Analgin. What we are treated with: Analgin

banned all over the world, except for our country, it also affects the reproductive system (not in the best way, of course)

Is it true. And it also affects the liver and stomach. It is only good together with diphenhydramine in injections to bring down the temperature. And so in modern medicine they have almost abandoned it.

It’s not true, it has long been proven that it’s not on the heart, but on the liver.

In general, painkillers are one of the most popular medications in the home medicine cabinet, and analgin is the king and god among them. Migraine or teeth, painful menstruation, severe hangover - everything is “extinguished” by inexpensive and familiar analgin. In addition, it is taken as an antipyretic. True, analgin does not eliminate the cause of the ailment, but only muffles the unpleasant sensations, but it is precisely because of these properties that it is in such great demand. Did you know that Russian pharmaceuticals are one of the last bastions of resistance to the World Health Organization (WHO), which is fighting this universal drug.

WHO has long made a strict recommendation regarding analgin: its use should be limited as much as possible. In the USA, Norway, Great Britain, the Netherlands, Sweden, this medicine was excluded from the pharmacopoeia back in the 70s, and in general its consumption was forcibly reduced in 34 countries. Our pharmacologists, of course, know that analgin causes serious side effects. It suppresses the function of the bone marrow, limiting its production of white blood cells - red blood cells that protect the body from infections. In large doses, analgin can lead to death. But many women and girls suffering from painful periods simply revel in analgin during their “critical days,” bringing its consumption to several packs monthly! Analgin is cheaper than safer foreign drugs and can successfully compete with them. The Russian pharmaceutical company ICN alone, according to the newspaper Vremya MN, sells 8 thousand packs of analgin weekly through its network of pharmacies! This, apparently, lies the secret of our stubborn resistance to the alarming directives of WHO experts. True, changes have now been made to the instructions for use of this medicine, but to be frank, who carefully studies the instructions for over-the-counter medicines? The same taste, the same analgin.

yes, because it dilates blood vessels. If you take a large dose, it can lead to bad results

the use of analgin does not affect the functioning of the heart

No, analgin only thins the blood and should be used in the correct dosage and for its intended purpose.

analgin is already banned because it affects not only the heart, it can cause blood cancer

Is it true that the use of analgin affects the functioning of the heart?

Analgin and its “brothers” act directly on the peripheral nervous system. Their task is to suppress pain where it manifests itself. There is another type of analgesics - narcotics, which eliminate pain through the brain. The fact is that the body itself secretes painkillers - opiates. Narcotic analgesics are essentially artificial opiates that are added to natural ones to more effectively suppress unbearable pain - for example, in cancer. But the body senses that opiates are coming in large quantities from the outside, and stops producing its own. Drug dependence occurs. The next dose of opiates did not arrive - withdrawal began. Such narcotic analgesics are known to be sold strictly by prescription. But you can also get used to an over-the-counter painkiller if you do not treat your poor health, but only eliminate the pain symptoms. In principle, there are no harmless drugs; there are none among analgesics. It’s just that some have more side effects, others have fewer.

Analgin is a cheap painkiller, and it is profitable for the pharmaceutical industry to produce expensive painkillers that are no better than analgin, so the production of analgin is prohibited. It is good that Russia did not obey this ban.

The good old killer, or why analgin is banned

Analgin is one of the few drugs that do not need advertising. Since childhood, we have memorized the advice of mothers and grandmothers: “Does your head or stomach hurt?” Women's pain? Pain in the back, leg or arm. “- there is only one recipe: take analgin and everything will go away. The World Health Organization has been trying to eradicate the habit of swallowing the popular drug for five decades. Svidomo found out why.

The drug appeared in 1920. It was synthesized by the German chemist Ludwig Knorr. Half a century later, the triumphant spread of analgin around the world began to be replaced by a wave of alarming reports about dangerous side effects. Some doctors even claimed a mortality rate of 7% of use. In 1970, WHO recommended that all countries abandon analgin.

Now you can’t buy it in pharmacies in dozens of developed countries, for example: the USA, Canada, Britain, Germany, Norway, Denmark, Sweden, Australia and Japan. “Too high a health risk.” This is how the American Food and Drug Administration justified its ban on analgin back in 1977. Since then, evidence that the risk is “too high” has only grown.

In our country it is difficult to find a person who is not familiar with analgin. But it is even more difficult to find someone who would read the instructions before swallowing these pills. If you decide to do this, you will learn about three contraindications: if you are under 12; if you are allergic to any part of the pill; if you are pregnant. Even if this is not about you, further in the instructions there is a long list of side effects. From tinnitus to Lyell's syndrome. Symptoms of this syndrome are a sudden jump in temperature and a rash of painful blisters on the body that will come off along with the skin. But the biggest threat is getting a blood disease, agranulocytosis. This is when the number of leukocytes and granulocytes (white blood cells) in the blood, which protect our body from external and internal enemies, decreases. As a result, a person’s immunity decreases and he becomes susceptible to all kinds of infections, bacteria and fungi. It is because of this that the authoritative British textbook “Clinical Pharmacy” calls analgin “notorious.”

The British have confirmed this stigma with numerous studies. Interestingly, one of them was partially financed by the manufacturer of analgin, the Hoechst company. The study was conducted by the Department of Pharmacological Epidemiology at Boston University. Doctors analyzed patients from different hospitals in different countries: Barcelona, Berlin, Milan, Budapest, Sofia and Stockholm. Data from half of the cities studied showed: the chance of getting a blood disease among those who use analgin is 23 times greater!

What does the Ministry of Health of Ukraine think about all this? His recommendations for doctors suggest prescribing analgin without special reservations. “Headache, toothache, neuralgia, radiculitis, myositis, pain during menstruation,” advises

Ministry of Health for the 41st year after the WHO call to ban analgin.

What to do if you have pain

Svidomo will not take upon itself the sin of advertising a specific drug. Universal advice for any pain: go to the doctor. Analgin, like many other drugs, is a symptomatic medicine that simply does not allow the pain signal to reach the brain.

In Ukraine, where most pills can be bought without a prescription, which means there is even less incentive to go to the doctor, the situation could be much worse. So you start correcting it from yourself.

Comments from our experts

Tatyana Golofeeva, pharmacist:

Even twenty years ago (), when I studied at the Leningrad Pharmaceutical School, at lectures teachers told us that analgin has a negative effect on the heart. Popularly, this action is called “settling” the heart. This information was etched into my memory from my student days. And I want to note that I don’t have analgin in my medicine cabinet at home. There are many other medications that relieve pain. Nowadays, it is not difficult to find an alternative to the same analgin. For children, the pharmacy where I work has ampouled (that is, in ampoules) analgin and in suppositories. Analgin tablets are not prescribed to children. In pediatrics, the basis of all medications is paracetamol.

I urge all people to be sure to read the instructions for any medication. Namely, information about side effects. After all, if you read about the side effects of analgin, then a whole paragraph is devoted to this. And people often don’t even read the instructions, let alone information about side effects. In any case, you should never prescribe medicine for yourself (and our people like to treat themselves, thinking that they know everything). Only a doctor has the right to prescribe this or that drug. By contacting a doctor, most importantly, you will protect yourself and protect yourself from all sorts of side effects of analgin. And in conclusion, I want to say that it is not recommended to abuse any medicine, and especially analgin.

After reading the material of the articles, I got the impression that the author of these lines did not particularly bother himself with researching this problem, he simply took a ready-made publication, slightly “combed it” and presented it to the public under the guise of a “hot topic”. Akin to fast food - bright packaging, easy to prepare, easy to swallow, easy to digest, but has negative consequences.

I'll try to explain my point of view. If you take a pharmaceutical reference book for doctors, then when describing any medicine, the mechanism of action, recommended courses and doses, area of application (indications), as well as contraindications and possible side effects are indicated. I would like to clarify right away: any medical student studies pharmacology for a year, after which he takes an exam. However, there is also such a discipline - clinical pharmacology, which is a logical continuation of the previous (general) pharmacology. Let's add here special literature on the interaction of drugs and their rational use - any competent doctor always uses such information. However, the final ability to competently use medications is developed at clinical departments under the guidance of practicing specialists.

This raises the question: why are the available drugs used so ineptly? There are several reasons for this: the level of training of specialists, the “information hunger” of practicing doctors, the “venality” of many scientific publications that publish information to please pharmaceutical manufacturers, the “squeezing” of doctors by strict orders and recommendations of higher “scientific” officials, and so on.

Just don’t accuse me of being biased towards pharmacists - I deeply respect their hard work. The problem is different: knowing the “madhouse” going on in clinics, out of compassion they make concessions to customers.

Let's return to the ill-fated analgin. “Scientific” men “exposed” his terrible nature. However, then let's ban aspirin with its tendency to cause stomach ulcers and... development of a dangerous condition - “aspirin” asthma. By the way, 20 years ago, all annotations for this drug indicated a side effect - thrombocytopenia. Nowadays this phenomenon is used by many doctors and is popularly called “blood thinning.”

If a person’s back hurts or their joints are inflamed, we inject and swallow nimids, diclacs, nurofens and other related drugs. At the same time, few people think about the ability of these drugs not only to cause ulcerative processes in the gastrointestinal tract, but also about their aggressive relationship to the liver and kidneys.

They advertise “Gepabene” on TV - you can listen to the nightingales sing! But at the same time they modestly keep silent about the fact that long-term and uncontrolled use of this drug leads to the opposite effect (hepatotoxicity). Such examples can be continued ad infinitum...

Any pharmaceutical drug can have a damaging effect. The point is not that they should be banned indiscriminately, but that they should be able to be used wisely. We won’t ban a kitchen knife just because someone cut their fingers with it.

And one last thing. The articles introduced the concept of “Lyell's syndrome”. Just horror and horror. Only when applying this concept, the author of the articles did not deign to inquire about its essence. So, Lyell's syndrome is a toxic-allergic necroepidermolysis, which develops with the use of sulfonamides, penicillins, tetracyclines, barbiturates, contraceptives, etc.

Health Directory

Subscription

Sections

Notes to the doctor (5)
Eyes (6)
Childhood diseases (11)
Diagnostics (1)
Food (15)
Women's health (9)
Teeth (4)
Ideal weight (3)
Immune system (2)
Leather (5)
Blood (3)
Medicine. Instructions for use (11)
ENT diseases (1)
Medicine and Law (1)
Men's health (6)
Narcology (1)
Traditional medicine (14)
Ambulance (1)
News (25)
Oncology (2)
Digestive organs (3)
Confrontation (6)
Professional hazard (3)
Prevention (14)
Psychology/Psychiatry (1)
Family and health (5)
Heart and blood vessels (4)
Symptoms (1)
Statistics (2)
Trauma (2)

Statistics

Danger and harm of analgin - myth or reality?

The most popular medicine that citizens of our country use to relieve pain is analgin. It is taken absolutely uncontrollably, without a doctor’s prescription, and the availability of analgin is often abused, without thinking about the side effects and harm to the body. Analgin has been completely withdrawn from trade in a number of countries, namely: Italy, Denmark, USA, Great Britain. But nevertheless, in some countries of South America, Asia and Europe (including Ukraine) it continues to be used everywhere.

Analgin (metamizole sodium) is used as a powerful analgesic, antipyretic and antispasmodic agent. It is prescribed for acute pain of medium and low intensity of various origins (biliary, intestinal and renal colic, neuralgia, myalgia, trauma, swelling, headache or toothache, dysmenorrhea, radiculitis, febrile syndrome in inflammatory diseases, etc.)

Side effects from taking analgin are often underestimated, but they exist and are quite serious. Complications include allergic reactions (especially from the urinary and nervous systems), hematological, cardiovascular complications, and local disorders.

When self-medicating, you must carefully read the instructions (insert leaflet) of the drug. The adverse reactions indicated in it are expected, that is, they most likely will not occur if the patient first consults with the attending physician, who will assess whether there is any risk associated with taking the drug.

Metamizole (analgin) for many decades was an emergency drug in our country, and not a means for the treatment of chronic diseases. That's how it should remain.

One of the most serious side effects of analgin, which seriously worries doctors, is associated with a serious blood disease - leukopenia. Long-term use of analgin can negatively affect the number of leukocytes. But the reasons for this phenomenon include reduced immunity and poor ecological environment in the patient’s place of residence. The occurrence of leukopenia is also possible with long-term use of any non-steroidal anti-inflammatory antipyretic drug, such as aspirin or paracetamol. Only you won’t find such a warning in the annotations to the latter!

Recently, a fairly aggressive campaign has been launched against analgin on the Internet. Many domestic experts consider it custom-made and beneficial, first of all, to large manufacturers of new expensive drugs.

In the 60s of the last century, medical circles were shocked by a report from the United States: women taking the drug thalidamide for a number of years led to the birth of several thousand malformed children. WHO has tightened control measures. If even isolated, but serious cases of adverse reactions were recorded in one or two countries, the drug was immediately banned. Nowadays, sufficiently proven drugs are entering the global pharmaceutical market. For example, in the USA, up to one and a half billion dollars are spent annually on the program for their study. However, there is one significant “but”: according to the criteria of the same WHO, the maximum positive and negative effects of a medical drug are revealed from the moment of its mass production and use throughout the years!

The legislation on pharmacotherapy in our country requires tightening. Advertising in the media alone is worth it! Actors in the role of doctors call for taking certain “harmless” medications - isn’t this absurd? In no other European country will you see advertisements for medications on a bus or tram. And here we do it in violation of international and domestic regulations. There have not been, are not, and are not expected to have safe drugs in the foreseeable future.

This entry was posted on Monday, February 7, 2011 at 16:18 in the category Medicine. Instructions for use. You can subscribe to new comments on this article: RSS 2.0. You can leave your comment, or trackback from your site.

4 comments to “Danger and harm of analgin - myth or reality?”

MED.K writes:

I’ve been saying for a long time that it’s time to put an end to this unbridled (and pharmacologist-funded) bacchanalia. In pharmacies, citizens in white coats (who have primary medical education) freely make the most complex diagnoses, without bothering themselves much... I wonder - why do medical institutes maintain medical faculties? If making a diagnosis is so simple.

What is this “allergic reaction from the urinary and nervous systems”? The author may have confused the concept of allergy as a pathological reaction to a foreign agent and the consequences of this reaction on body systems (primarily the cardiovascular in severe cases).

Otherwise, the article is necessary and useful, in my opinion.

The article is stupid, useless and illiterate. For the author, “pain reliever” is obviously derived from the words “bal” and “balit”. For everyone else, in a normal situation, analgin is a pain reliever.

Until when will doctors prescribe medications to a patient without a preliminary examination, but only based on his story about his state of health? Moreover, the list of medications is not on a prescription form, but on a random piece of paper with advertising that has nothing to do with the patient.

Full or partial copying of articles and materials from the Health Directory website is permitted provided there is a link (direct, open to search engines, hyperlink) to the source - http://healthcollection.ru/

What harm is there from analgin if analgin is banned in the West due to harm?

Is analgin harmful?

We traditionally use analgin treatment very widely.

Analgin is considered almost a panacea for all diseases.

But abroad, analgin is not among the widely used drugs, and there is even an opinion that analgin is harmful to human health.

So is there any harm from analgin and what kind of harm?

There are no harmless drugs, and I believe that the harm of analgin is not at all a myth, as many people think. This is not a panacea, and all over the world, including in developed European countries, it was banned for a reason.

Russian pharmaceuticals are one of the last to fight for analgin against the World Health Organization, since it is cheap and effective. It has a large number of side effects; of course, it does not eliminate the cause of pain and is addictive. Many, because of such drugs, bring their disease to the chronic stage, because They do not treat, but simply “drown out” the symptoms.

Many of my friends drink several packs of analgin during menstruation. This is not normal, I think.

Any drug, of course, has its side effects. Why such attacks on analgin. Analgin, like paracetamol, as well as aspirin, is an NSAID, a non-steroidal anti-inflammatory drug. And its side effects are the same as those of aspirin and paracetamol. Only unlike them, it has more breadth of therapeutic action, that is, it is more difficult to overdose. And such drugs as baralgin, spasmalgon, maxigam, revalgin, spasmalin, baralgetas, baral. One of the components of which is metamizole sodium (the international generic name for analgin). Half of these drugs are foreign-made. So where they are fighting it, only in the USA, for the sake of their paracetamol. But paracetamol is toxic and affects the liver. 4 grams of paracetamol and you have cirrhosis. We have been using Analgin for 90 years, in our country it is used in tons, and if it had such side effects, our whole country would have died out.

Of course, it is not a panacea for all diseases. But sometimes there is no drug better than it. As an antispasmodic, it is one of the most effective. As an antipyretic, and much more. Now, of course, it has already been supplanted; radicular pain is better treated with diclofenac. It is supposedly better to reduce the temperature with nurafen (by the way, our ibuprofen) But as an ambulance it cannot be replaced for hepatic and renal colic. Somehow they stopped buying it from us, our bosses, having read articles about it, thought that there was no need to buy it. We had problems, it turns out that it is a good antipyretic. We tried everything and nurofen, and paracetamol, diclofenac. And the patient’s temperature is 40 and nothing helps. We went to the departments and gave 2 am. It’s good to use in moderation and correctly. You don’t need to drink tons of it, but use it strictly according to indications.

if you drank analgin, you probably noticed that the urine is colored, becomes reddish, this is one of the harmful properties of analgin - a negative effect on the kidneys, when taking this drug, various degrees of an allergic reaction are possible, up to Quincke's edema, but the most dangerous is that that analgin affects hematopoiesis, changing the structure of the blood in a bad way.

When used frequently, Analgin is harmful and can even cause severe changes in the blood count. But it should be remembered that other medications are not harmless. For example, paracetamol at a small dosage can become extremely dangerous for the liver and kidneys. Aspirin is contraindicated in childhood.

Analgesics and antipyretics should be taken strictly according to indications and for a short amount of time - one day, maximum three days. If symptoms do not go away, be sure to see a doctor.

It should be remembered that when you have a cold, you should only bring down a sufficiently high temperature. You should not take analgin or paracetamol with a slight increase in temperature.

I was convinced from my own experience that analgin is very harmful to the heart and kidneys, it takes a very long time to be eliminated from the body in the urine, and has no beneficial effect on the blood, including during menstruation. for example, I know real cases when some ladies, going on an intimate date, knowing in advance that a surprise may happen in pastels, i.e. That is, if you go on your period at the most crucial moment for both partners, if you take analgin the day before, or a couple of days before, then your period will not come on time, but there will be a delay of 3-4 days. Out of ignorance, I used to take analgin for headaches and other pains, until one day, without waiting for my period on the due day, I ran to the doctor, thinking that I was pregnant, but it turned out, no, I just delayed my menstruation with analgin, which I never do anymore. I declare with complete confidence that ANALGIN is very HARMFUL, especially for the female body.

Doctors have come to the conclusion that analgin, so familiar to us since childhood, is harmful to health, although small doses of this medicine are still considered not dangerous. The main negative effect of analgin on the body is that it poisons the liver. In addition, with regular use of analgin, a person develops addiction, or even worse - dependence. This is noticeable by the fact that with a headache, after taking the pill, the pain disappears for several hours, but then appears again, requiring another dose of analgin. Scientists have also discovered that analgin in combination with amidopyrine) has a very bad effect on the blood, killing leukocytes in it.

I don’t know if it’s true, but analgin delays the onset of menstruation by 3-4 days if taken for a headache or some other pain, a couple of days before, or on the eve of menstruation. verified by personal experience. Some ladies, if they are going on an intimate date, know what can happen, i.e. unexpectedly for the partner, she has red days, a day or two before them they specially take analgin, thereby delaying the natural process for several days! as well as analgin does not have a beneficial effect on the heart and kidneys, and is excreted from the body in the urine for a long time. When I learned about such side effects, I threw away the entire drug, even though it was not yet expired.

There may be harm from analgin, but one tablet of analgin brings down the temperature to 39.8 in half an hour. But paracetamol up to four tablets does not cope with this. Doctors believe that analgin should be taken no more than three tablets per day and no more than three days at all. It has a negative effect on the kidneys and can lead to allergic dermatitis. If you take analgin for a very long time, you may experience suffocation and a decrease in blood pressure. All medications should be taken in moderation and as recommended by doctors.

In many countries around the world, analgin is generally prohibited for sale as a pure substance.

And it’s not for nothing that such a restriction was introduced. Analgin is harmful to the body.

1.Severely affects the kidneys. 10% of people attending hemodialysis procedures have abused analgin in the past.

2. This drug significantly inhibits the hematopoietic function of the bone marrow. Immunity is greatly reduced, because the bone marrow produces our body's defense - leukocytes.

And other analgesics are not a “gift” for health. They only drown out the pain, leaving the problem of its occurrence unresolved.

Numerous studies have proven that excessive use of analgin leads to kidney failure. Analgin is also capable of suppressing bone marrow tissue in large quantities, thus limiting the production of leukocytes, which leads to poor resistance of the body to infections.

And analgin can also be addictive. And your head will hurt for no reason, requiring you to take analgin again.

Analgin, like every medicine, has a whole list of side effects, where without them. For analgin, this is an allergic reaction, impaired renal function, red coloration of urine, disruption of the functioning of the hematopoietic organs, and decreased blood pressure.

By the way, this applies not only to analgin, but to all medications based on metamizole sodium. For example, baralgin, optalgin and others.

Analgesics cause blood cancer. The oldest and most popular remedy (banned in Europe and replaced by ibuprofen).

It should be noted that many painkillers are complex, so they can simultaneously affect several aspects. I prefer tempalgin based on analgin.

When taking analgin, leukopenia is possible. This is a blood disease associated with a lack of white blood cells. Other side effects are also possible: allergic reactions, hematological, cardiovascular complications, local disorders.

and I’ve heard for a long time that analgin affects the heart, and since I very rarely take pills, if necessary, for general pain I still use baralgin, and if I have a headache, then citromon

Is there any harm from analgin?

Analgin is the most common painkiller in our country. This is explained by the fact that the medicine is cheap and is sold without a doctor's prescription. Many people take algin for any pain, without thinking at all about the possible consequences. But few people can say for sure whether analgin is harmful. The harm from this medication can indeed be considerable.

General characteristics of the drug

Analgin is a non-narcotic analgesic of artificial origin. The active ingredient is metamizole sodium. This drug has antipyretic, antispasmodic and analgesic effects. Most often the medicine is taken for:

persistent migraines;
toothache as first aid before visiting a doctor;
periodic pain in women;
colic in the kidneys or intestines;
neuralgia;
pain after injury;
postoperative period;
decrease in body temperature.

People often start taking analgin without consulting a doctor. At the same time, few people are interested in the instructions for this drug, contraindications and possible side effects. And it’s completely in vain, this painkiller is considered quite strong and, if taken uncontrolled, can cause serious harm to health.

If you have menstrual pain, it is advisable not to get carried away with analgin. It is better to take a no-shpa tablet, which will relieve the spasm.

Contraindications for use

The anesthetic has a number of contraindications that cannot be ignored. These include:

individual intolerance to the components included in the medicine;
bronchial asthma, especially in the acute stage;
chronic liver and kidney diseases;
blood diseases.

Side effects

We should not forget about the possible side effects that may occur if a person uses pills uncontrollably. The following conditions may develop:

Allergic skin rashes.
Quincke's edema.
Anaphylactic shock.
Exudative erythema.

Side effects may occur even if the therapeutic dosage is observed if a person is hypersensitive.

If your health condition worsens during treatment with analgin, stop taking the drug immediately.

What is the danger of analgin

Metamizole sodium can be truly dangerous if taken regularly and unsupervised. Doctors say that you can only drink 2 analgin tablets a day. In this case, it is advisable to use the drug only as first aid, and then switch to more gentle medications. It is better not to use this pain reliever for the treatment of chronic diseases.

If you take this drug for a long time, the following dangerous conditions may occur:

The number of leukocytes in the blood decreases.
The functioning of the cardiovascular system is disrupted.
The functioning of the nervous system is disrupted.
Attacks of suffocation are observed.
Blood pressure decreases.
Thrombocytopenia is observed.

In addition, immunity steadily decreases, a person becomes seriously ill for a long time.

Analgin can be addictive. This is manifested by the fact that after taking the pill it becomes easier for only an hour, then the pain manifests itself with renewed vigor. So the body requires a new dose of medication.

What happens if you drink a lot of analgin and often

If a person drinks 5-6 tablets of sodium metamizole per day, this will ultimately affect his health. The person will periodically experience nausea, vomiting, shortness of breath, tachycardia and abnormal drowsiness. In severe cases, fainting, seizures, tinnitus and kidney failure may occur.

With a significant overdose of analgin, paralysis of the muscles of the respiratory organs can develop, which will lead to suffocation.

Do not forget that analgin has a very bad effect on the kidneys. Thus, according to statistics, about 10% of patients with renal failure acquired this disease due to long-term use of an analgesic.

Leukopenia

Analgin can lead to the development of a life-threatening disease such as leukopenia. In this case, the production of leukocytes, which protect a person from inflammatory processes, decreases. A particular health hazard is posed by the combination of two medications - analgin and amidopyrine, which ten years ago emergency doctors injected unfortunate patients with high fever. These two medications together almost completely kill white blood cells.

The lethal dose of analgin for humans is grams.

The benefits and harms of analgin are almost equivalent, and they depend only on the person who takes this medication. If you take the medicine as prescribed by your doctor and take into account contraindications, it will not cause harm to your health.

Support our project on social media. networks!

Write what you think Cancel reply

All information on the website otravlenye.ru is intended for informational purposes only and does not constitute instructions for action.

For medical assistance, we strongly recommend that you consult a doctor.

Analgin is one of the most common and popular drugs. It belongs to the clinical and pharmacological group of pyrazolones - drugs with analgesic and antipyretic properties.

Active component and release forms

The active component of the drug is metamizole sodium. Additional ingredients in the manufacture of tablet forms include sodium lauryl sulfate, potato starch, calcium stearate and talc.

This drug is supplied in the form of oral administration (500 mg tablets), as well as in the form of a 25% and 50% solution for parenteral administration in ampoules of 1 and 2 ml.

Properties and pharmacokinetics

Analgin is able to reduce the intensity of pain and lower body temperature during a febrile reaction (due to increased heat transfer). It has an anti-inflammatory effect due to the inhibition of COX and prostaglandins.

After entering the gastrointestinal tract, the active substance is absorbed quickly and almost completely. The effect develops ½-1 hour after consuming the tablets, and on average 30 minutes after injection. Hydrolysis of metamizole sodium occurs in the intestinal wall, and the metabolites undergo biotransformation in the liver. The level of their conjugation with serum proteins reaches 60%. Metabolic products leave the body with urine.

When should you take Analgin?

Indications for the use of Analgin are:

Analgin: contraindications

Analgin is not prescribed if the patient has individual hypersensitivity to metamizole sodium, additional substances included in the drug or pyrazolone derivatives.

Other contraindications include:

pregnancy I and III trimesters;
children's age (under 10 years);
intolerance to NSAIDs;
"aspirin asthma";
acute pain in the abdominal area (until the cause is established);
pathologies of the hematopoietic system;
bone marrow dysfunction (in particular after a course of cytostatics);
acute intermittent porphyria (with blood pressure<100 мм рт. ст.).

Important:Analgin should be prescribed with extreme caution to persons with chronic alcoholism and kidney pathologies.

It is advisable for patients to take the smallest effective dose, that is, the amount of the drug that reduces pain and reduces fever. The dosage is determined by the intensity of pain and fever, as well as relative contraindications.

The tablets should be swallowed without chewing and washed down with a sufficient amount of clean water. They should be taken after meals.

For adolescents under 14 years of age, a single dose is determined at the rate of 8-16 mg/1 kg of weight (for fever, 10 mg/kg is given). For adolescents over 15 years of age, as well as for adults (weighing more than 53 kg), the permissible single dose is 1000 mg (2 tablets).

The permissible daily dose for adolescents (from 32 to 53 kg) is up to 4 tablets, and for adults – 8 tablets.

For elderly and senile people, the daily volume should be reduced, since their excretion of metabolites is somewhat slower. The same tactics are followed if the patient has reduced functional activity of the kidneys.

Important:Long-term use is unacceptable against the background of liver failure.

The total duration of treatment depends on the nature of the disease and the severity of clinical symptoms. If long-term use is necessary, monitoring of the blood picture is required.

Indications for injection of the solution are intense pain of various origins. Dosage for adults – 1-2 ml 2-3 times a day (but not more than 2 g per day). For children over 10 years of age and adolescents, the dose for parenteral administration is determined at the rate of 0.1-0.2 ml of 50% or 0.2-0.4 ml of 25% solution for every 10 kg of weight.

Side effects of Analgin

Metamizole sodium can cause the following adverse reactions:

(more often - skin rashes and itching, less often - and);
changes in the blood (in rare cases, leukopenia, thrombocytopenia and agranulocytosis are noted);
acute decrease in the functional activity of the kidneys;
red coloration of urine.

Important:clinical signs of agranulocytosis are hyperthermia, inflammation in the oral cavity and genital area.

If there is any deterioration in the patient's condition, even before obtaining laboratory test data, taking metamizole sodium should be stopped immediately.

Interaction with other drugs

Analgin can enhance the effect of ethyl alcohol, so it does not need to be taken together with pharmaceutical or homemade medicinal tinctures.

When combined with Chlorpromazine, a significant decrease in body temperature is possible.

You cannot take penicillins, radiopaque compounds and colloidal blood substitutes at the same time.

Metamizole sodium tends to reduce the plasma concentration of Cyclosporine.

Analgin increases the therapeutic activity of Indomethacin, glucocorticosteroid hormones and indirect anticoagulants, since it prevents their conjugation with blood proteins.

When taken in parallel, barbiturates reduce the effectiveness of Analgin, while codeine and drugs increase it.

Oral contraceptive pills, Allopurinol and tricyclics can increase the toxicity of metamizole sodium.

Overdose

a sharp decrease in body temperature;
(significant drop in blood pressure);
general weakness;
cardiopalmus;
confusion;
respiratory muscle paralysis;
development of acute liver and (or) symptoms.

In case of overdose, it is necessary to induce vomiting in the victim and perform gastric lavage using a tube. For binding and accelerated excretion of the active substance, () and salt are indicated. In severe cases, it is necessary to take immediate measures to maintain vital functions. Forced diuresis, hardware blood purification through hemodialysis, and administration of drugs to alkalize the blood are prescribed. The development of seizures is an indication for intravenous injections of fast-acting barbiturates and Diazepam.

For whom is Analgin especially dangerous?

The likelihood of developing severe hypersensitivity reactions is higher in patients with the following pathologies:

hypersensitivity to NSAIDs (asthmatic or allergic reaction);
ethanol intolerance;
intolerance to benzoates (common preservatives).

Give with caution to victims with multiple traumatic tissue injuries. Close monitoring of hemodynamic characteristics is necessary if the patient is diagnosed with acute pathologies of the heart and blood vessels (in particular -) or arterial hypotension. There is a high risk of complications from drug therapy with this drug in people suffering from dehydration.

Important:if an “acute abdomen” is diagnosed, metamizole sodium, as well as other analgesics, should not be given in order to avoid “blurring” the symptoms.

There is no data on the likelihood of the formation of fetal malformations under the influence of Analgin. Due to a lack of information, women preparing to become mothers are strongly advised to refrain from using the drug in the early and late stages. Since metamizole sodium partially blocks the production of prostaglandins, there is a possibility of early closure of the ductus arteriosus in the unborn child.

Analgin's metabolic products can pass into mother's milk, so this medicine should not be taken by women during lactation. As a last resort, you can feed the baby no earlier than 2 days after administration.

Analgin is the most affordable medicine that can be bought in pharmacies. It is used to relieve pain in teeth, headaches, and other types of pain. However, few people thought about the side effects of analgin. But they exist, and they are very serious.

Generally speaking, analgin is not recommended for oral use for a long time. Health officials should be concerned about the availability of this drug. Indeed, analgin is inexpensive and accessible to absolutely everyone, both children and adults. In many countries, such as Italy, Great Britain, and the USA, there has been a ban on analgin for a long time.

The fact is that this drug acts on the human body like a drug, that is, dependence on analgin appears. You have probably noticed for a long time that after using analgin the headache subsides, but after a while it is felt again. This is a clear sign that the first signs of addiction are already observed.

The most correct use of analgin is its use as an antipyretic. And for headaches there are other drugs that work no worse than analgin. In addition to dependence on analgin, there are other side effects. These include, for example, harmful effects on the blood. The use of analgin in large quantities and for a long time leads to a decrease in leukocytes in human blood. This is scientifically proven.

The substances that make up analgin kill leukocytes. In addition, there is a very high risk of giving yourself a liver transplant. Analgin also has a detrimental effect on our immunity. It’s easy to guess what will happen next, the immune system weakens, and then everything is clear without words.

Another well-known drug, citramon, has exactly the same side effects. As already written above, these 2 drugs are just painkillers. But when something hurts us, we don’t think about anything. The best option is to use it once and consult a doctor. And for headaches, take other tablets, which are harmless alternatives to analgin and citramon.

It’s even better to be treated with folk remedies. They are definitely harmless. Follow a sleep and rest schedule, rest well, don’t worry about trifles, don’t quarrel, don’t swear - and you won’t have a headache. If you contact the dentist on time, you will not have problems with your teeth, and, therefore, there will be no pain. This means you won’t need either analgin or citramon.

No medicine is completely safe; even the most harmless in large dosages can cause toxic reactions. Many drugs have long since become a thing of the past, and each of them represents a milestone in the history of pharmacology. In Russia, some medicines are still used, which the entire civilized world has long abandoned as scientifically outdated and toxic.

Analgin is prohibited for use in 40 countries of the world, but in our country it is used independently and as part of combined painkillers.

Panacea for pain

Analgin was synthesized a long time ago. Back in 1920, during the search for a readily soluble form of amidopyrine. It was used as an affordable pain reliever, since there was no wide range of pain relievers at that time. Of course, narcotic analgesics were used, but the medicine of that time already had sufficient data on drug addiction, and this group of drugs was used only in appropriate cases.

Analgin has become a universal pain reliever with sufficient effectiveness. In fact, the very name of the drug speaks of “no pain.” Compared to modern analgesics, metamizole sodium (this is the chemical name of analgin) is at the very end of the list in terms of its analgesic effect, but this does not prevent it from being included in a dozen combined painkillers.

Analgin belongs to the group of non-steroidal anti-inflammatory drugs, or NSAIDs, the most common and most frequently replenished group of drugs. This drug has almost no anti-inflammatory activity, unlike, for example, aspirin. But it has a pronounced analgesic effect and also has antispasmodic activity, that is, it is able to eliminate muscle spasms.

Until recently, it was used as an antipyretic, even in pediatric practice, since this effect is also present in analgin.

With the advent of faster-acting and safer drugs, for example, paracetamol, doctors began to gradually abandon the use of analgin. This is surprising, but there are many doctors who work “the old fashioned way” and do not recognize modern methods of treating pain. It would seem that doctors should take care of the health of children first of all, but the results of some medical studies are amazing.

Despite the recommendations of the Pharmacological Committee of Russia, about 20% of pediatricians recommend analgin to relieve fever and relieve pain in children! At the same time, modern recommendations contain instructions about the inadmissibility of using analgin before the age of 18.

Analgin is a legally prohibited drug in many countries. In Australia and the UK it has not been applied since 1965, in the USA - since 1977, in Italy - since 1979, in Germany - since 1987, in Spain - since 1989. The list of countries goes on, and it includes not only economically developed countries, but also many developing ones - the Philippines, Bangladesh, Pakistan, Peru, Singapore.

Fairness of the accusations

What is this historical drug accused of? The reason for all the attacks is the proven possibility of very serious adverse reactions, primarily dysfunction of hematopoiesis. Doctors assess the possibility of such a reaction as very high, even with occasional use of analgin.

Allergic reactions in the form of such a serious complication as anaphylactic shock are observed with the same frequency as inhibition of hematopoiesis. If you add to these side effects a very real threat to the stomach, kidneys, and liver, the danger of use becomes obvious.

In Russia, analgin continues to be produced by many manufacturers and is sold uncontrolled in all pharmacies, that is, without a prescription and a corresponding warning in the annotation. According to medical statistics, analgin is the most popular painkiller in Russia. What is the reason for such amazing fame? The answer is simple.

Analgin has been known for almost 90 years, in the minds of many people it is “a proven remedy that my grandmother used to treat,” its price is extremely low, no prescription is needed to purchase at a pharmacy, and there is widespread misconception about its safety.

To be fair, it must be added that there are many other outdated drugs that have no less serious and dangerous consequences for human health, but are still used for various reasons. But it was analgin that suffered the fate of the first “persecuted” drug.

Against the background of such data, I would like to advise you to carefully read the instructions and not to use any medications unless absolutely necessary. Who knows, maybe in a few decades scientists will discover dangerous side effects of relatively harmless modern medications?

About self-medication

Every day in the world, about 300 million (!) people use one or another painkiller, two thirds of them prescribe treatment for themselves. There are a lot of painful conditions when pain indicates physiological (natural) and quickly passing disorders in the body. There is nothing wrong with a person knowing exactly what medicine to take to get rid of pain.

But all painkillers do not act on the cause of the pain, they only help cope with it, if we speak in medical language - they are symptomatic remedies. Therefore, you need to be extremely careful when it comes to chronic pain. Conventional analgesics may not help, but only harm! This is especially true for “psychogenic” pain, which occurs for no apparent reason against the background of emotional disorders.

Many years ago, analgin took pride of place in all first-aid kits in our country. With a habitual gesture, as soon as something hurts, people immediately grab an analgin tablet, or even two at once - for guarantee. It’s quite clear where this fame comes from: the drug relieves pain well, is inexpensive, and can be bought at any pharmacy.

Therefore, the news that analgin is banned in some countries is puzzling. What could be dangerous about it? Why can't you drink analgin? Europeans or Americans, are they different from us?

Let's try to figure it out.

Analgin and self-medication

The first pitfall lies in treating everything with the same pills at once. Analgin is taken as an analgesic, antipyretic, “for teeth”, “for head”, “for joints”. Doses are prescribed to yourself: why not take three instead of one tablet? It can't get any worse!

We must not forget that this remedy only relieves pain, but does not treat the cause of the disease. The action of analgin is that it puts a “block” on the path of pain signals, which usually come from nerve receptors to the brain. Thanks to the drug, transmission is blocked, and the brain either does not perceive pain at all or perceives it muffled.

Constant use of analgin can force the patient to give up on real treatment, and the disease will develop uncontrollably, with unpredictable consequences.

The second danger that awaits “self-healers” is the risk of overdoing the dose. Next we will talk about the toxicity of analgin itself, and what a person can expect in case of an overdose.

Why you can’t drink analgin uncontrollably

Firstly, an overdose of analgin negatively affects the liver. Therefore, if you have any illnesses associated with it, or if you are at risk of developing liver failure, it is better to refrain from taking this drug. It is worth paying attention to the kidneys - if they are not in order. Then you should take anything, including analgin, only after consulting a doctor.

Secondly - and this is the main reason that analgin is looked at askance - the hematopoietic system may suffer. An overdose of metamizole sodium (the so-called active ingredient of analgin) can cause a decrease in the level of leukocytes, platelets and granulocytes in the blood.

Agranulocytosis is the same disease due to which our favorite pills are banned in Australia, the USA, and many European countries. Because of it, immunity sharply decreases, and this entails serious consequences, including the death of the patient.

When platelet levels drop, blood clotting decreases. Severe internal bleeding may occur, and mechanical injuries cause hemorrhages and hematomas.

Intoxication with analgin also affects the respiratory system: the mucous membrane of the trachea and bronchi becomes inflamed, the larynx suffers, and ulcers form in the mouth.

To whom is analgin contraindicated?

Analgin should never be taken by people from one of the following groups:

children under ten years of age;
pregnant women (this drug is especially dangerous in the first and third trimester);
nursing mothers - penetrating into milk, analgin can harm the baby;
persons suffering from hemophilia and other pathologies of the hematopoietic system;
persons with bone marrow dysfunction;
patients with porphyria;
persons with individual intolerance to the components of the drug.

With all that, analgin is not a poison, but a good remedy. Which successfully copes with its main role - pain relief. It is only harmful to take analgin without permission, without consulting a doctor.

It is always worth remembering that even the best medicine is not a magic wand that cures all diseases. And before you drown out the pain, you need to determine where it came from. With proper treatment, analgin will help make life calmer and more comfortable.