Vitamins Aevit (capsules, injections) – instructions for use, analogues, reviews, price

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Aevit is a combination drug containing high dosages vitamins A and E. Aevit normalizes metabolism, neutralizes the harmful effects of free radicals (due to the powerful antioxidant effect of vitamin E), restores blood microcirculation through the capillaries, and also significantly improves tissue resistance to oxygen deficiency.

The vitamin preparation is used in the complex treatment of vascular atherosclerosis, obliterating endarteritis, as well as various nutritional disorders of peripheral tissues (for example, against the background of diabetes mellitus, microcirculation failure, thrombosis, etc.). In addition, Aevit is used to eliminate hypovitaminosis or vitamin deficiency of vitamins A and E. Since the drug contains high dosages of vitamins A and E, it is not intended for prophylactic use (it is used only for treatment).

Release forms and composition of Aevit

Currently, Aevit is available in two dosage forms:
1. Gelatin-coated capsules for oral administration;
2. Oil solution in ampoules for intramuscular injection.

Aevit capsules are available in round or oval shape. Regardless of the shape, the capsules are soft, covered with a gelatin shell, colored in various shades from dark yellow to light brown. The shell must be uniform over the entire surface, without any smudges or contamination. Inside the capsules there is an oily, slightly viscous liquid, colored in various shades of yellow. Capsules are available in packs of 25 and 50 pieces.

The oil solution for intramuscular injection is available in hermetically sealed 1 ml ampoules. The solution is an oily, slightly viscous liquid, light or dark yellow in color. The solution for injection is available in packages of 10 ampoules of 1 ml.

As active ingredients, the injection solution and capsules contain vitamin A in the shape of retinol palmitate And vitamin E as alpha tocopherol acetate. Each capsule contains 100,000 IU of vitamin A and 100 mg of vitamin E. One milliliter of oil solution contains 100 mg of vitamin E and 35 mg of vitamin A (approximately 38,000 IU).

The solution for intramuscular injection as an excipient contains only any vegetable oil - corn, first grade hydrated soybean or refined sunflower, in which vitamins A and E are dissolved. The contents of the capsules are exactly the same oil solution, which, unlike the form for injection, not sterile and enclosed not in an ampoule, but in a gelatin shell. That is why capsules as auxiliary components, as well as an oil solution for injection, contain some type of vegetable oil - corn, soybean or sunflower.

In addition to vegetable oil, auxiliary components in the capsules also include substances used for the production of the gelatin shell, such as:

• Gelatin;
• Glycerol;
• Nipagin;
• Nipazole;
• Red dye;
• Quinoline yellow;
• Shiny blue;

Therapeutic effects of Aevit

The therapeutic effects of Aevit are due to the high dosages of vitamins A and E included in its composition.

Vitamin A ensures normal vision at dusk or in low light conditions, since it is part of the visual pigments of the retina. With a severe deficiency of vitamin A, a person develops so-called night blindness, the characteristic feature of which is poor vision precisely in low light conditions. Besides, vitamin A takes part in the following processes in the human body:

• Ensuring normal bone growth;
• Maintaining the functioning of the genital organs and preserving fertility (vitamin A is necessary for the formation of full-fledged sperm and maturation of eggs);
• Development of the embryo and placenta during pregnancy;
• Accelerates the process of formation of epithelial cells, thereby rejuvenating the cell population of the upper layer of the skin, reducing the rate of keratinization and keeping the skin elastic, elastic and smooth;
• Maintains the integrity of the epithelium of any location.

The properties of vitamin E have not yet been fully studied. However, the available data allow us to conclude that vitamin E is a powerful antioxidant and has the following effects on organs and tissues:

• Supports the process of protein synthesis;
• Normalizes the process of formation of new cells of various organs and tissues to replace old or damaged ones;
• Takes part in the process of tissue respiration;
• Stabilizes cell membranes;
• Increases the resistance of red blood cells to damage, thereby preventing their destruction under the influence of various factors;
• Reduces capillary permeability, preventing edema;
• Reduces capillary fragility, thereby reducing bleeding and the tendency to form bruises and minor hemorrhages on the skin;
• Increases tissue resistance to oxygen deficiency;
• Normalizes fat metabolism;
• Prevents spontaneous miscarriage (eliminates the threat of miscarriage);
• Normalizes the functioning of the male sex glands (testicles, prostate, etc.);
• Helps restore the muscle layer in dystrophies and other muscle diseases;
• Normalizes metabolism in the myocardium in cardiovascular diseases;
• Accelerates blood flow in small vessels.

Thus, Aevit improves the condition of blood vessels and skin, as well as the functioning of the gonads in men and women. The drug restores blood microcirculation through the capillaries, thereby normalizing breathing and tissue nutrition, as well as increasing their resistance to oxygen starvation.

That is why the drug is used in the treatment of vascular diseases and for disorders of the nutrition of peripheral tissues (for example, atherosclerosis, endarteritis, trophic ulcers, numbness in the extremities, bleeding and small hemorrhages under the skin, etc.).

Why take Aevit (indications for use)

Aevita capsules and injections are indicated for use for the following conditions or diseases:
1. Vascular atherosclerosis (obliterating);
2. Obliterating endarteritis stages I, II and III, including those complicated by trophic disorders;
3. Increased mental or physical stress;
4. Period of stress;
5. The period of recovery or rehabilitation after a long or serious illness;
6. Asthenic conditions of any origin;
7. Peripheral neuropathy;
8. Necrotizing myopathy;
9. Abetalipoproteinemia;
10. Tissue nutritional disorders;
11. Hypovitaminosis or vitamin deficiency of vitamins A and E;
12. Conditions of increased body need for vitamins A and E, such as:

• Condition after removal of the stomach;
• Diarrhea;
• Steatorrhea;
• Malabsorption syndrome;
• Chronic cholestasis;
• Biliary atresia;
• Obstructive jaundice;
• Tropical sprue;
• Any infectious diseases, including frequent colds;
• Hemeralopia (night blindness);
• Xerophthalmia;
• Keratomalacia;
• Poor nutrition;
• Drug, alcohol and tobacco abuse;
• Hyperthyroidism;
• A diet rich in omega-3 and omega-6 fatty acids;
• Taking Kolestyramine, Colestipol, mineral oils, Neomycin, or iron-containing products.

Instructions for use

Application of Aevit capsules

Capsules should be swallowed whole, without chewing, biting or opening in any other way, but with a small amount of water (1/4 cup is enough). Capsules are taken regardless of food intake at any time of the day, so Aevit can be taken at the most convenient time for a particular person.

Regardless of the severity of the condition, Aevit must be taken one capsule once a day for 20 to 40 days. Moreover, taking capsules for 30–40 days is recommended only for obliterating endarteritis and nutritional disorders of peripheral tissues, and for all other conditions and diseases, a course of therapy lasting 20–30 days is optimal.

If you need to get a therapeutic effect in a short time, then Aevit can be taken 1 - 2 capsules 2 - 3 times a day for 10 - 14 days.

Courses of therapy with Aevit can be repeated, maintaining intervals between them of 3–6 months. Moreover, an interval of 3–6 months between repeated courses of therapy must be maintained in all cases, regardless of the regimen used (1 capsule per day for 20–40 days or 3–6 capsules per day for 10–14 days).

Application of Aevit oil solution

Aevita solution for any conditions and diseases is administered intramuscularly once a day, 1 ml (1 ampoule) for 20 - 40 days. Repeated courses of therapy are carried out every 3 to 6 months if necessary.

The oil solution is administered only intramuscularly. Injections should be made carefully to prevent the solution from entering the subcutaneous fat layer, skin structures or veins, as this can cause complications.

The need to administer the Aevit oil solution intramuscularly is due to the fact that, firstly, with such use the risk of an allergic reaction is minimal, and secondly, the drug creates a small depot in the muscles, from which it penetrates well into the systemic bloodstream. In the muscle layer, the oil solution is quickly absorbed, since it has an extensive, dense and well-developed network of blood vessels, as a result of which no traces remain of it in a short time after the injection. And in the subcutaneous fat layer or in the skin structures there is not such a number of blood vessels, as a result of which the oil solution remains in the thickness of the tissue for a long time, forming painful seals that can become inflamed and painful. If an oil solution gets into a vein, acute inflammation of the vessel wall or a severe allergic reaction may develop.

Intramuscular injections of Aevit oil solution are performed according to general rules. That is, first the injection site is wiped with a cotton swab moistened with an antiseptic (alcohol, Chlorhexidine, Belasept, etc.), then the ampoule is opened and the solution is drawn into a sterile disposable syringe. The syringe is turned over with the needle up and the wall is tapped with a finger in the direction from the piston to the needle holder so that air bubbles rise up to the surface of the solution. Then, by pressing the plunger, a few drops of the solution are released from the syringe along with air bubbles. After this, the needle is inserted deep into the muscle, holding it at a right angle to the injection site. Then slowly release the solution into the tissue, remove the needle and again treat the injection site with a cotton swab moistened with an antiseptic.

Before administration, the Aevita oil solution must be warmed to body temperature (up to 36 - 37 o C). This can be done by holding the ampoule tightly in your fist and holding it this way for several minutes.

The injection site must be selected in advance, determining where the muscle layer comes closest to the surface of the skin. The optimal areas for intramuscular injections are the following parts of the body:

• The upper third of the outer part of the shoulder;
• The upper third of the anterior outer part of the thigh;
• The anterior upper (above the navel) surface of the abdomen (only for non-obese people);
• Upper outer quarter of the buttock (only for people who are not overweight).

The optimal areas for intramuscular injections are the shoulder and thigh, since in these parts of the body the muscles come close to the skin even in obese people and, accordingly, the risk of the solution getting into the subcutaneous fatty tissue is minimal.

special instructions

In elderly people (over 65 years of age), Aevit in the form of capsules and intramuscular injections should be used with caution and under close supervision by the attending physician.

Aevit should not be taken in dosages exceeding the recommended ones, as this may lead to acute or chronic overdose, which requires treatment. In addition, in order to avoid an overdose of vitamins A and E, you should not take Aevit simultaneously with other multivitamin complexes.

When deciding to use Aevita in any dosage form, you should remember that the drug contains very high dosages of vitamin A, which are intended exclusively for treatment and not for prevention. Remember that Aevit is not a preventive vitamin complex, like, for example, Vitrum, Centrum, etc.

If you follow a diet high in selenium, you should reduce the dosage of Aevit by 1/3 or even 1/2, since this microelement reduces the body's need for vitamin E.

Vitamin A in high doses has a teratogenic effect (causes fetal deformities), which persists for several months after its withdrawal. Therefore, it is recommended to plan pregnancy no earlier than 6 to 12 months after stopping Aevita. Also, before starting to take Aevita, women need to make sure that they are not pregnant, since the drug can cause fetal deformities.

Aevit in the form of capsules and intramuscular injections should be use with caution if a person has the following diseases or conditions:

• Decompensated heart failure;
• Acute or chronic nephritis;
• Cholelithiasis;
• Cirrhosis of the liver;
• Viral hepatitis;
• Chronic pancreatitis;
• Thyrotoxicosis;
• Breastfeeding period;
• Alcoholism;
• Hypoprothrombinemia (low levels of prothrombin in the blood).

Use during pregnancy and breastfeeding

Aevit should not be taken during the entire first trimester of pregnancy (until the end of the 13th week of gestation) due to the high risk of developing fetal deformities. In the second and third trimesters of pregnancy, the drug can be taken with caution and only if it is truly necessary for medical reasons.

Aevit should not be used in the form of capsules or intramuscular injections during pregnancy as a prophylactic agent to prevent possible vitamin deficiency, since the drug contains very high doses of vitamins A and E, intended strictly for treatment.

Overdose

An overdose of Aevit is possible. There are three forms of overdose with Aevit:

• Acute overdose of vitamin A (develops 6 hours after administration of the drug);
• Chronic overdose of vitamin A (develops with long-term use of the drug);
• Acute overdose of vitamin E (develops soon after administration of the drug).

Acute overdose of vitamin A manifests itself in adults with the following symptoms:

• Lethargy;
• Diplopia (double vision);
• Excitement;
• Confusion;
• Nausea;
• Persistent severe vomiting;
• Diarrhea;
• Dryness and formation of ulcers on the oral mucosa;
• Peeling lips;
• Peeling of the skin (especially on the palms).

Chronic overdose of vitamin A

• Bone pain;
• Cracks and dryness of skin and lips;
• Dryness of the oral mucosa;
• Pain in the stomach (gastralgia);
• Vomit;
• Increased body temperature (hyperthermia);
• Headache;
• Photosensitivity (sensitivity to sunlight);
• Pollakiuria (frequent urination);
• Nocturia (urination mainly at night);
• Polyuria (large amounts of urine - more than 2 liters per day);
• Irritability;
• Hair loss;
• Yellow-orange spots on the skin of the palms, soles and nasolabial triangle;
• Increased intraocular pressure;
• Oligomenorrhea (scanty menstruation);
• Portal hypertension (increased pressure in the hepatic portal vein system);
• Hemolytic anemia;
• Changes in bone structure visible on x-rays;
• Teratogenic effect on the fetus (malformations of the urinary system, growth retardation, early closure of bone growth zones).

Acute overdose of vitamin E manifests itself with the following symptoms:

• Blurred vision;
• Dizziness;
• Headache;
• Nausea;
• Pain in the stomach (gastralgia);
• Asthenia;
• High risk of bleeding;
• Disorders of thyroid hormone metabolism;
• Sexual function disorder;
• Thromboembolism;
• Necrotizing colitis;
• Hepatomegaly (enlarged liver);
• Hyperbilirubinemia (increased concentration of bilirubin in the blood);
• Kidney failure;
• Retinal hemorrhages;
• Hemorrhagic stroke;
• Hemolysis (destruction of red blood cells).

Treatment of all three types of overdose with Aevit carried out the same way. First of all, the drug is discontinued, then mannitol, glucocorticoid hormones and Vikasol are prescribed. Mannitol is necessary to reduce intracranial pressure and relieve dizziness, headaches, nausea and vomiting. Glucocorticoid hormones are necessary to accelerate the elimination of excess vitamins A and E. Vikasol is necessary to reduce the risk of bleeding and hemorrhage. Mannitol, Vikasol and glucocorticoid hormones must be taken until the condition normalizes. Additionally, symptomatic therapy can be carried out, aimed at maintaining the normal functioning of vital organs and systems.

Impact on the ability to operate machinery

Aevit usually does not impair the ability to control mechanisms, since it does not affect the functioning of the central nervous system. However, while taking Aevit, you must be careful when working with machinery and when performing any activities that require increased concentration and reaction speed, since the vitamin can cause discomfort in the stomach, which, naturally, will negatively affect the ability to control your actions.

Interaction with other drugs

When taken with the following drugs, Aevit may cause the following negative effects:

• With estrogens (including combined oral contraceptives) and Isotretinoin, the risk of vitamin A overdose increases;
• With calcium supplements, the risk of developing hypercalcemia (increased levels of calcium in the blood) increases;
• With tetracycline antibiotics, the risk of increased intracranial pressure increases;
• With preparations of gold, silver, anticoagulants (Warfarin, Dicumarin, etc.) - the risk of bleeding increases;
• With Kolestramin, Colestipol, Neomycin and mineral oils - the absorption and assimilation of vitamins A and E is reduced (therefore, an increase in the dose of Aevit may be necessary to obtain the necessary therapeutic effect).

Aevit reduces the severity of the anti-inflammatory effect of glucocorticoid hormones, and also reduces the effect of calcium supplements.

Aevit enhances the effect of the following medications:

• Drugs for the treatment of epilepsy (Lamotrigine, etc.);
• Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, Ketorol, Ibuprofen, Nimesulide, etc.;
• Vitamin D;
• Cardiac glycosides (Strophanthin, Korglykon, etc.).

The effectiveness of Aevit is reduced when taken simultaneously with alcohol or medications containing ethyl alcohol.

Taking high doses of iron increases the body's need for vitamin E.

Use of Aevit for various purposes (off-label)

Aevit for face

Aevit vitamins are often prescribed by cosmetologists to eliminate a number of facial skin problems. Vitamin E, which is part of the drug, normalizes the process of production of sex hormones, which, of course, has a positive effect on the condition of the skin not only of the face, but also of the entire body, since with a sufficient amount and optimal balance of estrogens, progesterone and testosterone in the body, the skin becomes fresh, healthy and fit. And vitamin A, which is part of Aevita, normalizes the functioning and regeneration processes of epithelial cells, which eliminates dryness, peeling and inflammation of the skin.

Thus, Aevit has a positive effect on the skin not only of the face, but also of the entire body, eliminating inflammatory elements (pimples, blackheads, etc.) and at the same time giving it firmness, elasticity, freshness and a healthy color. In addition, Aevit slows down the aging process of the skin and effectively eliminates fine wrinkles.

In general, Aevit has the following effects on the skin:

• Normalizes the metabolic process in the skin;
• Improves the process of skin cell regeneration;
• Improves tissue resistance to oxygen starvation;
• Prevents dehydration;
• Suppresses the proliferation of pathogenic viruses and bacteria on the surface of the skin;
• Protects the skin from the negative effects of environmental factors;
• Normalizes microcirculation in the skin;
• Moisturizes all layers of the skin;
• Eliminates pigment spots and whitens the skin;
• Smoothes wrinkles;
• Provides lifting;
• Narrows pores;
• Helps eliminate acne and fade its marks.

Due to these effects on the skin, Aevit is used in the following cases:

• Problem skin (acne, pimples, comedones, etc.);
• Excessive sebum production;
• Aging dry skin;
• Dermatitis or psoriasis.

For these conditions, Aevit can be used both topically (externally) and internally. At the beginning of treatment, cosmetologists recommend taking Aevit orally in the standard course - 1 capsule once a day for 20 - 30 days. After completing this course of treatment, you can switch to using Aevit externally. If the skin was not very problematic at the time of starting therapy, then it is recommended to immediately use Aevit only externally.

The use of Aevit externally is safe, since in this case only allergic reactions are possible as side effects. Before use, it is recommended to conduct a skin allergy test to avoid having to stop allergic rashes. The test is carried out as follows: the oil from the capsule is applied to the inner surface of the forearm and left for a day. If after 24 hours no signs of allergy appear on the skin of the forearm, then Aevit can be safely used externally, that is, applied to any area of ​​the skin.

Aevit can be applied externally to the skin of the face in various ways, for example, in pure form, mixed with cream or as part of a mask. Let's consider the rules of all three methods of external use of Aevit for the face.

Use of Aevita in its pure form. You need to take a capsule, pierce it with a clean needle, squeeze out the oil and gently apply it to cleansed facial skin, including the area around the eyes. Leave the oil on the skin overnight and wash with warm water in the morning. Thus, Aevit should be applied to the skin of the face daily until improvements appear (the minimum course of application is 10 days), but not longer than 40 days. After just a 15-day course of using Aevita, wrinkles will smooth out and become less noticeable, acne will almost completely disappear, and the overall condition of the skin will significantly improve. When the course of therapy with Aevit is completed, in the future the oil can be applied to the skin once a week to maintain the achieved result.

Application of Aevit as part of a cream. Pierce the Aevita capsule and add 2 – 3 drops of oil to the cream, which will be applied to the face at a time. After thoroughly mixing the composition, apply it to a cleansed face and leave overnight. Similarly, Aevit can be used for as long as desired, since the drug in the cream acts as a prophylactic and not a therapeutic agent.

This means that if it is necessary to cure acne or eliminate other problems on the skin of the face, Aevit should be used in its pure form. And to maintain good skin condition and slow down the aging process, it is optimal to use Aevit as part of a cream.

Application of Aevit with a mask. Masks with Aevit are most effective for smoothing wrinkles and slowing down skin aging, so they are recommended for mature women. To obtain the desired effect, you should add 3-4 drops of Aevita oil from the capsule to any anti-aging mask, mix well and apply the composition to the face. After 20 - 30 minutes, wash off the mask with warm water. Such masks are made 1 – 2 times a week for a long time.

Aevit for hair

The drug Aevit enhances growth, stops hair loss and strengthens hair roots, and also gives it shine and elasticity. Aevit is especially good for treating thin and split ends.

Aevit for hair can be taken orally or applied externally (as on the skin). The drug is taken orally according to the standard regimen - 1 capsule once a day for 20 - 30 days. Aevit is used externally in its pure form or to enrich masks, shampoos and other hair care products.

In its pure form, the oil from the Aevita capsule is poured onto the hair roots and rubbed in thoroughly, massaging the scalp. Leave the oil overnight and wash your hair with shampoo in the morning. This Aevit hair mask can be done every day for a week or 2 times a week for 1.5 months.

To enrich masks, shampoos and other hair care products, Aevit is used as follows: pierce the capsule with a needle and add 3-4 drops of oil to the amount of cosmetic product that will be used at a time. You can constantly add Aevit to various hair care products.

Aevit around the eyes

To reduce existing wrinkles around the eyes and prevent the appearance of new ones, Aevit is recommended to be used in its pure form. That is, you need to pierce the capsule with a needle, apply a small amount of oil to the skin around the eyes and leave it overnight. In the morning, wash with warm water. It is recommended to apply similar Aevita applications to the skin around the eyes 1 – 3 times a week.

Aevit for acne

The drug can be used both for the systemic treatment of a large number of pimples and blackheads on the face, and for the targeted elimination of single inflammatory elements present on the skin. To treat a large number of pimples and blackheads, Aevit must be taken orally or applied pure to the entire face. And to treat isolated rashes, Aevit is applied to them pointwise.

It is necessary to take Aevit orally only if there are acne on the face. In such a situation, the drug is taken 1 capsule 1 time per day for a month. Every six months, the course of treatment with Aevit can be repeated in order to maintain the achieved results and prevent relapse.

If there are only pimples on the face, then Aevit is enough to be used externally, that is, simply applied to the skin. To get the maximum effect, apply Aevit to the skin following the following rules:

• Cleanse the skin with a scrub or exfoliant;
• Puncture the Aevita capsule, squeeze out the oil from it and apply a thin layer to the skin of the face;
• Leave the oil overnight and wash with warm water in the morning.

Thus, Aevit is applied to the skin once a day for 15 days in a row. After this, they must take a break for 3–6 months, after which the course of therapy is repeated, if necessary.

If there are single pimples or inflammatory elements on the face or body, the oil from the Aevita capsule should be applied pointwise only to them and left for several hours. When the oil is smeared or absorbed into the skin, it is reapplied. In this way, acne is treated until it completely disappears (usually, after treatment with Aevit, acne completely disappears within 1 - 2 days).

Aevit for wrinkles

Aevit for wrinkles is used externally, both in its pure form and as part of creams or masks. In its pure form, the oil from the Aevita capsule is applied to the face, including the area around the eyes, and left overnight, washed in the morning with warm water. To smooth out existing wrinkles and prevent the appearance of new ones, such Aevita applications are done 1 – 2 times a week for a long time. Typically, for a pronounced effect it is necessary to make 8 - 10 applications.

In addition, oil from Aevita capsules can be added to any anti-aging masks in the amount of 3 - 4 drops per amount of product that will be used at a time. Such compositions enriched with Aevit can be used daily for a long period of time.

Side effects

Aevit in the form of capsules and intramuscular injections can provoke the following side effects from various organs and systems:

• Drowsiness;
• Lethargy;
• Headache;
• Allergic reactions;
• Short-term increase in body temperature (hyperthermia);
• Rashes on the skin;
• Feeling of discomfort in the stomach area;
• Nausea;
• Vomit;
• Diarrhea;
• Gait disturbance;
• Pain in the bones, especially in the lower extremities;
• Increased cerebrospinal fluid pressure (in children);
• Overdose of vitamins A or E;
• Exacerbation of cholelithiasis (attack of cholelithiasis);
• Exacerbation of pancreatitis.

When administering Aevita solution intramuscularly, in addition to the above-mentioned side effects, local reactions may appear, such as pain and hardness in the injection area. If the seal does not resolve for a long time, it may become calcified.

Contraindications for use

Aevit capsules and injections strictly contraindicated for use in the following cases:

• Age under 14 years (in some CIS countries – under 18 years);
• The presence of individual hypersensitivity or an allergic reaction to any components of the drug;
• Hypervitaminosis A and E (acute or chronic overdose of vitamins A and E).

In addition to these absolute contraindications for Aevita capsules and intramuscular injections, there are also relative ones. Relative contraindications mean conditions in which it is not advisable to use Aevit, but if necessary, this can be done with caution and under the supervision of a doctor.

So, to relative contraindications The use of Aevit includes the following conditions and diseases:

• Decompensated heart failure;
• Cardiosclerosis;
• Myocardial infarction;
• High risk of thromboembolism;
• Increased permeability of blood vessels;
• Acute or chronic glomerulonephritis or nephritis;
• Cholecystitis;
• Cholelithiasis;
• Cirrhosis of the liver;
• Viral hepatitis;
• Chronic pancreatitis;
• First trimester of pregnancy (up to the 13th week inclusive);
• Breastfeeding period;
• Kidney failure;
• Hypoprothrombinemia (low prothrombin content in the blood);
• Previous history of sarcoidosis.

In some countries of the former USSR, national Ministries of Health classify some or all relative contraindications for use as absolute, thereby narrowing the scope of practical use of the drug. The most severe restrictions on the use of Aevit are in Kazakhstan, where almost all relative contraindications are classified as absolute. You should be aware of this nuance and not be alarmed when you see different lists of contraindications for use in the instructions approved by the Ministries of Health of different countries.

In the list of absolute contraindications, we included only those conditions for which Aevit really cannot be used under any circumstances. And relative contraindications include all the others, which in the instructions of some countries may be included in both the lists of absolute and relative contraindications.

Aevita's analogs

On the domestic pharmaceutical market there are two drugs analogous to Aevit in terms of active ingredients - Vitaminel and Aevit Mite. These analogue drugs, like Aevit, contain high dosages of vitamins A and E as active components.

Composition and release form of the drug

◊ Capsules soft gelatinous, spherical in shape, from yellow to light brown, filled with an oily liquid from light yellow to dark yellow, without a rancid odor.

* 1 g of retinol substance (vitamin A palmitate, substance stabilized by BHA/BHT - oil solution) contains: - 1.7 million IU, butylated hydroxyanisole (BHA) - 9 mg, butylated hydroxytoluene (BHT) - 9 mg.

PRING] sunflower oil - up to 200 mg.

Shell composition (in terms of absolute dry matter): gelatin - 52.75 mg, glycerol - 16.8 mg, methyl parahydroxybenzoate - 0.45 mg.

10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (4) - cardboard packs.
20 pcs. - polyethylene cans (1) - cardboard packs.
30 pcs. - polyethylene cans (1) - cardboard packs.
40 pcs. - polyethylene cans (1) - cardboard packs.
10 pieces. - contour cell packaging (50) - cardboard boxes (for hospitals).
10 pieces. - contour cell packaging (100) - cardboard boxes (for hospitals).
10 pieces. - contour cell packaging (200) - cardboard boxes (for hospitals).
20 pcs. - polyethylene cans (42) - cardboard boxes (for hospitals).
20 pcs. - polyethylene cans (54) - cardboard boxes (for hospitals).
30 pcs. - polyethylene cans (42) - cardboard boxes (for hospitals).
30 pcs. - polyethylene cans (54) - cardboard boxes (for hospitals).
40 pcs. - polyethylene cans (42) - cardboard boxes (for hospitals).
40 pcs. - polyethylene cans (54) - cardboard boxes (for hospitals).

pharmachologic effect

A combined drug whose effect is determined by the properties of its constituent fat-soluble A and E.

Retinol (vitamin A): is a necessary component for the normal function of the retina of the eye: by binding to opsin (the red pigment of the retina), it forms visual purple rhodopsin, which is necessary for visual adaptation in the dark. Vitamin A is necessary for bone growth, normal reproductive function, embryonic development, for the regulation of division and differentiation of the epithelium (increases the reproduction of epithelial skin cells, rejuvenates the cell population, inhibits keratinization processes). Vitamin A takes part as a cofactor in various biochemical processes.

Function of α-tocopherol (vitamin E): as an antioxidant, it inhibits the development of free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes, which is important for the development of the body, the normal function of the nervous and muscular systems. Together with selenium, it inhibits the oxidation of unsaturated fatty acids (a component of the microsomal electron transfer system) and prevents hemolysis of red blood cells. It is a cofactor of some enzyme systems. Restores capillary blood circulation, normalizes capillary and tissue permeability, increases tissue resistance to hypoxia.

Pharmacokinetics

Tocopherol: When taken orally, approximately 50% of the dose taken is slowly absorbed, C max after 4 hours. Absorption requires the presence of bile acids. Deposited in the adrenal glands, pituitary gland, testes, adipose and muscle tissue, red blood cells, and liver. It is metabolized and excreted from the body (unchanged and in the form of metabolites) with bile (over 90%) and urine (about 6%).

Retinol: When taken orally, retinol is absorbed almost completely; even with excessive administration, no more than 10% of the administered amount is excreted in the feces. During metabolism, retinyl palmitate, retinol, retinal and retinoic acid are formed. It is distributed unevenly in the body: the largest amount is in the liver and retina, the smaller amount is in the kidneys, heart, fat depots, lungs, lactating mammary gland, adrenal glands and other endocrine glands. Retinol, retinal, retinoic acid are secreted by hepatocytes in the bile, retinoyl glucuronide is excreted in the urine.

Elimination of fat-soluble vitamins (tocopherol and retinol) occurs slowly, so repeated doses lead to accumulation.

Indications

Hypo- and avitaminosis A and E, as well as conditions of increased body need for vitamins A and E and/or decreased intake of them into the body: gastrectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome, chronic cholestasis, cirrhosis of the liver, biliary atresia pathways, obstructive jaundice, cystic fibrosis of the pancreas, tropical sprue, infectious diseases (including chronic and colds), hemeralopia, xerophthalmia, keratomalacia, poor and unbalanced nutrition (including parenteral nutrition), rapid weight loss , nicotine addiction, drug addiction, a state of prolonged stress, taking cholestyramine, colestipol, mineral oils, iron-containing products, when prescribing a diet with a high content of polyunsaturated fatty acids, hyperthyroidism.
Peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia.

Contraindications

Hypersensitivity, hypervitaminosis A and E, children (up to 18 years), pregnancy, lactation.

Carefully

Thyrotoxicosis, cholecystitis, conditions accompanied by increased vascular permeability (CHF, chronic glomerulonephritis, etc.), liver cirrhosis, viral hepatitis, renal failure, alcoholism, old age, hypoprothrombinemia (due to vitamin K deficiency - may increase with a dose of vitamin E more than 400 ME).

Dosage

Inside. The dosage regimen is individual, depending on the indications, the patient’s age and the clinical situation.

Side effects

Systemic reactions: allergic reactions.

From the digestive system: pain in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea); with long-term use in large doses, exacerbation of cholelithiasis and chronic pancreatitis is possible.

Local reactions(with intramuscular injection) - pain, infiltration, soft tissue calcification.

Drug interactions

Retinol weakens the effect calcium preparations, increases the risk of developing hypercalcemia.

Cholestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamins A and E (their dose may need to be increased).

Oral contraceptives increase the concentration of retinol in.

Isotretinoin increases the risk of developing retinol toxicity.

Simultaneous use tetracycline and retinol in high doses (50 thousand units and above) increase the risk of developing intracranial hypertension.

Tocopherol (vitamin E) enhances the effect GCS, NSAIDs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides. Taking vitamin E in high doses may cause vitamin A deficiency in the body.

Tocopherol (vitamin E) increases efficiency antiepileptic drugs in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood).

Simultaneous use of vitamin E at a dose of more than 400 IU/day

Instructions for use:

Pharmacological actions of Aevit

Aevit is a vitamin complex preparation with immunostimulating and antioxidant properties. The Aevit complex, reviews of which are definitely positive from doctors and patients, consists of two vitamins - A (retinol palmiate) and E (alpha-tocopherol acetate). Aevit vitamins promote tissue regeneration, participate in lipid and protein metabolism, have a positive effect on vision, support the reproductive function of the body, improve blood circulation, restore vascular permeability and tissue trophism.

All the effects described above from the use of Aevit are possible due to the pharmacological properties of vitamins A and E.

Vitamin A is responsible for tissue metabolism, can increase cellular and humoral immunity, enhances myelopoiesis, and improves the function of macrophages. By taking vitamin A, you can reduce the risk of diseases of the mucous membranes of the respiratory tract and digestive tract. Thanks to the participation of this vitamin in the Aevit complex, its use slows down keratinization and rejuvenates cells. The beneficial effect of the drug Aevit on reproductive function is also due to the participation of vitamin A in this complex. In addition, retinol palmiate is involved in the formation of the visual signal, bone tissue, promotes bone growth, and has a positive effect on the functioning of the sweat, sebaceous, and lacrimal glands.

Also, vitamin A, thanks to the unsaturated bonds of the retinol molecule, interacts with different types of radicals and stimulates the antioxidant function of vitamin E, which, in turn, being the second important component of Aevit, prevents the oxidation of retinol, thereby preventing the formation of toxic products.

In addition, vitamin alpha-tocopherol acetate (E) is responsible for regulating metabolic processes in the human body, protecting cells from the action of free radicals, preventing hemolysis of red blood cells, and has a positive effect on microcirculation and tissue trophism, and the vascular system.

Alpha tocopherol also stimulates immunity, both general and humoral, and cellular. Thanks to this component of the Aevit complex, the activity of T-lymphocytes increases. In addition, in combination with vitamin A, normal formation of the reproductive system and embryonic development is ensured.

The pharmacokinetic properties of Aevit are determined by the pharmacokinetics of its components.

Absorption of Aevit: Vitamin E is absorbed in the digestive tract, and vitamin retinol is absorbed in the gastrointestinal tract. The components of Aevita, vitamins A, E, are distributed evenly in tissues and organs, while excess vitamin A is deposited in the liver, and vitamin E is deposited in muscle, adipose tissue, adrenal glands, testes, liver, and red blood cells.

Metabolism of Aevit: Vitamin A is metabolized in the liver into active and inactive metabolites. Vitamin E forms only pharmacologically inactive metabolites during metabolism.

Removal of Aevit: retinol acetate is excreted as metabolites in urine and bile. This happens slowly: after a one-time use, a third of the vitamin taken is removed from the human body for another three weeks. Vitamin E is excreted only in bile, and in urine only in small quantities.

Indications for use of Aevita

Due to its complex composition, Aevit is prescribed for a number of diseases. Therapy using Aevit is prescribed to patients who, for various reasons, require long-term intake of large amounts of vitamins E and A.

According to Aevit’s instructions, this is necessary and justifies itself in a number of cases:

Impaired microcirculation and tissue trophism;

Vascular atherosclerosis;

Endarteritis obliterans;

Psoriasis, lupus erythematosus;

Optic nerve atrophy, night blindness (hemeralopia), keratomalacia, xerophthalmia, retinitis pigmentosa;

The use of Aevit is also indicated for those patients who have limited nutrition and a reduced intake of vitamins A and E in a natural way, for the following diseases and conditions:

• diarrhea;
• gastrectomy;
• steatorrhea;
• Crohn's disease, malabsorption, celiac disease;
• cholestasis in the chronic stage, obstructive jaundice, obstructed bile ducts, cirrhosis of the liver;
• pancreatic disease - cystic fibrosis;
• infectious diseases in acute and chronic conditions;
• poor nutrition, rapid weight loss (Aevit vitamins are often prescribed to those on parenteral nutrition to compensate for the lack of retinol and alpha-tocopherol acetate)
• alcohol, nicotine, drug addiction;
• prolonged stress;
• use of medications, mineral oils that contain iron (for example, neomycin, cholestyramine, colestipol)
• a diet that causes an increased intake of polyunsaturated fatty acids;
• hyperthyroidism
• peripheral neuropathy;
• abetalipoproteinemia;
• necrotizing myopathy.

How to use Aevit

Aevit vitamins are taken after meals, swallowed whole (not chewed) and washed down with water.

The average course of treatment, according to Aevita’s instructions: for an adult – 30 – 40 days. one capsule once every 24 hours. But more individual dosages of Aevita and the duration of the course are prescribed by the doctor who is seeing the patient. According to observations and reviews, Aevit, if used incorrectly, can lead to undesirable consequences.

For a more precise prescription and the possibility of repeating the use of Aevit (only 3 months or six months after the end of the last course - according to the instructions of Aevit), it is necessary to know exactly the nature of the disease and the characteristics of the patient’s body.

Description of side effects of Aevit

According to the description and reviews, Aevit is well tolerated, but there are statistics of side effects associated with the use of Aevit:

1) vomiting, nausea, allergic manifestations, gastralgia, stool disorders - isolated cases associated only with the individual characteristics of the patient’s body;

2) exacerbation of chronic pancreatitis, cholelithiasis - in those who took Aevit for a long time;

3) hypervitaminosis A. It is expressed in damage to the peripheral and central nervous system - sleep disturbances, irritability, headache, paresthesia, apathy. Damage to the skin may also appear - cracks and dryness of the feet and palms, seborrhea, alopecia. According to reviews, Aevit also led to pain in the joints, enlargement of the spleen, liver, and changes in gait, but all this was observed during long-term use of the drug and in dosages that exceeded the recommended ones.

Contraindications to the use of Aevit

1. Individual intolerance to the vitamins included in Aevita;

2. Thyrotoxicosis, chronic glomerulonephritis, and chronic circulatory failure;

3. Myocardial infarction, risk of thromboembolism, severe atherosclerosis of the coronary arteries, acute and chronic inflammation of the kidneys (Aevit is prescribed, but with great caution);

According to the instructions, taking Aevita during pregnancy and lactation is allowed only with the permission of a doctor.

Capsule pharmaceutical drug contains: retinol palmitate () – 100,000 IU; alpha-tocopherol acetate () – 0.1 g; sunflower oil as an excipient. The gelatin shell contains the following components: gelatin; glycerol; methyl parahydroxybenzoate (E 218); propyl parahydroxybenzoate (E 216).

Compound vitamins in the form of an injection solution(1 ml): acetate retinol – 0.035 g; alpha tocopherol acetate – 0.1 g.

Compound Aevit cream: vitamin A ; vitamin E ; and ethylhexyglycerin; blend of extracts (raspberry, rosemary, edelweiss); propylheptyl caprylate; propylglyceryl-3 methylglucose distearate; caprylic/capric/triglycerides; erucate oleyl; higher fatty alcohols; glyceryl stearate; glycerol; demineralized water.

Release form

Aevit vitamins are supplied to pharmacy kiosks in three main pharmaceutical forms:

• Soft gelatin capsules spherical or spherical in shape, yellow or light brown in color with a clearly defined dividing line. The shell is filled with an oily medicinal liquid, the color of which can vary from light yellow to dark yellow, which does not indicate the unsuitability of the drug. Capsules are packaged in glass jars of 25 pieces each or in blister packs of 10 pieces.
• Liquid injection solution in ampoules for 1 ml of vitamin product. A cardboard box contains 10 pieces and an annotation.
• Nourishing cream Aevit for the face in bottles of 50 ml. 1 bottle and instructions in each carton.

pharmachologic effect

Aevit is a combination drug whose active components take part in a large number of different metabolic processes and physiological reactions in the body. The therapeutic capabilities of a pharmaceutical drug are striking in their breadth, because vitamin complex simultaneously possesses and , And immunomodulatory properties, has a stimulating effect on the reproduction of epithelial cells and tissue growth, and accordingly promotes reparative And regenerative capabilities of individual organs and systems.

The drug improves blood supply to the microcirculatory bed, normalizes the permeability of the vascular wall throughout the entire circulatory system, and increases the quality of trophic processes. Biologically active components are necessary for the normal functioning of the visual and reproductive systems, the correct course of protein and lipid metabolism. The mechanism of action of the drug should be considered separately for each vitamin.

Retinol palmitate (or acetate in some variations of Aevita), better known as - This fat-soluble chemical compound . It is generally accepted that most of the effects of this component are concentrated on the organs of vision, but this is only half of the true biochemical picture of the interactions of vitamin A. Of course, the biological component takes an invaluable part in the formation of the visual signal, as it promotes the transformation of the protein structure of opsin into rhodopsin. This protein conversion is especially important for the eyes in low light conditions.

Another significant group of therapeutic effects of vitamin A lies in its influence on immune system . First of all, it should be noted the general strengthening effect, then, upon closer examination, the following are striking:

• gain myelopoiesis ;
• activation macrophage system ;
• increase in humoral and factor;
• strengthening the protective mechanisms of the mucous membrane of the gastrointestinal system and respiratory tract.

The regulatory abilities of vitamin A extend not only to the main types of metabolism (protein, fat, etc.), but also to the functioning of the external and internal secretion glands, including the lacrimal, sebaceous and sweat glands. In combination with other effects, this makes it possible to use Aevit for hair as a cosmetic and therapeutic product, to prevent possible destruction of hair shafts and follicles, and to provide the structural units of the hair with all the necessary trophic substances.

From the point of view of organic chemistry, retinol is a molecule with a large number of unsaturated bonds, which allows vitamin A to participate in various redox reactions . The therapeutic effects of this feature of the biologically active substance are especially noticeable when applied externally to the skin:

• retains the required amount of intracellular fluid;
• plays an important role in education glycosaminoglycans ;
• stimulates reproduction epithelial cells , which allows you to rejuvenate the skin and get rid of wrinkles;
• provides antioxidant effect ;
• improves capillary blood circulation and local protective mechanisms, which is why Aevit for acne is popular among the young category of patients.

Alpha tocopherol or , the second active component of the pharmaceutical drug Aevit, is a fat-soluble chemical compound that is part of the natural human body and, like vitamin A, has many beneficial therapeutic effects with additional exogenous intake.

First of all, Wikipedia, the free encyclopedia of world knowledge on the Internet, celebrates him antioxidant activity . That is, the constituent component of the drug slows down the oxidation of unsaturated fatty acids and, thus, reduces the formation of peroxide compounds, which prevents and destruction of other cellular structures. Also, the mechanism of antioxidant activity of vitamin E includes its ability embed into membranes , preventing contact with oxygen and free radicals circulating in the blood. This property of alpha-tocopherol determines the use of Aevit for the skin around the eyes; the problem area of ​​the face retains youth and elasticity much longer if vitamin E is used regularly.

The active ingredient of a pharmaceutical preparation has extensive effects on cardiovascular system . Alpha tocopherol is a cofactor of various enzymatic systems of the body, which is realized in such positive therapeutic effects as stimulation of microcirculation, normalization of trophic processes in tissues, improving capillary blood flow and permeability of a given segment of the vascular bed. This determines the use of Aevit as a health measure for eyelashes and nails, because the derivatives of the skin primarily suffer from various kinds of pathological conditions due to the peridistributive capacity of the vascular system.

Vitamin E has an effect on protective function body. In particular, it stimulates the cellular and humoral components of the immune system, and the activity of T-lymphocytes increases significantly. By inhibiting lysosomal phospholipase A2, the potential for destruction of the phospholipid layer of cell membranes is eliminated.

Strengthening protective functions is an incredibly important task for everyone, because it is much easier to prevent a disease than to subsequently sanitize a pathological focus, for which Aevit tablets are best suited due to the content of vitamins A and E.

Pharmacodynamics and pharmacokinetics

The pharmacokinetic capabilities of the combined drug practically do not depend on the chosen form of release after entering the systemic circulation, so it is enough to consider only one example. The capsules are well absorbed from the digestive tract, after which they are transported into the lymph and blood plasma, where they bind to specific carrier proteins and “travel” to organs and tissues. A quantitative excess of vitamin A is stored in the liver in the form of palmitic acid esters, where the main stages of its biotransformation take place before the elimination stage. Elimination is slow—only 34% of the dose taken is removed within 3 weeks.

Excess of another active ingredient, vitamin E, deposited everywhere in body tissues. Metabolic processes occur by converting the natural structure of the drug component into quinine, after which it is eliminated along with urine. In unchanged form, vitamin E can be eliminated in bile.

Indications for use of Aevita

• vascular bed;
• obliterative And endarteritis ;
• regional or systemic disturbances of microcirculation and tissue trophism ;
• peripheral neuropathy;
• atrophy optic nerve;
• xerophthalmia ;
• necrotizing myopathy ;
• keratomalacia ;
• abetalipoproteinemia ;
• pigmentary retinitis .

Indications for use also include pathological conditions when the intake of vitamins A and E from food is significantly reduced, which allows Aevit to be used in the treatment of the following nosological units:

• gastrectomy ;
• chronic;
• steatorrhea ;
• diseases of the small intestine of various origins ( celiac disease , Crohn's disease , malabsorption syndrome and so on);
• cystic fibrosis pancreas;
• and pathologies that impede the physiological flow of bile into the lumen of the digestive tube;
• acute and chronic infectious diseases ;
• idiopathic weight loss ;
• unbalanced or inadequate nutrition;
• chronic stress ;
• addiction, And nicotine addiction .

Contraindications

• increased sensitivity to the active components of the vitamin complex;
• thyrotoxicosis ;
• chronic ;
• chronic circulatory failure .

Contraindications for Aevit vitamins do not include a number of nosological entities for which the use of a pharmaceutical drug is recommended only under the supervision of qualified medical personnel. The list of such diseases is as follows:

• or the risk of its development;
• severe forms coronary arteries;
• acute and chronic inflammatory diseases of the kidneys of a nonspecific nature.

Side effects

The use of Aevit vitamins, as a rule, is well tolerated by patients, because the active components of the pharmaceutical drug are part of the physiological metabolism of the human body and are required for normal development. In isolated cases, side effects may occur in the form of one of the following adverse effects:

• nausea and the next one after it vomit ;
• stool disorders;
• gastralgia;
• increased irritability;
• exacerbation cholelithiasis And chronic in the presence of a latent phase of the course of pathologies.

Vitamins Aevit, instructions for use (Method and dosage)

Instructions for use of Aevita in capsules

How to take Aevit in capsules - orally, swallowing the entire tablet. It is not recommended to chew it or keep it in the mouth for a long time, since the gelatin shell, in this case, may be damaged, which will inevitably lead to a decrease in the therapeutic activity of the drug. The standard dosage for realizing the full biochemical potential of the active ingredients is 1 capsule once a day, and the duration of treatment is 30-40 days.

To prevent various diseases from the list above, the course of conservative sanitation is 20-30 days, but a preventive treatment regimen with the full use of a pharmaceutical drug for 30-40 days can also be used. Repeated therapy, as in the case of combating a clearly defined pathology, is recommended to be carried out no earlier than 3-6 months from the end of the previous course.

How to take vitamins for mastopathy?

Vitamins A and E in large quantities, as, for example, in Aevit, have a positive effect on the hormonal background of the female body and the condition of the mammary glands in particular, which makes the prescription of a pharmaceutical drug mammologists rational and pathogenetic, that is, affecting certain links in the development of nosological units in various types of diseases of the mammary glands.

The dosage of the drug is 1 capsule per day for a month. Such courses of conservative therapy are carried out twice a year, but some experts believe that capsules can be taken continuously, since cannot be natural vitamins. This theory is currently not completely reliable and is not supported by all medical professionals.

Method of using Aevit vitamins in the form of a solution

This form of the drug is used for intramuscular injections , that is, the solution can be injected into the buttocks, the anterior and lateral surface of the abdomen, shoulders and trapezius muscle, the anterior surface of the thigh. Before direct use of the pharmaceutical drug, the required amount should be slightly warmed up in order to activate it. The standard dosage is 1 ml once a day, and the duration of the course of conservative treatment is 20 days. In case of trophic disorders, endocarditis and endarteritis, it is increased to 30-40 days. Repeated sanitation can be carried out after 4-6 months.

The pharmaceutical drug is not used for children for reasons stated below in the relevant section.

How to use Aevit externally?

To improve the general condition of the skin, get rid of wrinkles, and are most suitable for cosmetic and therapeutic effects on the lips pharmaceutical wraps . Before manipulation, you should thoroughly cleanse the skin and massage. Thus, the selected area will be well prepared for the application of the drug, which will somewhat increase the therapeutic capabilities of the active components of Aevita.

Next, mix the contents of the ampoule with an oily solvent. Ideally suited for this purpose olive oil , because in itself it has a beneficial effect on the skin. Apply the resulting mixture to the selected area and rub in a little. After this, cover the treated area of ​​skin with a plastic bag (or cling film), wrap it in a towel and wrap it in warm blankets. There is no need to wash off anything after applying the medicine; the oil allows Aevit to be well absorbed.

The duration of such manipulation is half an hour, and it can be carried out twice a week for two months, after which the necessary therapeutic effect will be noted, and the skin will become smooth, fresh and soft.

How to use the cream?

A small amount of ointment should be applied to previously cleansed skin in the direction of natural massage lines. Due to the peculiarities of the composition of this pharmaceutical form, Aevit can be used both in the morning and in the evening, a couple of hours before bedtime. The course of therapeutic measures lasts for 1-2 months with daily use of the cream, then you should take a break.

Hair vitamins - how to use at home?

Aevit for hair is used according to the most complex of the proposed schemes, as it combines external treatment of the scalp with pre-prepared mixtures and the use of drug capsules orally. It is in this combination that the most accelerated and complete effect is achieved.

To eliminate the problem dry and brittle hair the contents of 1-2 Aevit capsules should be mixed with 2 raw egg yolks or 1 tablespoon of low-fat sour cream. Next, using massaging movements, you need to rub the resulting mixture into the scalp. The exposure of the applied drug is 1.5-2 hours, after which the mask can be washed off with regular everyday shampoo. The frequency of this procedure is 1-2 times a week for three months. To repeat a conservative course, you should wait at least six months.

So that accelerate hair growth, A slightly modified recipe is used, for which a liquid injection solution is also suitable. The juice of one medium-sized onion is added to the contents of 1-2 capsules or 1 ampoule and mixed thoroughly until the future mask is homogeneous. The mixture is applied with massaging movements to clean hair, after which it is recommended to wrap your head in a towel or put on a plastic cap and leave it for half an hour. At the end of the procedure, you need to wash your hair with your usual shampoo. The mask shows effectiveness if used twice a week for a month, after which there is a long break, and the procedure is repeated only when strictly necessary.

Overdose

Aevit tablets or injection solution may cause vitamin A hypervitaminosis , which manifests itself as chronic intoxication with this biologically active substance and is observed as the following symptoms:

• damage to the central and peripheral nervous system;
• disturbances in sleep and wakefulness;
• a sudden increase in cerebrospinal fluid pressure without changing its qualitative composition;
• heart failure;
• convulsions;
• increased irritability;
• dryness and cracks in the skin (especially in the area of ​​​​the feet and palms);
• joint pain;
• alopecia ;
• seborrhea ;
• increase in the size of the liver and spleen.

There is no specific pharmaceutical antidote for an overdose of Aevit; in case of development of symptoms of drug intoxication, treatment of the observed clinical manifestations and immediate contact with a qualified specialist is indicated to eliminate the pathological condition that threatens the patient’s life.

Terms of sale

You can buy a vitamin preparation without a prescription.

Storage conditions

The medicine should be stored in a dry place, away from possible direct sunlight, at a constant temperature of 15 to 25 degrees Celsius.

Best before date

Synonyms

VitAE , AEcaps .

For children

The pharmaceutical drug is not used in pediatric practice, since hypervitaminosis of one of the active components of Aevita can adversely affect the further development of the child and cause irreversible consequences in the growing young body.

Aevit during pregnancy and lactation

Face cream, tablet and injection forms of the pharmaceutical drug Aevit are contraindicated for use directly during and , since an excess of vitamins can adversely affect the developing body of a child, and it is impossible to precisely regulate the intake of a certain amount due to the complex pathways of transformation and metabolic chains of the active components of the drug.

The beneficial therapeutic effect of combined vitamins Aevit is known and clinically confirmed by experienced and qualified specialists in planning pregnancy . The drug is prescribed in advance, before the critical period, in order to deposit the necessary structural elements and not experience the need for them during pregnancy or lactation. According to antenatal clinics, such preventive measures help protect the expectant mother and child.

Most of us want to look young and attractive for as long as possible. This is especially important for women. The condition of our body is influenced by many factors - from bad habits to an unfavorable environment, and stress primarily affects the face, where the skin is most susceptible to physiological changes. That is why it is best to start taking care of the condition of your facial skin at a young age. At the same time, expensive and complex products are not required: Aevit, available to everyone, is an indispensable drug that contains vitamins that support the beauty and health of not only the skin, but also the entire body. The special advantages of Aevit are the price, which is affordable for everyone, and the unusually high efficiency in rejuvenating the body.

What vitamins does Aevit contain, why do the body need them and how do they work?

Composition of "Aevita"

What makes Aevit a special drug is its composition. There are two vitamins in it: A (retinol) and E (tocopherol). The drug is taken as prescribed by a doctor if there is a shortage of these substances in the body. When they are deficient, the skin becomes dry and gray in color. Vitamin A helps improve the condition of the skin from the inside, as it normalizes the functioning of the body as a whole, in particular the digestive system. Vitamin E promotes the absorption of other elements, including vitamin A.

These substances, of course, are also found in foods, but we do not always receive adequate nutrition, in which the body is replenished with a sufficient amount of necessary vitamins, minerals, etc. “Aevit” contains all of them in the required volume.

Effect of vitamins

Or vitamin A, an important component for the restoration of epithelial skin cells, which is where its rejuvenating effect lies.

Retinol is also required for the normal functioning of the retina and other processes associated with vision, bone growth and fetal development, and is involved in many biochemical processes in the body.

Hypovitaminosis leads to a number of skin abnormalities - dryness, peeling, dermatitis, diaper rash. also manifests itself in the so-called decrease in vision when moving from a light place to a dark place. In children, in addition, a long-term lack of retinol can lead to a decrease in immunity and, in some cases, to delayed mental and physical development.

Tocopherol, or vitamin E, is an antioxidant that prevents the formation of harmful substances in the body that can damage cells and tissues. Therefore, it is extremely important in the functioning of the nervous and muscular systems. It also prevents the accumulation of free radicals in the body, prevents oxygen starvation of tissues, and participates in the synthesis of growth hormones and gonadotropins. Together with selenium, it slows down the oxidation of unsaturated fatty acids and prevents the destruction of red blood cells.

Hypovitaminosis occurs infrequently and is most often associated with impaired absorption and lack of plant products in the body. With a lack of tocopherol, the condition of the skin worsens, immunity decreases, and the risk of anemia increases.

Rules for taking "Aevita"

As you can see, a lack of vitamins A and E seriously affects the entire body and negatively affects its condition. And internal problems always affect the appearance - the skin deteriorates, primarily on the face, nails become brittle, brittle, hair grows poorly, becomes weak, dull, and falls out. “Aevit” is designed to restore the balance of vitamins in the body, so it often becomes a real salvation for fading beauty and freshness, provided it is used in accordance with the instructions.

"Aevit" is taken both orally - in the form of capsules, and intramuscularly - in the form of injections. Capsules are taken one per day, regardless of food intake, injections - 1 ml per day. The course of treatment is from 20 to 40 days, then a break is required for 3-6 months, after which the course can be repeated. To avoid the development of hypervitaminosis, do not exceed the recommended dosage or continue the course of treatment longer than the specified period when taking Aevit vitamins.

Indications for use

First of all, the drug is prescribed to those who suffer from a lack of vitamins A and E in the body.

In some cases, the body needs increased consumption of retinol and tocopherol. Sometimes they enter the body in smaller quantities than necessary. This is compensated by taking the drug “Aevit”, for which they take up to 2 capsules orally 3 times a day:

• after removal of the stomach;
• with diarrhea;
• for liver disease;
• for eye diseases, including night blindness;
• when the lumen of blood vessels in the extremities narrows.

"Aevit" must be taken if you are an experienced smoker, if you have lost weight quickly (and this has led to disruption of some body functions), or with prolonged stress. In addition, during intake and products, the body requires the vitamins contained in the drug “Aevit”, for which they are taken together with iron supplements.

"Aevit" for skin beauty

The drug actively improves metabolism, as a result of which the vast majority of skin problems are eliminated: inflammation, ulcers and acne are significantly reduced, dryness and flaking disappear. But “Aevit” has a particularly beneficial effect on wrinkles: after several courses of treatment, they become less pronounced, the skin acquires elasticity, and the relief improves.

Vitamin “Aevit” for facial skin can be used both internally and externally - in the form of masks, lotion, or added to the cream you use. This is another option for taking Aevit vitamins in capsules. The instructions do not contain information about external use. But usually (as experts recommend) the contents of 1-2 capsules are enough to wipe your face or add to a cosmetic product. You can use the drug in this way for no longer than a month; then, as the skin gets used to it, the effectiveness will decrease.

"Aevit" for hair

If your hair is brittle, dull, oily, or falling out, then “Aevit” is an ambulance for your hair! It is also indispensable for some scalp diseases. The instructions say nothing about this positive property of the drug, but it has been proven (confirmed by practice) that regular use of Aevita not only maintains the health of the body, but also actively affects the condition of the hair.

It is necessary to take the drug in accordance with the instructions, in extreme cases - in agreement with the doctor - increase the dosage to 2 capsules 2-3 times a day. Tocopherol and retinol in combination help restore skin elasticity and tissue regeneration functions, the roots are strengthened, as a result, hair grows faster and becomes healthier.

"Aevit" can also be used as a mask - when applied, vitamins penetrate directly into the scalp, accelerating and enhancing the effect. To see immediate results - shiny and elastic curls, use the vitamins contained in the Aevit preparation, for which they are added to the shampoo before washing your hair. The disadvantage of this method is that the problem with split ends is not solved.

It is also useful to rub the contents of one or two capsules into the scalp at night and rinse in the morning with hair detergent. Within a month you will notice how much the condition of your hair has improved, how voluminous and voluminous your hair has become.

Contraindications

Since Aevit is a medicinal drug, you should consult a doctor before using it orally or intramuscularly. Like any medicine, Aevit has a number of contraindications that should never be ignored.

First of all, this is undoubtedly an existing hypervitaminosis. In addition, "Aevit" cannot be used for diseases such as thyrotoxicosis, glomerulonephritis, renal failure, some other kidney diseases, as well as cholecystitis, cholelithiasis, hypoprothrombinemia.

Alcoholism is a contraindication for taking the drug.

Contraindications also include:

• cardiovascular failure;
• cardiac ischemia;
• thrombophlebitis;
• pyelonephritis.

Those who have hypersensitivity or individual intolerance to the components should not take the drug. In this case, Aevit cannot be used externally either.

"Aevit" for pregnant women

According to the latest scientific data, Aevit, previously actively prescribed to expectant mothers, can be dangerous during pregnancy. Previously, it was believed that the drug improves the possibility of conception and prevents early miscarriages. But now it has become clear that the vitamin content in the drug is higher than the norm allowed during pregnancy. And if the permissible dose is exceeded, retinol can lead to pathologies of intrauterine development; tocopherol causes pregnancy complications and provokes late toxicosis.

For the same reason, it is unacceptable to take Aevit vitamins in childhood. However, for children, including for the normal development of the fetus, both vitamins contained in the preparation are required, because their deficiency also leads to problems in the development of the body. To get out of this vicious circle, it is recommended that during pregnancy and children they obtain them from food. Many foods are rich in retinol: greens, vegetables, such as carrots, fermented milk products, tocopherol is present in large quantities in vegetable oil, potatoes, cucumbers and a number of other products.

If Aevit was prescribed before pregnancy, then during pregnancy planning it is better to discontinue the drug, since retinol accumulates in the liver and is excreted from the body within several months, and this process is not accelerated in any way even by cleansing the liver.

If the onset of pregnancy coincides with taking this drug, it is necessary to neutralize its effect and reduce the risk of pathologies that Aevit entails, for which they take folic acid in an increased dose to the maximum (up to 5 mg per day). If there are no contraindications, you should also take Iodomarin. In addition, mandatory ultrasound examination and screening are recommended.

Side effects

Taking Aevita as a fairly strong and effective drug may be accompanied by side effects, such as allergic reactions, abdominal pain, nausea, vomiting, and diarrhea. With prolonged use of high doses, cholelithiasis or pancreatitis may develop.

Hypervitaminosis is another side effect of a drug such as Aevit. The composition of vitamins in it and the dose are selected in such a way as to interact most effectively with the body. An overdose of the drug will not give the best result, but it can harm your health, sometimes significantly.

With an excess of vitamin A, lethargy, drowsiness are possible, the patient may complain of headache, dizziness, nausea. Sometimes irritability and increased excitability are observed. Among the negative effects of an overdose of retinol are bleeding gums, dry mouth, peeling of the lips and palms. If vitamin intoxication occurs, then there are complaints of bone pain, vomiting, hyperthermia, increased intraocular pressure, hypertension, severe headache, epigastric pain and other symptoms.

Hypervitaminosis E is rare, most often its symptoms are minor, but if it is taken for a long time at a dose of over 400 units/day, then complaints of blurred vision, headaches and dizziness, nausea, diarrhea, pain in the stomach, over 800 may appear. units/day - thrombophlebitis, thromboembolism, sepsis and other serious pathologies are possible.

Treatment of side effects consists of discontinuation of the drug and symptomatic therapy.

Interaction with other drugs

"Aevit" is often taken together with other medications for various reasons. First of all, you need to inform your doctor about what medications you are already taking. Interaction with some reduces the effectiveness of Aevit or the drug taken with it or even leads to unpleasant consequences. But some, on the contrary, act more effectively under the influence of the vitamins contained in the drug "Aevit", for which they can be prescribed by a doctor together.

Various mineral oils, Colestipol, Kolestyramine reduce the absorption of retinol and tocopherol.

Oral contraceptives promote the accumulation of vitamins in plasma.

When taking Aevita and drugs of the tetracycline group together, the possibility of increasing intracranial pressure increases.

Tocopherol enhances the effect of antioxidants, vitamins A and D, cardiac glycosides, reduces their toxicity, but if the dosage is exceeded, it increases the risk of vitamin A deficiency.

High doses of iron supplements and iron-containing products enhance oxidation processes, as a result of which the body's need for vitamin E increases.

Summary

A real salvation for skin, hair, nails is the drug “Aevit”. Its price is low, on average about 40 rubles for a package of 10 capsules and just over a hundred rubles for a package of 30 capsules. It is sold at any pharmacy without a prescription.

"Aevit" has a rejuvenating effect on the body as a whole, and as a result of improving the internal state, positive external changes will not take long to appear.

However, "Aevit" is not a preventative, but a therapeutic agent, so self-medication can lead to dangerous consequences. To avoid hypervitaminosis, it should be used only after consultation with a doctor in a strictly prescribed dosage.

You can also try cosmetics to which Aevit has been added at the factory, such as creams, hygienic lipsticks, etc. And then the effect of using this drug will definitely please you!