger, ginger syrup and the white of one chicken egg into the shaker.
6. Shake the ingredients very intensively for at least 40 seconds.
7. Open the shaker and add a couple of ice cubes and strong alcohol.
8. Beat the mixture again for 20 seconds.
9. Pour the finished alcoholic drink into a pre-chilled glass, filtering it through a strainer.
10. Before actual tasting, dip a couple of ice cubes into the liquid and decorate the intoxicating drink with lemon zest.

Cocktail recipe Pink penicillin

Despite its rather sweet and innocent appearance, this mix is ​​known as one of the most lethal alcoholic drinks. This version of the popular alcohol has a strong intoxicating effect, and not every consumer will remain on his feet and in a conscious state after the second serving of this intoxicating drink. Therefore, weigh everything carefully and think about it before you start tasting the Pink Penicillin cocktail.

Required Ingredients

Manufacturing sequence

1. Alternately pour schnapps, liqueur, pomegranate syrup and blended whiskey into the shaker.
2. Drop a couple of ice cubes in there and vigorously shake the liquid ingredients for 15-20 seconds.
3. Place the egg white and heavy cream into a blender bowl and beat the ingredients until fluffy and smooth.
4. Transfer the resulting mixture into a shaker with the remaining ingredients and shake the shaker again for 10 seconds.
5. Pour the finished alcoholic drink into a glass pre-chilled to an icy state.
6. Drop a couple of ice cubes in there and garnish the mix with a thin slice of fresh lemon.

Cocktail recipe Tropical penicillin

This version of the legendary Penicillin also has a high strength and will be more to the liking of the stronger half of humanity. Not everyone will be able to drink more than two servings without prior preparation. The finished alcoholic cocktail has a wonderful citrus flavor intertwined with notes of sugary agave juice. The aroma is also interesting because it has a complex bouquet of different smells.

Required Ingredients

Manufacturing sequence

1. Fill the glass for the finished alcohol to the top with ice cubes and set it aside.
2. Pour freshly squeezed lemon juice into a shaker, then orange juice, and then add ginger syrup.
3. We also put a couple of large ice cubes and salt there.
4. Shake the contents of the shaker for at least 30 seconds so that the salt crystals are sure to dissolve in the liquid.
5. Now it’s time to add agave syrup and single malt whiskey to the shaker.
6. Mix the ingredients thoroughly, shaking the shaker vigorously for another 30 seconds.
7. We remove the ice from the glass and pour the finished alcoholic drink into it, passing it through a strainer or fine sieve.
8. We enjoy the strong drink through a straw, savoring every sip.

Penicillin cocktail recipe video

After watching the presented videos, you will have the opportunity to follow the step-by-step technology for preparing the famous Penicillin mix. Each video highlights the original recipe of experienced bartenders who have put a lot of effort into selecting proportions and suitable brands of alcoholic ingredients and creating a cocktail that is truly worth mentioning and tasting.

Video No. 1. Here is an almost classic version of the legendary Penicillin mix.

Video No. 2. In this video, some proportions have been changed, but the sequence of assembling the mix remains the same. The talented bartender will also provide a wonderful, custom garnish for the ginger-honey Penicillin.

Video No. 3. After viewing this material, you will learn how to prepare a stunning Penicillin cocktail based on scotch and fresh lime juice.

Helpful information

• If you are a beginner in such a difficult business as bar art, then check out the recipes for the most popular whiskey cocktails, which have become increasingly popular lately.
• Be sure to look at the technology for preparing the famous cocktail, which became the inspiration for Sam Ross, who made the mix discussed today.
• Of course, I can’t help but recommend mafia mix, the favorite alcoholic drink of the famous Vito Corleone from the film of the same name directed by Francis Ford Coppola.
• The last cocktail to which I want to draw your attention is called Old Fashioned, the alcoholic base of which is rye whiskey.

In general, there is nothing difficult in creating a delicious and aromatic Penicillin cocktail. A little desire, a little effort, and those around you begin to smile more often, laugh more and thank you for your good mood.

Feel free to experiment with the ingredients, and if you manage to cook something worthwhile and worthy of attention, be sure to describe the recipe in the comments. I am very grateful for your time and wish you success in the difficult task of cocktail art!