In the process of in vitro fertilization, embryo transfer is the final stage, after which the doctor will necessarily prescribe medications to support the luteal phase. These drugs help improve implantation. This includes hCG and progesterone medications. When the transfer has taken place, the patient experiences a difficult and stressful period. It is still unknown whether pregnancy will occur or not. Therefore, many patients are interested in why pregnyl is prescribed after embryo transfer.

Embryo transfer

The onset of pregnancy is determined using a certain test after two weeks. According to the analysis, the hCG hormone is measured. It is synthesized only by the cells of the embryo. Consequently, these are very long days in the life of a woman who wants to get pregnant.

After the embryo implantation process, experts do not advise taking a hot shower or bath, not performing heavy physical activity, and also avoiding sexual intercourse for now. But the very next day the girl can go about her activities and return to her usual routine. But some women don't get out of bed for two weeks until they take the test. They get up to eat and go to the toilet.

Perhaps this is necessary so that, when pregnancy does not occur, you do not reproach yourself for anything and be calm that everything has been done. But it is worth remembering that standard activity does not affect the likelihood of pregnancy. After embryo transfer, the doctor prescribes hormonal medications.

Naturally, the menstrual cycle becomes longer. The drug is excreted from the body individually for each patient. This process is influenced by metabolic processes and weight. This usually happens around five days.

Pregnil after embryo transfer affects the increased work of the corpus luteum.

Doctors say that with the help of rot, the own functions of the ovaries are activated and maintained. The dosage is prescribed to each patient individually. The doctor sets the dose based on how active the ovaries are, what the hormone levels are and how the stimulation was performed.

Application

In the treatment process, the timing of hCG administration is considered a serious point, accordingly, the medicine must be administered at the exact time that is calculated. Hands should be washed and dried thoroughly. Initially, prepare a syringe, cotton balls with alcohol and the drug.

The ampoule with the dry composition is pulled out of the box, and the plastic coatings that protect it are removed. Each ampoule is treated separately with a cotton pad soaked in alcohol.

Insert the needle from the syringe into the very center of the rubber cap of the jar where the solvent is located. Turn the ampoule over. Draw 3 ml of solvent into the syringe. Then remove the air from the syringe and perform an intramuscular injection. After embryo transfer, Pregnil or Horagon injections are prescribed.

Why is Pregnil injected after embryo transfer:

• 3⁄4 Induce ovulation;
• 3⁄4 The egg matures in the artificial insemination program;
• 3⁄4 After ovulation has occurred, the corpus luteum appears. The drug helps the ovaries secrete progesterone.

Experts say that taking care of your baby increases the chance of a successful pregnancy.

Horagon and rotted

How long does it take for ovulation to occur after taking pregnil? This drug not only initiates ovulation, but also controls it. Therefore, ovulation should occur no earlier than 35 hours. If this happens earlier, then such cases are an exception. So about half of the artificial insemination processes would not produce results. Thus, pregnyl is applied 35 hours before the puncture. Some women claim that the hCG level decreases after pregnyl 1500, and the test begins to give positive results.

How much does pregnil 1500 cost? This is individual, perhaps some patients drink a large amount of liquid. But basically this process lasts about twelve days.

In a situation where the follicle has grown but does not rupture, choragon is used. The active substance is human hCG, according to which the onset of pregnancy is determined.

How to breed choragon? Can be diluted with one ampoule. Pour the solvent into the dry substance, dilute it, and put it into a syringe. Haragon 1500 after embryo transfer is prescribed to deceive the body. It seems to the body that it has become pregnant, so it works for the embryo. HCG is produced in the blood when a woman is pregnant.

Thus, many are interested in what is better: rotten or choragon? According to opinions, the drugs do not differ much from each other. Some clinics prescribe only pregnyl, while others only prescribe choragon. If you pay attention to the reviews, patients don’t really see any difference. What is better ovitrel or pregnil? Medicines are prescribed individually. The difference is that ovitrel is injected into the stomach. Each patient tolerates the drug differently.

"Pregnil" is used in the treatment of anovulatory infertility in women, miscarriage, the threat of self-abortion, as well as for the purpose of controlled hyperstimulation of the ovaries, induction of ovulation and increasing estrogen levels. Its use is effective in a regimen of endogenous luteal hormone replacement therapy to stimulate follicle maturation.

Indications for use in men include hypofunction of the gonads, cryptorchidism, and impaired spermatogenesis. Let's look at the most famous analogue of "Pregnil" in this article.

Description of the drug "Pregnil"

Increased irritability, emotional lability, headaches, anxiety.

Dyspeptic disorders (nausea, vomiting).

Increased sensitivity of the nipples.

Gynecomastia in men.

Temporary enlargement of the penis, pathological erection.

Decreased functioning of the pituitary gland.

Decrease in circulating blood volume (hypovolemia).

Accumulation of blood in the abdominal cavity.

Thromboembolism.

Multiple pregnancy.

Fluid retention, severe, widespread edema.

The Pregnil 1500 analogue is ineffective for congenital defects of the uterus, appendages and vagina, adhesions in the fallopian tubes, primary ovarian failure, large fibrous tumors in the uterus.

All therapy is carried out strictly under the supervision of a specialist and monitoring of changes in tests; the use of these drugs at home is unacceptable and can lead to irreparable health consequences.

Treatment of anovulatory infertility should be carried out under ultrasound monitoring of follicular growth and constant assessment of the cervical index.

Daily monitoring of estradiol concentration levels is important. If symptoms of unwanted ovarian hyperstimulation occur, human chorionic gonadotropin therapy should be discontinued immediately.

We have reviewed analogues for the drug "Pregnil", instructions for use for them are also described.

According to the classification of drugs, Pregnil is a gonadotropic drug based on human chorionic gonadotropin. It has the ability to normalize hormonal balance and improve the function of the reproductive organs. The product is produced by the Dutch pharmacological company Organon. Read the instructions for the medicine.

Composition and release form

Pregnyl is available in powder form for preparing a solution. Its composition:

Pharmacodynamics and pharmacokinetics

The medicine replaces the release of endogenous luteinizing hormone in the female body. The drug is prescribed when planning pregnancy, it serves as an auxiliary method before artificial insemination, supports the luteal phase of the cycle, and improves ovarian function. In men, Pregnil activates the process of testosterone synthesis. Once inside, the active component reaches its maximum concentration within 20 hours in women and 10 hours in men. 80% of ingested gonadotropin is metabolized by the kidneys.

Why is Pregnil prescribed?

According to the instructions for use, Pregnil has different indications for men and women. These are the following states:

1. For men: hypogonadism, cryptorchidism, delayed puberty due to failure of the gonadotropic function of the pituitary gland, disruption of spermatogenesis.
2. For women: stabilization of the corpus luteum, induction of ovulation and superovulation in case of problems with conceiving a child.

Directions for use and dosage

Instructions for use of Pregnil indicate that the drug is administered by injection. To do this, the solvent is mixed with the lyophilisate, and the resulting solution is slowly injected subcutaneously or intramuscularly. For hypogonadism, dyspermia and delayed puberty in men and boys, 1000-2000 IU is prescribed 2-3 times a week. Children under 6 years old with cryptocorchism are given 500-1000 IU 2-3 times a week, over 6 years old - 1500 IU with the same frequency. Therapy for men lasts about 6 weeks and is repeated if necessary.

In women, after treatment with Humegon Pregnil, it is administered once at a dosage of 5000-10000 IU. To support the corpus luteum phase, patients are given injections of 5000-10000 IU 1-3 times. The medicine should be used for nine days after ovulation or follicular puncture. Pregnyl is used with caution in prepubescent boys because there is a risk of early closure of the pineal gland or puberty. When treating children, it is necessary to monitor the growth and development of the skeleton.

Drug interactions

The instructions for use do not indicate drug interactions between Pregnil and other drugs. According to patient reviews, it is not recommended to take a pregnancy test before 10 days have passed since the last infusion. Doctors do not recommend carrying out such a test until 14 days after ovulation or embryo transfer - there is a high risk of getting false positive or false negative results. For a reliable analysis, you need to check the level of hCG (human chorionic gonadotropin) over time - using a blood test.

Side effects of Pregnil

Side effects often occur during Prgenil therapy. Possible negative reactions, according to the instructions, are:

• fever;
• generalized rash;
• bruising at the injection site, swelling, itching, redness, pain;
• thromboembolism;
• hydrothorax (accumulation of water in the lungs);
• abdominal pain;
• nausea, diarrhea;
• ascites;
• ovarian hyperstimulation;
• increase in cysts on the ovaries;
• weight gain;
• in boys and men: gynecomastia, sodium and water retention in the body.

Overdose

If the frequency of administration of Pregnil is exceeded or its overdose during infusion, increased side effects may occur. With prolonged administration of doses exceeding those indicated in the instructions, ovarian hyperstimulation syndrome may develop. This is dangerous, so you need to consult a doctor for help and special symptomatic therapy.

Contraindications

The medicine is prescribed with caution if there is a risk of developing thrombosis, latent or diagnosed heart failure, arterial hypertension, renal dysfunction, migraine, epilepsy. Instructions for use highlight contraindications:

• tumors caused by sex hormones;
• formation of genital organs with abnormalities in women;
• pregnancy;
• fibrous tumor of the uterus.

Terms of sale and storage

Pregnyl is a prescription drug that should be kept away from children and sunlight. It is stored at a temperature of 2-15 degrees for no longer than three years.

Analogs

The drug can be replaced with products based on the same active ingredient and with the same properties. Analogues of Pregnil:

• Chorionic gonadotropin is a lyophilisate for the preparation of an infusion solution with the active ingredient of the same name.
• Profasi – ampoules with powder for infusion based on hCG;
• Choragon – powder for solution based on human chorionic gonadotropin;
• Ecostimulin is a lyophilisate for injection with the same active ingredient as its analogue.

, sodium dihydrogen phosphate .

Release form

Pregnyl is sold in ampoules with lyophilized powder For infusions . They are contained in blister packaging. The kit includes solvent in ampoules. There are three sets in one box.

pharmachologic effect

Gonadotropic means.

Pharmacodynamics and pharmacokinetics

For women, the medicine is used as a substitute release of endogenous luteinizing in the middle of the cycle. This remedy is prescribed during planning as an auxiliary method before artificial insemination in order to support luteal phase of the menstrual cycle or to improve ovarian function. For men, it is used to enhance the educational process.

The maximum concentration of the active component is achieved after administration of the drug within 20 hours in women and 6-16 hours in men. About 80% human chorionic gonadotropin is metabolized in the kidneys.

Indications for use

This product has its own indications for men and women:

• for women - ovulation induction And superovulation , maintaining function corpus luteum ;
• for men - hypogonadism , delayed puberty in case of insufficiency gonadotropic functions, disorders spermatogenesis , .

Contraindications

The drug should not be used if:

• hypersensitivity to its components;
• related to sex hormones.

In addition, the drug is not used in boys in case of premature puberty, and in women - if the genital organs are formed with deviations that are incompatible with pregnancy, as well as in cases of incompatibility with pregnancy. fibrous tumor of the uterus .

The medicine should be taken with caution if women are at risk of developing, and men have latent or obvious heart failure , arterial hypertension , problems with kidney function, . When using Pregnil, boys should also be under the supervision of a specialist. prepubescent age, to avoid early closing epiphyses or puberty. It is necessary to monitor the development and growth of the skeleton.

Side effects

The following side effects may occur in patients of both sexes when using this medication:

• generalized rash ;
• reactions at the injection site: bruising, redness, pain, swelling.

Women who are prescribed Pregnil may experience:

• thromboembolism ;
• hydrothorax ;
• painful sensations in the abdomen;
• nausea;
• ascites ;
• unwanted ovarian hyperstimulation ;
• ;
• soreness of the mammary glands;
• enlarged ovaries and ovarian cysts;
• large;
• weight gain.

Side effects observed in men and boys include:

• water and sodium retention;
• gynecomastia .

Instructions for use of Pregnil (Method and dosage)

The instructions for Pregnil 5000 and other forms of release of the drug indicate that the medicine is used in the form of injections. She also tells how to inject this drug into patients: the solvent is mixed with lyophilisate , and the solution is slowly introduced subcutaneously or intramuscularly .

Dosages are individual in each case:

• at hypogonadism , delayed puberty and dyspermia prescribe 1000–2000 IU 2–3 times a week;
• at cryptorchidism children under 6 years of age are given 500–1000 IU 2–3 times a week, and older children are given injections of Pregnil 1500 2–3 times a week. Therapy is designed for 6 weeks. If necessary, it can be repeated;
• with the aim of ovulation induction after therapy Humegon 5000–10000 IU of medication is used once;
• in order to maintain the phase corpus luteum Prescribe 5000–10000 IU for injection 1–3 times. The medicine is administered within 9 days after ovulation or follicle punctures .

Overdose

It is expected that increased doses of the drug may cause ovarian hyperstimulation syndrome .

Interaction

The drug interaction of this drug with other drugs has not been studied.

On forums, in addition, people are often interested in such a combination as Pregnil 1500 and. Experts recommend performing a pregnancy test no earlier than 10 days after the last infusion of this drug. Some doctors say that after ovulation or refills embryo and at least 2 weeks must pass before the test can be carried out. So women should not draw premature conclusions: the results may be false positive , And false negative .

On various forums, women often discuss the effectiveness of medications that are most often used in the case of in vitro fertilization. For a long time, doctors have developed special protocols that describe all the procedures and drug use regimens necessary for this. Until the finished embryo is transferred, the woman must take a large number of medications. Since a very important result is at stake, patients simply storm the Internet with questions about what is best to choose. Among such discussions one can also find discussions on the topic: Ovitrel or Pregnil. Let's try to review the main characteristics and find the differences in these drugs.

Pregnil is obtained from the urine of pregnant women. Ovitrel is a gonadotropin that is produced using recombinant DNA technology. It follows from this that Pregnil has a more natural origin.

Dosage

Ovitrel in a dose of 250 IU is identical in activity to 5000 IU or 10,000 IU of gonadotropin, which is obtained from urine.

Side effect

Negative reactions after using Ovitrel or Pregnil are the same and manifest themselves in nausea, vomiting, abdominal pain, but the most serious side effect is ovarian hyperstimulation syndrome.

Overdose

Human chorionic gonadotropin has low toxicity, therefore Pregnil and Ovitrel, with the correct dose selection, do not provoke the appearance of overdose symptoms.

Price

Pregnil 3 syringes in a dose of 1500ME can be purchased for 1250-1330 rubles. Ovitrel 1 syringe in a dose of 250Me can be bought for 2100-2200 rubles.

Most often, it is the cost that encourages women to purchase Pregnil. Also, patients who have experience using these medications describe that Ovitrel (unlike Pregnil) does not cause such a strong reaction in the body.

All women should understand that each person has a different body and, accordingly, the reaction may simply not be predictable. Before deciding to use analogues, it is important to consult with your doctor. You should not rely on brief reviews on the Internet and reviews. The main adviser should only be an experienced specialist.